A5101778654- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Cellular Mechanics and Interactions
- Bone and Joint Diseases
- Bone health and treatments
- Orthopaedic implants and arthroplasty
- Medical Imaging Techniques and Applications
- 3D Printing in Biomedical Research
- Bone fractures and treatments
- Elasticity and Material Modeling
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Parathyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Erythrocyte Function and Pathophysiology
- Ion channel regulation and function
- Hip disorders and treatments
- Spaceflight effects on biology
- Autophagy in Disease and Therapy
- Spine and Intervertebral Disc Pathology
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Radiomics and Machine Learning in Medical Imaging
Tongji Hospital
2023-2025
Huazhong University of Science and Technology
2023-2025
Sun Yat-sen University
2021-2025
Columbia University
2015-2024
Hebei University of Technology
2024
Hebei North University
2022
Tianjin Medical University
2017-2021
Maine Medical Center Research Institute
2021
Tufts University
2021
University of Maine
2021
The ability to engineer anatomically correct pieces of viable and functional human bone would have tremendous potential for reconstructions after congenital defects, cancer resections, trauma. We report that clinically sized, shaped, grafts can be engineered by using mesenchymal stem cells (hMSCs) a “biomimetic” scaffold-bioreactor system. selected the temporomandibular joint (TMJ) condylar as our tissue model, because its clinical importance challenges associated with complex shape....
A screen of microRNAs preferentially expressed in osteoblasts identified members the miR-34 family as regulators osteoblast proliferation and/or differentiation. Osteoblast-specific gain- and loss-of-function experiments performed vivo revealed that miR-34b -c affected skeletogenesis during embryonic development, well bone mass accrual after birth, through two complementary cellular molecular mechanisms. First, they inhibited by suppressing Cyclin D1, CDK4, CDK6 accumulation. Second,...
Inflammasome activation plays key roles in host defense, but also contributes to the pathogenesis of auto-inflammatory, and neurodegenerative diseases. As autophagy is connected with both innate adaptive immune systems, autophagic dysfunction closely related inflammation, infection, neurodegeneration. Here we identify that lincRNA-Cox2, previously known as a mediator repression genes expression cells, could bind NF-κB p65 promote its nuclear translocation transcription, modulating...
Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development disease-modifying therapy. The functional relationship between subchondral bone (SB) and articular cartilage (AC) is unclear. Here, we found that changes SB architecture altered distribution mechanical stress on AC. Importantly, latter well aligned with pattern transforming growth factor beta (TGFβ) activity in AC, which essential regulation AC homeostasis. Specifically, TGFβ...
High-resolution peripheral quantitative computed tomography (HR-pQCT) is a newly developed in vivo clinical imaging modality. It can assess the 3D microstructure of cortical and trabecular bone at distal radius tibia suitable as an input for microstructural finite element (microFE) analysis to evaluate bone's mechanical competence. In order image-based microFE analyses become standard tools, validation with current gold standard, namely, high-resolution micro-computed (microCT), required....
Abstract Trabecular plates and rods are important microarchitectural features in determining mechanical properties of trabecular bone. A complete volumetric decomposition individual was used to assess the orientation morphology 71 human bone samples. The ITS-based morphological analyses better characterize microarchitecture help predict anisotropic Introduction: Standard architecture lack explicit segmentations rods. In this study, a technique developed segment microstructure into...
Measuring the microscopic mechanical properties of bone tissue is important in support understanding etiology and pathogenesis many diseases. Knowledge about these provides a context for estimating local environment related cells that coordinate adaptation to loads experienced at whole organ level. The objective this study was determine effects experimental testing parameters on nanoindentation measures lamellar-level properties. Specifically, we examined effect specimen preparation...
In the milder form of primary hyperparathyroidism (PHPT), cancellous bone, represented by areal bone mineral density at lumbar spine dual-energy x-ray absorptiometry (DXA), is preserved. This finding in contrast to high-resolution peripheral quantitative computed tomography (HRpQCT) results abnormal trabecular microstructure and epidemiological evidence for increased overall fracture risk PHPT. Because DXA does not directly measure HRpQCT widely available, we used score (TBS), a novel...
Abstract High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new in vivo imaging technique for assessing 3D microstructure of cortical and trabecular bone at the distal radius tibia. No studies have investigated extent to which measurements skeleton by HR-pQCT reflect those spine hip, where most serious fractures occur. To address this research question, we performed dual-energy X-ray absorptiometry (DXA), central QCT (cQCT), HR-pQCT, image-based finite-element...
The sympathetic nervous system, whose activity is regulated by leptin signaling in the brain, a major regulator of bone mass accrual. To determine identity cell type which tone signals to inhibit accrual, we performed systematic, cell-specific analysis function β2 adrenergic receptor (Adrβ2) and various genes implicated pathway mouse. This was followed intracerebroventricular (ICV) infusion histomorphometric analyses parameters. We show that osteoblasts CREB (cAMP-responsive element-binding...
Measurement of areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) has been shown to predict fracture risk. High-resolution peripheral quantitative computed tomography (HR-pQCT) yields additional information about volumetric BMD (vBMD), microarchitecture, and strength that may increase understanding susceptibility. Women with (n = 68) without 101) a history postmenopausal fragility had aBMD measured DXA trabecular cortical vBMD microarchitecture the radius tibia...
Abstract The vast osteocytic network is believed to orchestrate bone metabolic activity in response mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin (OPG). However, the mechanisms osteocyte mechanotransduction remain poorly understood. We’ve previously shown that mechanosensitivity encoded unique intracellular calcium (Ca 2+ ) dynamics. Here, by simultaneously monitoring Ca actin dynamics single cells exposed fluid shear flow, we detected contractions...
There is a critical need to increase the size of bone grafts that can be cultured in vitro for use regenerative medicine. Perfusion bioreactors have been used improve nutrient and gas transfer capabilities reduce limitations inherent static culture, as well modulate cellular responses by hydrodynamic shear. Our aim was understand effects medium flow velocity on phenotype formation bone-like tissues three-dimensional engineered constructs. We utilized custom-designed perfusion culture...
Bariatric surgery results in bone loss at weight-bearing sites, the mechanism of which is unknown.Twenty-two women (mean body mass index 44 kg/m(2); aged 45 years) who underwent Roux-en-Y gastric bypass (n = 14) and restrictive procedures 8) had measurements areal mineral density by dual-energy x-ray absorptiometry lumbar spine, total hip (TH), femoral neck (FN), one third radius trabecular cortical volumetric microstructure distal tibia high-resolution peripheral quantitative computed...
Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process maintains cell balance response to stress-related stimulation. Abnormal autophagy occurs many pathologies, such as cancer, and autoimmune neurodegenerative diseases. Hence, clarification of mechanisms regulation utmost importance. Recently, researchers presented microRNAs...