A5100399070- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Liver physiology and pathology
- Sexual function and dysfunction studies
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Liver Diseases and Immunity
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- Cancer, Lipids, and Metabolism
- Healthcare and Venom Research
- TGF-β signaling in diseases
- Esophageal and GI Pathology
- Chronic Kidney Disease and Diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Dialysis and Renal Disease Management
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- vaccines and immunoinformatics approaches
- Abdominal Trauma and Injuries
- Fetal and Pediatric Neurological Disorders
First Affiliated Hospital of Soochow University
2022-2025
Southern Medical University
2025
Imperial College London
2025
Zhujiang Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Soochow University
2022-2025
Center for Digestive and Liver Diseases
2025
Zhejiang International Studies University
2024
Zhejiang University
2024
Shanghai University of Traditional Chinese Medicine
2018-2024
AIMTo assess disease-specific circulating microRNAs (miRNAs) in non-alcoholic steatohepatitis (NASH) patients. METHODSA total of 111 biopsy-proven fatty liver disease (NAFLD) or chronic hepatitis B (CHB) patients and healthy controls from mainland China were enrolled to measure their serum levels miR-122, -125b, -146b, -16, -21, -192, -27b -34a.The correlations between miRNAs histological features NAFLD determined.The diagnostic value miRNA NASH significant fibrosis was analyzed compared...
BACKGROUND To explore the clinical efficacy of traditional herbal medicine (THM) in prevention disease recurrence small hepatocellular carcinoma after surgery, a prospective randomized controlled study was conducted between October 2006 and May 2010. The results indicated that THM prevented SHCC with an superior to transarterial chemoembolization (TACE) during median follow‐up 26.61 months. METHODS patients were followed up every 6 months, data before 20, 2015 analyzed. primary outcome...
The baculoviral IAP repeat containing 5 (BIRC5) related to epithelial-mesenchymal transition (EMT) plays a crucial role in the pathogenesis of hepatocellular carcinoma (HCC). However, it remains unclear whether BIRC5-related genes can be used as prognostic markers HCC.Kaplan-Meier (K-M) survival curve was assess Overall Survival (OS) high- and low-expression group divided by median BIRC5 expression. differentially expressed (DEGs) between two groups were screened using limma package,...
Liver fibrosis is the most common pathway in types of chronic liver damage, characterized by an imbalance ECM degradation and synthesis. Saikosaponin-d (SSd) possesses anti-inflammatory anti-fibrotic effects. However, underlying mechanism which SSd represses hepatic stellate cell (HSC) activation remains unclear. Here, we found that remarkably alleviated carbon tetrachloride (CCl4)-induced fibrosis, as evidenced decreased collagen levels profibrotic marker (COl1a1 α-smooth muscle actin...
Rheumatoid arthritis (RA) is a chronic condition characterized by joint pain that significantly impairs patients' work and daily lives. The limited understanding of the pathological mechanisms underlying RA-related poses challenges for effective clinical management. Ganoderma lucidum spore powder (GLSP) has demonstrated therapeutic benefits in various diseases, with no reported toxicity or adverse effects. This study investigates role neutrophils using collagen-induced (CIA) mice an ex vivo...
Abstract Background Acute kidney injury (AKI) exhibits considerable heterogeneity. The objective of current study was to identify AKI subphenotypes in intensive care unit (ICU) patients using multivariate renal function trajectories. Methods A retrospective performed on two independent datasets: the MIMIC-IV and eICU dataset. Using group-based trajectory modeling (GBMTM), we identified based trajectories estimated glomerular filtration rate (eGFR) urine output (Uro). Multivariate cox...
IgA nephropathy (IgAN) is a leading cause of chronic kidney disease, often associated with dyslipidemia and immune dysfunction. This study employs Mendelian randomization (MR) to investigate the causal relationship between plasma lipidomes IgAN, focus on potential mediating role cells. We analyzed 179 genetically predicted IgAN gene using two-sample (TSMR) multivariable MR based summary-level data from genome-wide association study, results were validated by liquid chromatography-mass...
The objective of this study was to investigate the gene expression signature monocyte/macrophages and pleiotropic effects atorvastatin on monocytes in atherosclerotic patients. Forty patients with coronary heart diseases were randomly assigned double‐blind therapy either 20 or 80 mg per day atorvastatin. Follow‐up visits occurred at weeks 6 12, including complete chemistry lipid analyses quantification 14 target genes monocytes. After 12 therapy, both groups gained beneficial alterations...
SLC2A3 is a ferroptosis marker engaged in transmembrane glucose transport. However, the effect of on prognosis patients with cancer remains unclear. This study aimed to explore prognostic implications and its underlying immune mechanisms gastric cancer. The mRNA expression profiles corresponding clinical data were downloaded from Cancer Genome Atlas Gene Expression Omnibus databases. Differentially expressed genes related identified using R package "limma." ontology Kyoto Encyclopedia Genes...
Background/Objectives: Over the past two centuries, tuberculosis (TB) has been responsible for approximately one billion deaths and continues to represent a significant global health challenge. Despite extensive research efforts, fully effective strategies prevention or eradication of TB remain elusive, highlighting urgent demand novel vaccines with enhanced safety profiles efficacy. Lipoproteins, integral surface proteins mycobacteria, are frequently associated virulence display notable...
Background This study aims to explore a deep learning (DL) algorithm for developing prognostic model and perform survival analyses in SBT patients. Methods The demographic clinical features of patients with SBTs were extracted from the Surveillance, Epidemiology End Results (SEER) database. We randomly split samples into training set validation at 7:3. Cox proportional hazards (Cox-PH) analysis DeepSurv used develop models. performance Cox-PH models was evaluated using receiver operating...
Autoimmune hepatitis (AIH) is characterized by chronic progressive liver inflammatory, but there still no safe and effective medicine. Therefore, glucocorticoid remains the top choice for AIH treatment. In previous studies, it has been confirmed that ginsenosides (GSS) can produce glucocorticoid-like effects therapeutic on various autoimmune diseases. However, mechanism of GSS unclear. As an important part innate immune system, bone marrow-derived suppressor cells (MDSC) have identified as...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. In China, traditional Chinese herb medicine has been widely used in treatment HCC. Jiedu Recipe (JR) a prescription which shown good results against However, exact mechanisms JR are still unknown. Therefore, we investigated efficacy on HCC current study. inhibited cell viability both SMMC-7721 and Huh7 cells time- dose-dependent manners. Transwell assay revealed that decreased number migrated cells....
This study was conducted in order to gain a better understanding of the molecular mechanisms stomach adenocarcinoma (STAD), which is necessary predict prognosis STAD and develop novel gene therapy strategies.In this study, expression profile GSE118916 Gene Expression Omnibus (GEO) The Cancer Genome Atlas Program (TCGA) used explore differential co-expression genes normal tissues.A total 407 samples were collected, consisting 375 from tissues 32 tissues, as well RNA-seq count data for 19,600...
The interaction between cancer cells and the tumor microenvironment is of critical importance in liver cancer. Jiedu Granule formula (JDF) has been shown to minimize risk recurrence metastasis following resection. Investigating mechanism underlying therapeutic effects JDF can extend its field application develop novel treatment approaches.
Neuroendocrine neoplasms (NENs) are tumors that originate from secretory cells of the diffuse endocrine system and typically produce bioactive amines or peptide hormones. This paper describes development validation a predictive model risk lymph node metastasis among gastric NEN patients based on machine learning platform.In this investigation, data 1256 were used, whom 119 First Affiliated Hospital Soochow University in China 1137 cases surveillance epidemiology end results (SEER) database...
Our previous studies have demonstrated that some male patients suffering from brachial plexus injury, particularly root avulsion, show erectile dysfunction to varying degrees. However, the underlying mechanism remains poorly understood. In this study, we evaluated function after establishing avulsion models with or without spinal cord injury in rats. After these were established, administered apomorphine (via a subcutaneous injection neck) observe changes function. Rats subjected simple...
Background: Although nonalcoholic fatty liver disease (NAFLD) is related to obesity, it may also affect lean individuals. Recent data suggest that NAFLD patients can develop the whole spectrum of NASH. However, predictive model for populations remains lacking. Methods: A total 5037 individuals were included in this study, and separated training validation. The logistic regression method was used, a nomogram, type prediction model, constructed according analysis significant clinical factors....