A5101912210- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- interferon and immune responses
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Glioma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Fluorine in Organic Chemistry
- RNA regulation and disease
- Ferroptosis and cancer prognosis
- Vibrio bacteria research studies
- S100 Proteins and Annexins
- Cancer Mechanisms and Therapy
- NF-κB Signaling Pathways
- Trace Elements in Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- Zebrafish Biomedical Research Applications
- Enzyme function and inhibition
Feed Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Shengli Oilfield Central Hospital
2023
Tianjin Medical University General Hospital
2010-2022
Tianjin Medical University
2010-2022
Brigham and Women's Hospital
2016-2022
Zaozhuang Municipal Hospital
2021
Jinan Central Hospital
2021
China Medical University
2020
First Affiliated Hospital of Zhengzhou University
2019-2020
Inflammasome activation plays key roles in host defense, but also contributes to the pathogenesis of auto-inflammatory, and neurodegenerative diseases. As autophagy is connected with both innate adaptive immune systems, autophagic dysfunction closely related inflammation, infection, neurodegeneration. Here we identify that lincRNA-Cox2, previously known as a mediator repression genes expression cells, could bind NF-κB p65 promote its nuclear translocation transcription, modulating...
Objective: Long non-coding RNAs (lncRNAs) are critical to colorectal cancer (CRC) progression. In the current study, objective was exploration of role played by lncRNA MIR4435-2HG in CRC proliferation and metastasis. Methods: expression its association with were analyzed using database clinical specimens. The influences exerted on cell proliferating process, invading migrating process identified after knockdown. tumor growth metastasis assessed vivo. underlying mechanistic associations...
// Limo Chen 1,* , Bertal H Aktas 1,2,* Yibo Wang 1 Xiaoying He 1,3 Rupam Sahoo Nancy Zhang Severine Denoyelle Eihab Kabha Hongwei Yang Revital Yefidoff Freedman Jeffrey G Supko Michael Chorev 1,2 Gerhard Wagner and Jose A Halperin Harvard Medical School 2 Brigham Women's Hospital 3 Massachusetts General * These authors are equal contributors Correspondence: A. email: Keywords : Translation, eIF4F, eIF4E, ternary complex, eIF2 Received August 09, 2012, Accepted 24, Published 25, 2012...
Breast cancer is the leading cause of oncological mortality among women. Efficient detection cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) critical regulators fundamental cellular processes a variety including breast cancer. The functional details these regulatory elements, however, remain largely unexplored.In this study, lncRNA ROR (linc-ROR) was...
Quercetin is a widely-occurring flavonoid that protects against cancer, and improves memory cardiovascular functions. However, whether quercetin exhibits therapeutic effects in diabetic retinopathy remains unclear. In this study, we established rat model of streptozocin-induced retinopathy. Seventy-two hours later, the rats were intraperitoneally administered 150 mg/kg for 16 successive weeks. markedly increased thickness retinal cell layer, number ganglion cells, decreased overexpression...
Temozolomide (TMZ) is a standard chemotherapeutic drug used in the treatment of glioblastoma multiforme (GBM); however, resistance to this common. SRY-Box 9 (SOX9) expression associated with poor prognosis patients GBM and TMZ. Therefore, aim study was examine effects SOX9 inhibition on sensitivity glioma cells TMZ treatment. We knocked down (SOX9KD) via lentiviral infection two (U87 U251) cell lines, were then subjected gene microarray, Gene Ontology KEGG analysis pathway, all which...
Background: Inflammation and angiogenesis are the two dominant mechanisms of diabetic retinopathy (DR), which act more as mutual pathways rather than individual processes. However, underlying mechanism their interactions is still unclear. Here, we explored potential crossing points between these targeted therapeutic method in rats with DR. Materials Methods: Sprague–Dawley were randomly assigned to four groups: normal control group, streptozocin (STZ)-induced diabetes mellitus (DM) DM+shNC...
Human diploid cell strains (HDCSs), possessing identical chromosome sets known to be free of all adventitious agents, are great use in developing human vaccines. However it is extremely difficult obtain qualified HDCSs that can satisfy the requirements for mass production We have developed a new HDCS, Walvax-2, which we derived from lung tissue 3-month-old fetus. established primary, master and working banks successfully reconstituted frozen cells. Observations during concurrent propagation...
The present study aimed to investigate the location, expression and clinical significance of Iroquois homeobox gene (IRX1) in human glioma. IRX1 glioma cell lines (U87, U373, LN229 T98G) normal brain tissue was detected via reverse transcription-polymerase chain reaction. protein fresh specimens, with adjacent tissue, quantified through western blotting. archived only specimens from hospital Alenabio biotechnology, were subjected immunohistochemistry microarray analysis, respectively....
Glioma is the most frequent malignant neoplasm of central nervous system with high recurrence and extremely poor prognosis. Hexokinase 2 (HK2) key enzyme in Warburg effect that has been proved to promote tumorigenesis found highly expressed several tumors. However, HK2 function glioma was reported only a few studies. In this review, we will summarize changes energy metabolism critical process. Further, recent research progress perspective diagnosis treatment be discussed.
Vaccines are one of the most practical means to stop spreading
Objective To explore the effects of miR-218 on biological functions renal cell carcinoma line through regulating expression levels miR-218.Methods The pcDNA3.1-miR-218 was transfected into A498 and 769-P detected.The activity,invasion,apoptosis proliferation were analyzed in vitro.Results After plasmid A498/769-P line,the level (1.99,1.64) significantly higher than that control group (1.00) (t =60.82,10.89,P ＜ 0.000 1) viability (0.90±0.10,0.68±0.06) lower (1.39±0.14,1.24±0.08) by CCK8...
：Objective To explore therelationship between the tumor necrosis factor-α(TNF-α) T1031C and C863A gene polymorphisms senile ischemic stroke(IS) in elderly patients.Methods One hundred fifty patients with IS 110 age andgender-matched controls were recruited this study. The genepolymorphisms detected by using polymerase chain reaction-restriction fragment lengthpolymorphism (PCR-RFLP) assay these subjects. Data coded analyzed SPSSWindows (version 11.5): differences of genotype allele...