A5039470649- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Heat shock proteins research
- Cervical Cancer and HPV Research
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- Cancer Treatment and Pharmacology
- Intraperitoneal and Appendiceal Malignancies
- MicroRNA in disease regulation
- Toxin Mechanisms and Immunotoxins
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Pediatric health and respiratory diseases
- Enzyme Structure and Function
- Advanced Breast Cancer Therapies
- Endometriosis Research and Treatment
- Medical Imaging Techniques and Applications
- Chemical Reactions and Isotopes
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
Memorial Sloan Kettering Cancer Center
2012-2024
Shanghai First People's Hospital
2015-2023
Shanghai Jiao Tong University
2015-2023
Cornell University
2012
Bristol-Myers Squibb (United States)
2011
Johns Hopkins University
2008
HSP90 is a chaperone protein required for the stability of variety client proteins. 17-Demethoxygeldanamycin (17-AAG) natural product that binds to and inhibits its activity, thereby inducing degradation these clients. In preclinical studies, HER2 one most sensitive known proteins 17-AAG. On basis data activity in phase I study, we conducted II study 17-AAG (tanespimycin) with trastuzumab advanced trastuzumab-refractory HER2-positive breast cancer.We enrolled patients metastatic HER2(+)...
This phase I study examined whether a heat shock protein (Hsp) 90 inhibitor tanespimycin (17-AAG; KOS-953) could be administered safely in combination with trastuzumab at dose that inhibits Hsp90 function vivo lymphocytes.Patients an advanced solid tumor progressing during standard therapy were eligible. Patients treated weekly followed by intravenous tanespimycin, assessed escalating levels.Twenty-five patients enrolled onto four levels: 225 (n = 4), 300 3), 375 8), and 450 mg/m2 10)....
Abstract Purpose: Microsatellite instability–high (MSI-H) endometrial carcinomas are underpinned by distinct mechanisms of DNA mismatch repair deficiency (MMR-D). We sought to characterize the clinical and genetic features MSI-H cancers harboring germline or somatic mutations in MMR genes MLH1 promoter hypermethylation (MLH1ph). Experimental Design: Of > 1,100 patients with cancer that underwent tumor-normal sequencing, 184 had due MLH1ph, harbored pathogenic mutations....
We conducted a phase I dose-escalation study to define the maximum tolerated dose (MTD), pharmacokinetics (PK), and pharmacodynamics of alvespimycin (17-DMAG), heat shock protein 90 (Hsp90) inhibitor, given in combination with trastuzumab.Patients were treated trastuzumab followed by intravenous on weekly schedule. Hsp90 client proteins measured at baseline serially peripheral blood lymphocytes (PBL) during cycle 1. Patients advanced solid tumors progressing standard therapy...
The purpose of our study is to present the radiographic findings in a series 16 patients with complications associated intravesical bacille Calmette-Guérin (BCG) treatment bladder cancer.Intravesical BCG-related such as granulomatous disease may show imaging mimicking primary or metastatic tumors cancer. Radiologists should consider this possibility when abnormalities are encountered cancer treated BCG so that appropriate management can be administered and unnecessary procedures avoided.
Imaging reports that consistently document all disease sites with a potential to increase surgical complexity or morbidity can facilitate ovarian cancer treatment planning.
Epichaperome network maintenance is vital to survival of tumors that express it. PU-H71 an epichaperome inhibitor binds the ATP-binding site HSP90 and has demonstrated antitumor activity in breast cancer xenograft models clinical safety patients. PU-positron emission tomography (PET) a theragnostic imaging tool allows visualization target. In this phase Ib trial, we present tolerability for plus nab-paclitaxel HER2-negative patients with metastatic (MBC) utility PU-PET as noninvasive...
Background: Several new blood vessels are formed during the process of tumor development. These provide nutrients and water for tumour growth, while spreading cells to distant areas forming metastases in different parts body. The available evidence suggests that angiogenesis is closely associated with microenvironment regulated by a variety pro-angiogenic factors and/or angiogenic inhibitors. Methods: In present study, comprehensive characterization genes expression was performed pan-cancer...
1042 Background: In a preclinical HER2+ BC model, combination anti-HER2 and anti-VEGF therapy was more effective than either treatment alone, increased VEGF expression is associated with worse outcome in disease. B plus trastuzumab (T) has shown promising activity patients (pts) MBC, however the cardiac toxicity of this regimen requires further evaluation. L, an oral dual inhibitor EGFR HER2, approved capecitabine after T-based for MBC. L may have less be safer alternative to T+B. This...
Abstract #3133 Background:
 HER2 overexpression has been shown to upregulate VEGF expression in pre-clinical breast cancer models. Overexpression of both and associated with worse clinical outcome than either receptor alone. In models, combination anti-HER2 anti-VEGF therapy be more effective treatment B plus trastuzumab (T) promising activity patients (pts) HER2+ MBC, however the cardiac toxicity this regimen requires further study. L, an oral dual tyrosine kinase inhibitor EGFR...
The purposes of this study were to determine the cause avascular hypoechoic lesions detected at scrotal ultrasound and assess usefulness sonographic clinical features in differentiating benign from malignant etiologic factors.This retrospective included 58 patients with testicular ultrasound. recorded lesion size margins presence peripheral vascularity focal calcifications. Also patient age, symptoms, risk factors, palpability, levels serum tumor markers. reference standard was pathologic...
The molecular mechanisms driving tumorigenesis have continually been the focus of researchers. Cuproplasia is defined as copper-dependent cell growth and proliferation, including its primary secondary roles in tumor formation proliferation through signaling pathways. In this study, we analyzed differences expression cuproplasia-associated genes (CAGs) pan-cancerous tissues investigated their role immune-regulation prognostication.Raw data from 11,057 cancer samples were acquired multiple...
501 Background: KOS-953 (17-AAG in Cremophor) is a potent Hsp90 inhibitor that vivo induces rapid degradation of Her2, loss pAKT and tumor growth inhibition Her2+ breast cancer xenograft. Objectives: Define the phase 2 dose + T. toxicity PK KOS-953, its active metabolite Assess changes intracellular signaling proteins (such as Hsp70) leucocytes. Describe antitumor activity. Methods: Eligible pts with advanced solid tumors (Her2 was not required) received standard weekly doses T followed by...
<h3>Background</h3> Gemcitabine is active in several gynecologic malignancies including ovarian cancer, cervical and uterine leiomyosarcoma. It has been used an off-label setting for the treatment of advanced endometrial despite lack published data showing efficacy. We performed a retrospective study to determine progression-free survival response rate cancer patients treated with gemcitabine at Memorial Sloan-Kettering Cancer Center. <h3>Methods</h3> Eligible had histologically confirmed...
Asthma is marked by chronic irritation in the airway lumen of lungs due to accretion inflammatory cells that influence regular inhalation process. An extended buildup inflammation leads oxidative pressure and repression antioxidant functions. In current study, a potential compound, boldine, was tested for containment provocative markers along path antiasthmatic activity an ovalbumin (OVA)-induced asthmatic mice model. As effect, boldine (10 20 mg/kg) treatment suppressed such as eosinophil,...
Purpose . To assess if there is a significant difference in enhancement of high grade serous carcinoma the ovary compared with other ovarian malignancies on clinically performed contrast enhanced MRI studies. Methods In this institutional-review–board-approved study, two radiologists reviewed scans 37 patients cancer. Readers measured signal intensity (SI) mass and gluteal fat pre- postcontrast administration. Percentage (PE) was calculated as [(post-pre)/precontrast SI] × 100. Results...
e13810 Background: With the 21st Century Cures Act of 2016, rapid and complete access to medical records including radiology reports is mandated. Patients have expressed that an unmet need improving clarity in results with more structured information avoids technical jargon. RECIST routinely applied clinical trials assess treatment response but challenging apply routine practice. A standardized Oncologic Response (OR) lexicon was developed categorize progression directly from reports, using...