A5082163638- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Image Processing Techniques
- Image and Signal Denoising Methods
- Machine Learning and Data Classification
- Image Processing Techniques and Applications
- Advanced Neural Network Applications
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Machine Learning in Materials Science
Texas A&M University
2023-2024
Jinan University
2022-2023
Abstract Cholangiocarcinoma (CCA) is a highly heterogeneous and metastatic malignancy with poor prognosis even after curative hepatectomy. Studies exploring its pathogenesis identifying effective therapeutic targets are urgently needed. In this study, we found that TANK-binding kinase 1 (TBK1), serine/threonine-protein kinase, showed dynamic increase during the different stages of murine spontaneous CCA carcinogenesis (hyperplasia, dysplasia, CCA). TBK1 was upregulated in human tissues,...
This work targets designing a principled and unified training-free framework for Neural Architecture Search (NAS), with high performance, low cost, in-depth interpretation. NAS has been explosively studied to automate the discovery of top-performer neural networks, but suffers from heavy resource consumption often incurs search bias due truncated training or approximations. Recent works Mellor et al. 2021, Chen Abdelfattah 2021 start explore indicators that can predict network's performance...
Early recurrence (within 2 years after resection) is the primary cause of poor outcomes among hepatocellular carcinoma (HCC) patients, and liver cancer stem cells are main contributors to postsurgical HCC recurrence. Nucleolar spindle-associated protein 1 (NUSAP1) has been reported be involved in tumor progression. We investigated function clinical value NUSAP1 early HCC. Data from public datasets our cohort were used assess association between expression Gain- loss-of-function experiments...
In blurry images, the degree of image blurs may vary drastically due to different factors, such as varying speeds shaking cameras and moving objects, well defects camera lens. However, current end-to-end models failed explicitly take into account diversity blurs. This unawareness compromises specialization at each blur level, yielding sub-optimal deblurred images redundant post-processing. Therefore, how specialize one model simultaneously levels, while still ensuring coverage...
Abstract Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy with limited therapeutic options. Metastasis one of the main contributors to ICC progression and poor prognosis. However, underlying mechanism metastasis remains largely unknown. Here, we showed that TANK-binding kinase 1 (TBK1), a serine/threonine-protein kinase, was significantly upregulated in tumor tissues patients larger diameter, lymph node metastasis, advanced TNM stage. Consistently, during...