A5100387642- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Advanced biosensing and bioanalysis techniques
- PI3K/AKT/mTOR signaling in cancer
- Cancer Cells and Metastasis
- Digestive system and related health
- Ginseng Biological Effects and Applications
- Cutaneous Melanoma Detection and Management
- Medical Research and Treatments
- Signaling Pathways in Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Medicinal Plants and Bioactive Compounds
- Epigenetics and DNA Methylation
- Pericarditis and Cardiac Tamponade
- Pharmacological Effects of Natural Compounds
- Cardiac Structural Anomalies and Repair
- Thyroid Disorders and Treatments
- Plant-based Medicinal Research
Fujian Medical University
2020-2025
Shanghai Children's Medical Center
2025
Tianjin Medical University
2023
Tianjin Medical University Eye Hospital
2023
Shanghai Sixth People's Hospital
2023
Shanghai Jiao Tong University
2023
Binzhou Medical University
2023
Tianjin Medical University General Hospital
2023
Shandong Provincial Hospital
2018-2021
Minzu University of China
2021
ABSTRACT Thyroid peroxidase ( TPO ) gene mutations have been reported as the most commonly pathogenic variants in congenital hypothyroidism (CH) caused by thyroid hormone (TH) synthesis disorders, significance of some remains unclear. The study analyzed 54 children diagnosed with CH who underwent whole‐exome sequencing (WES). Functional analysis p.K78Q variant, a novel variant uncertain (VUS), revealed that it developmental defects zebrafish and also disrupted axis expression, decreasing tg...
Esophageal carcinoma (ESCA) is a common malignant gastrointestinal tumor. The abnormal expression of NOLC1 involved in the tumorigenesis various human tumors, whereas function and mechanism ESCA remain unclear. In this study, we explored relationship between poor prognosis ESCA, its role occurrence ESCA.The tissues cell lines was determined by qRT-PCR, immunohistochemistry, or western blot. Kaplan-Meier method conducted to estimate overall survival. Cox regression analysis carried out...
The molecular mechanisms driving tumorigenesis have continually been the focus of researchers. Cuproplasia is defined as copper-dependent cell growth and proliferation, including its primary secondary roles in tumor formation proliferation through signaling pathways. In this study, we analyzed differences expression cuproplasia-associated genes (CAGs) pan-cancerous tissues investigated their role immune-regulation prognostication.Raw data from 11,057 cancer samples were acquired multiple...
This study aimed to determine the expression levels of runt-related transcription factor 3 (RUNX3) and caudal-related homeobox 2 (CDX2) in patients with chronic gastritis, intestinal metaplasia, atypical hyperplasia, gastric cancer (GC). To analyze overexpression CDX2 effects resveratrol (Res) on MKN7 TMK1 cells, immunohistochemical staining was performed protein tissue samples. The biological activity cells determined. Relative mRNA were also RUNX3 positively correlated negatively β-catenin...
Dry eye disease (DED) is often secondary to diabetes mellitus (DM).
Background: Postsurgical recurrence within 2 years is the major cause of poor survival hepatocellular carcinoma (HCC) patients. However, molecular mechanism underlying HCC remains unclear. Here, we distinguish function and Sec62 in promoting recurrence.Methods: The correlation between early was demonstrated 60 samples from a prospective study. cells with knockdown (Sec62KD) or overexpression (Sec62OE) were used to determine potential cell migration vitro. Microarray analysis comparing...
Rationale: Owing to the unique structure and function of heart, tumor metastasis in heart is rare. Accordingly, no symptoms have yet been identified for cardiac metastasis. Patient concerns: A patient presented with 3 years after surgical resection alveolar soft tissue sarcomas their late stage. Diagnosis: Ultrasonography showed a middle-high echo clump on left surface mid-upper interventricular septum, which had an unclear boundary myocardium. Meanwhile, blood flow was found clump, blockage...
目的 探讨Notch和PI3K/Akt两条信号通路对人食管腺癌细胞OE33增殖、侵袭及迁移能力的影响及两条信号通路之间的联系.方法 应用Notch信号通路阻滞剂DAPT和PI3K/Akt信号通路阻滞剂LY294002分别单独和联合处理OE33细胞,设置对照组;Western blot和实时定量PCR法检测OE33细胞中NICD、Hes1、p-Akt、PTEN蛋白和mRNA的表达变化;CCK-8法检测细胞的增殖抑制率;划痕实验用于检测细胞迁移能力的变化;Transwell细胞侵袭实验用于检测细胞的侵袭能力变化.结果...
<div>Abstract<p><b>Purpose:</b> Lung cancer stem cells (CSC) with elevated aldehyde dehydrogenase (ALDH) activity are self-renewing, clonogenic, and tumorigenic. The purpose of our study is to elucidate the mechanisms by which lung CSCs regulated.</p><p><b>Experimental Design:</b> A genome-wide gene expression analysis was performed identify genes differentially expressed in ALDH<sup>+</sup> versus...
<div>Abstract<p><b>Purpose:</b> Lung cancer stem cells (CSC) with elevated aldehyde dehydrogenase (ALDH) activity are self-renewing, clonogenic, and tumorigenic. The purpose of our study is to elucidate the mechanisms by which lung CSCs regulated.</p><p><b>Experimental Design:</b> A genome-wide gene expression analysis was performed identify genes differentially expressed in ALDH<sup>+</sup> versus...
Topic: 11. Bone marrow failure syndromes incl. PNH - Biology & Translational Research Background: On the basis of our previous studies, we found that SUZ12 participate in proliferation clone by regulating H3K27me3. And then used immunoprecipitation and mass spectrometry to identify MIB2 interacting with SUZ12. Aims: We explore mechanism clones. hope improve pathogenesis a new target. Methods: have constructed PIGA gene knock-out K562 cell line(K562-KO) CRISPR/cas9. Immunoprecipitation were...
<div>Abstract<p>Protein S-palmitoylation is a widespread and dynamic posttranslational modification that regulates protein–membrane interactions, protein–protein protein stability. A large family of palmitoyl acyl transferases, termed the DHHC due to presence common catalytic motif, catalyzes S-palmitoylation; role these enzymes in cancer largely unexplored. In this study, an RNAi-based screen targeting all 23 members was conducted examine effects on growth non–small cell lung...
<div>Abstract<p>Protein S-palmitoylation is a widespread and dynamic posttranslational modification that regulates protein–membrane interactions, protein–protein protein stability. A large family of palmitoyl acyl transferases, termed the DHHC due to presence common catalytic motif, catalyzes S-palmitoylation; role these enzymes in cancer largely unexplored. In this study, an RNAi-based screen targeting all 23 members was conducted examine effects on growth non–small cell lung...
To carry out genetic testing for a male infant suspected Menkes disease.Genomic DNA of the proband and his parents were extracted subjected to family trio whole exome sequencing (WES). Microduplication microdeletion ATP7A gene detected by multiplex ligation-dependent probe amplification (MLPA). Suspected variants bioinformatic analysis verified Sanger sequencing.The was found harbor de novo c.1870 -13T>G variation gene, which may alter splice site affect its protein product.The patient...