A5058483454- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Renal cell carcinoma treatment
- Advanced X-ray and CT Imaging
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- AI in cancer detection
- Gallbladder and Bile Duct Disorders
- Advanced MRI Techniques and Applications
- Metastasis and carcinoma case studies
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Pancreatitis Pathology and Treatment
- Lung Cancer Diagnosis and Treatment
University of California, San Francisco
2025
Memorial Sloan Kettering Cancer Center
2016-2025
Institute of Medical Sciences
2024-2025
Queen's University
2025
The University of Texas MD Anderson Cancer Center
2025
Qazvin Islamic Azad University
2025
Kettering University
2025
Banaras Hindu University
2025
Louisiana State University
2025
Duke Medical Center
2019-2024
Abstract Comparative protein structure prediction is limited mostly by the errors in alignment and loop modeling. We describe here a new automated modeling technique that significantly improves accuracy of predictions structures. The positions all nonhydrogen atoms are optimized fixed environment with respect to pseudo energy function. sum many spatial restraints include bond length, angle, improper dihedral angle terms from CHARMM‐22 force field, statistical preferences for main‐chain...
International challenges have become the de facto standard for comparative assessment of image analysis algorithms given a specific task. Segmentation is so far most widely investigated medical processing task, but various segmentation typically been organized in isolation, such that algorithm development was driven by need to tackle single clinical problem. We hypothesized method capable performing well on multiple tasks will generalize previously unseen task and potentially outperform...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2,3 . Here a phase I trial adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, we synthesized mRNA real time from surgically resected PDAC tumours. After surgery, sequentially administered atezolizumab (an anti-PD-L1 immunotherapy), cevumeran (a maximum 20 per patient) and...
Semantic segmentation of medical images aims to associate a pixel with label in image without human initialization. The success semantic algorithms is contingent on the availability high-quality imaging data corresponding labels provided by experts. We sought create large collection annotated datasets various clinically relevant anatomies available under open source license facilitate development algorithms. Such resource would allow: 1) objective assessment general-purpose methods through...
Abstract Purpose: Prior molecular profiling of hepatocellular carcinoma (HCC) has identified actionable findings that may have a role in guiding therapeutic decision-making and clinical trial enrollment. We implemented prospective next-generation sequencing (NGS) the clinic to determine whether such analyses provide predictive and/or prognostic information for HCC patients treated with contemporary systemic therapies. Experimental Design: Matched tumor/normal DNA from (N = 127) were analyzed...
B lymphocyte stimulator (BLyS) is a newly identified monocyte-specific TNF family cytokine. It has been implicated in the development of autoimmunity, and functions as potent costimulator with antiimmunoglobulin M cell proliferation vitro. Here we demonstrate that BLyS prominently enhances humoral responses to both T cell-independent cell-dependent antigens, primarily by attenuation apoptosis evidenced prolonged survival antigen-activated cells vivo acts on primary splenic autonomously,...
Transarterial chemoembolization is accepted therapy for hepatocellular carcinoma (HCC). No randomized trial has demonstrated superiority of compared with embolization, and the role chemotherapy remains unclear. This compares outcome embolization using microspheres alone doxorubicin-eluting microspheres.At a single tertiary referral center, patients HCC were randomly assigned to (Bead Block [BB]) or loaded doxorubicin 150 mg (LC Bead [LCB]). Random assignment was stratified by number...
Five percent to 9% of pancreatic ductal adenocarcinomas (PDACs) develop in patients with a germline
<h3>Importance</h3> Unresectable intrahepatic cholangiocarcinoma (IHC) carries a poor prognosis, with median overall survival (OS) of 11 months. Hepatic arterial infusion (HAI) high-dose chemotherapy may have potential benefit in these patients. <h3>Objective</h3> To evaluate clinical outcomes when HAI is combined systemic patients unresectable IHC. <h3>Design, Setting, and Participants</h3> A single-institution, phase 2 trial including 38 was conducted floxuridine plus gemcitabine...
Abstract Somatic mutations in cytosolic or mitochondrial isoforms of isocitrate dehydrogenase (IDH1 IDH2, respectively) contribute to oncogenesis via production the metabolite 2-hydroxyglutarate (2HG). Isoform-selective IDH inhibitors suppress 2HG and induce clinical responses patients with IDH1- IDH2-mutant malignancies. Despite promising activity inhibitors, mechanisms that mediate resistance inhibition are poorly understood. Here, we describe four cases identify mutant isoform switching,...
Adrenocortical carcinomas (ACC) are rare and aggressive malignancies with limited treatment options. This study was undertaken to evaluate the immunogenicity of ACC.Patients advanced ACC were enrolled in a phase II clinical activity pembrolizumab 200 mg every 3 weeks, without restriction on prior therapy. The primary end point objective response rate. Efficacy correlated tumor programmed death-ligand 1 expression, microsatellite-high and/or mismatch repair deficient (MSI-H/MMR-D) status,...
The major ampullate glands of the spider Nephila clavipes contain approximately 0.2 microliter each a highly concentrated (approximately 50%) solution silk fibroin. Therefore, reservoir in these presents an ideal opportunity to observe prefolded conformations protein its native state. To this end, structure and conformation gland fibroin within N. were examined by 13C NMR spectroscopy. These results compared those from first drawn spinneret then denatured. chemical shifts, along with...
BACKGROUND Intrahepatic cholangiocarcinoma (ICC) is associated with poor survival. This study compared the outcomes of patients unresectable ICC treated hepatic arterial infusion (HAI) plus systemic chemotherapy (SYS) SYS alone. METHODS Consecutive were retrospectively reviewed. Clinicopathologic data Survival rates by Kaplan‐Meier analysis and log‐rank testing. RESULTS Between January 2000 August 2012, 525 evaluated at Memorial Sloan Kettering Cancer Center, 236 tumors (locally advanced or...
Purpose To determine the diagnostic performance of intravoxel incoherent motion (IVIM) parameters and apparent diffusion coefficient (ADC) to assess response combined chemotherapy radiation therapy (CRT) in patients with rectal cancer by using histogram analysis derived from whole-tumor volumes single-section regions interest (ROIs). Materials Methods The institutional review board approved this retrospective study 31 who underwent magnetic resonance (MR) imaging before after CRT, including...