A5052970883- Hepatocellular Carcinoma Treatment and Prognosis
- Virus-based gene therapy research
- Healthcare and Venom Research
- Cancer Mechanisms and Therapy
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Complementary and Alternative Medicine Studies
- Toxin Mechanisms and Immunotoxins
- Phytochemistry and Biological Activities
- Flavonoids in Medical Research
- CRISPR and Genetic Engineering
- Traditional Chinese Medicine Analysis
- Immune Cell Function and Interaction
- Plant-based Medicinal Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Herpesvirus Infections and Treatments
- Natural Compounds in Disease Treatment
- Cancer, Hypoxia, and Metabolism
Second Military Medical University
2016-2025
Shanghai University of Traditional Chinese Medicine
2012-2025
Changhai Hospital
2015-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2019
Shanghai Municipal Education Commission
2009-2017
Laboratoire d’immunologie intégrative du cancer
2017
Chinese Academy of Sciences
2008
Army Medical University
2005
Melittin, a water-soluble toxic peptide derived from bee venom of Apis mellifera was reported to have inhibitory effects on hepatocellular carcinoma (HCC). However, its role in antimetastasis and the underlying mechanism remains elusive. By utilizing both HCC cell lines an animal model based assay system, we found that Rac1, which has been shown be involved cancer metastasis, is highly expressed aggressive activity correlated with motility cytoskeleton polymerization. In addition,...
Promoting apoptosis is a strategy for cancer drug discovery. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces in wide range of malignant cells. However, several cancers, including human hepatocellular carcinoma (HCC), exhibit major resistance to TRAIL-induced cell death. Melittin, water-soluble 26-amino acid peptide derived from bee venom Apis mellifera, can exert toxic or inhibitory effects on many types tumor Here we report that melittin induce HCC cells by...
Background: Hypoxia plays an important role in the lung metastasis of hepatocellular carcinoma (HCC). However, process by which hypoxia promotes formation a pre-metastatic niche (PMN) and its underlying mechanism remain unclear. Methods: Exosomes derived from normoxic hypoxic HCC cells were collected to induce fibroblast activation vitro PMN vivo. The micro RNA (miR) profiles exosomes sequenced identify differentially expressed miRNAs. Gain- loss-of-function analyses performed investigate...
Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, they cause debilitating side effects, which limit the use of these compounds. In past decade, many researchers have attempted find so-called dissociated GCs that separate distinct transactivation and transrepression activities. Anti-inflammation is a result glucocorticoid receptor (GR)-mediated in some tissues, similar their effects; therefore, goal discover compound has anti-inflammatory properties, but lacks...
Abstract Background Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Frequent tumor recurrence after surgery related to its poor prognosis. Although gene expression signatures have been associated with outcome, molecular basis of HCC not fully understood, and there no method predict using peripheral blood mononuclear cells (PBMCs), which can be easily obtained for prediction in clinical setting. Methods According microarray analysis results, we constructed a...
Traditional Chinese medicine (TCM) is an important part of the treatment primary liver cancer (PLC) in China; however, current instructions for integrative use traditional and Western PLC are mostly based on expert opinion. There no evidence-based guideline clinical practice this field. Therefore, Shanghai Association Integrative Medicine has established a multidisciplinary working group to develop guideline, which focuses most questions about TCM during treatment. This was developed...
BACKGROUND To explore the clinical efficacy of traditional herbal medicine (THM) in prevention disease recurrence small hepatocellular carcinoma after surgery, a prospective randomized controlled study was conducted between October 2006 and May 2010. The results indicated that THM prevented SHCC with an superior to transarterial chemoembolization (TACE) during median follow‐up 26.61 months. METHODS patients were followed up every 6 months, data before 20, 2015 analyzed. primary outcome...
Efficient tumor targeting has been a great challenge in the clinic for very long time. The traditional methods based on enhanced permeability and retention (EPR) effects show only an ≈5% rate. To solve this problem, new graphene-based cell nuclear fluorescent nanoprobe (GTTN), with tumor-targeting mechanism, is developed. GTTN graphene-like single-crystalline structure amphiphilic probe periphery that functionalized by sulfonic hydroxyl groups. This characteristic of specific targeting, as...
Non-alcoholic fatty liver disease (NAFLD) is a major public health concern worldwide. The aim of the present study was to observe effect diosgenin on NAFLD and investigate underlying mechanisms. Diosgenin treatment increased phosphorylation AMP-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) in HepG2 cells. significantly inhibited high glucose (HG)-induced triglyceride (TG) accumulation sterol regulatory element‑binding protein-1c (SREBP-1c) mRNA increase cells, which were...
Heat stroke (HS) models in rats are associated with severe intestinal injury, which is often considered as the key event at onset of HS. Probiotics can regulate gut microbiota by inhibiting colonization harmful bacteria and promoting proliferation beneficial bacteria. Here, we investigated preventive effects a probiotic Bacillus licheniformis strain (BL, CMCC 63516) on HS well its barrier function microbiota. All were randomly divided into four groups: control (Con) + PBS (pre-administration...
Iron dyshomeostasis is associated with hepatocellular carcinoma (HCC) development. However, the role of iron in HCC metastasis unknown. This study aimed to elucidate underlying mechanisms iron's enhancement activity on metastasis. In addition cell lines and clinical samples vitro, iron-deficient (ID) mouse models were generated using iron-free diet transferrin receptor protein knockout, followed by administration tumors through either orthotopic or ectopic route. Clinical metastatic showed...