A5047330126- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Bladder and Urothelial Cancer Treatments
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Gout, Hyperuricemia, Uric Acid
- Curcumin's Biomedical Applications
- Galectins and Cancer Biology
- Cancer Research and Treatments
- Gestational Diabetes Research and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Aldose Reductase and Taurine
- Sirtuins and Resveratrol in Medicine
- Free Radicals and Antioxidants
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Prenatal Substance Exposure Effects
- interferon and immune responses
- Natural product bioactivities and synthesis
Sichuan Academy of Traditional Chinese Medicine
2017-2025
Chengdu University of Traditional Chinese Medicine
2025
Cedars-Sinai Medical Center
2022
Boston Children's Hospital
2020-2021
Harvard University
2020-2021
Jinan University
2012-2016
North China Electric Power University
2015
It is well known that vitamin C could protect against influenza infection, but little about the mechanisms. This study aimed to investigate influence and possible mechanisms of on pneumonia induced by virus in stressed mice. Results showed restraint stress significantly increased mortality severity mice caused A/FM/1/47(H1N1) which was attenuated oral administration (125 250 mg/kg). Moreover, decreased expression susceptibility genes, including mitochondrial antiviral signaling (MAVS)...
The recent emergence and rapid global spread of coronavirus disease 2019 (COVID-19) is leading to public health crises worldwide. Alcohol consumption cigarette smoking (CS) are two known risk factors in many diseases including respiratory infections.We performed a multi-center study the four largest hospitals designated for COVID-19 patients Wuhan. There totally 1547 diagnosed with enrolled study, alcohol CS history were evaluated among these patients. epidemiology, laboratory findings...
Wuwei Shexiang Pill (WSP) is a Tibetan traditional medicine, which has been demonstrated to exhibit potent anti-inflammatory and anti-gout effects. However, the specific pharmacological mechanism not elucidated clearly. In present study, liquid chromatography-mass spectrometry (LC-MS)-based metabolomics was applied investigate alteration of serum metabolites induced by WSP treatment in MSU-induced gouty rats. Subsequently, bioinformatics utilized analyze potential metabolic pathway effect...
In recent decades, natural compounds derived from herbal medicine or dietary sources have played important roles in prevention and treatment of various diseases attracted more attention. Curcumin, extracted the
SHP2 plays a critical role in modulating tumor growth and PD-1-related signaling pathway, thereby serving as an attractive antitumor target. To date, no drugs targeting have been approved, hence, the search of inhibitors with new chemical scaffolds is urgently needed. Herein, we developed novel allosteric inhibitor SDUY038 furanyl amide scaffold, demonstrating potent binding affinity (KD = 0.29 μM), enzymatic activity (IC50 1.2 μM) similar interactions to SHP099. At cellular level, exhibited...
We demonstrate that caffeine could improve HED-induced hepatic steatosis by promoting lipid metabolism <italic>via</italic> the cAMP/CREB/SIRT3/AMPK/ACC pathway. SIRT3 acts as a molecular bridge connecting and metabolism.
Abstract Peptide-drug conjugates (PDCs) have emerged as a promising strategy in cancer therapy, offering improved therapeutic efficacy and reduced toxicity. Compared to antibody-drug (ADCs) small molecule-drug (SMDCs), PDCs possess distinct advantages, such lower immunogenicity, tumor penetration, simpler synthesis. This review discusses the latest advancements PDC design, including novel peptide targeting mechanisms, linker selection, formulation improvements for increased stability....
Oncolytic virus therapy (OVT) represents a promising frontier in cancer treatment. Despite its efficacy clinical trials, variability patient response, particularly resistance development, highlights the need for tailored therapeutic strategies. The Inositol Hexakisphosphate Kinase 2 (IP6K2) gene knock out was carried by CRISPR/Cas9 system. evaluation of biomarkers apoptosis and relevant pathways conducted to be assessed. Attachment assay verify binding ability host cells. Cell proliferation...
Abstract Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder and there no effective cure for this devastating to date. Bushen Yizhi Formula (BSYZ-F), Chinese herbal compound, has proved be AD. In study, we further investigate the part of BSYZ-F, ethyl acetate extract components BSYZ-F (BSYZ-E), protects scopolamine (SCOP)-induced cognitive impairment, which shows similar effect BSYZ-F. We also find that BSYZ-E could protect against SCOP-induced cholinergic system...
Reperfusion therapy is an effective way to rescue cerebral ischemic injury, but this also shows the detrimental risk of devastating disorders and death due possible inflammatory responses involved in pathologies. Hence, ischemia/reperfusion (I/R) injury a great challenge currently. Isorhynchophylline (IRN), tetracyclic oxindole alkaloid extracted from Uncaria rhynchophylla , has previously shown neuroprotective anti-inflammatory effects microglial cells. This study systematically...
The Background: Stroke is one of the leading causes morbidity and mortality, inflammatory mechanism plays a crucial role in stroke-related brain injury post-ischemic tissue damage. Xiaoxuming decoction (XXMD) first prescription for treatment “zhongfeng” (a broad concept referring to stroke) Tang Song Dynasties China has significant position history stroke treatment. Through study ancient medical records modern clinical evidence, it evident that XXMD efficacy its sequelae, pharmacological may...
Three-dimensional cell tissue culture, which produces biological structures termed organoids, has rapidly promoted the progress of research, including basic drug discovery, and regenerative medicine. However, due to lack algorithms software, analysis organoid growth is labor intensive time-consuming. Currently it requires individual measurements using software such as ImageJ, leading low screening efficiency when used for a high throughput screen. To solve this problem, we developed bladder...
Sarcandra glabra , as a type of “antipyretic-detoxicate drugs”, has always been widely used in traditional Chinese medicine (TCM). The extract (SGE) is applied frequently anti-inflammatory and anti-infectious drug folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions susceptible population, we employed restraint stress mouse model investigate effect SGE against influenza. Mice were infected...
Gestational diabetes mellitus (GDM) is one of the leading causes fetal malformations. However, few models have been developed to study underlying mechanisms GDM-induced eye malformation. In this study, high glucose (0.2 mmol/egg) was injected into air sac chick embryo on development day (EDD) 1 develop a hyperglycemia model. Results showed that 47.3 % embryonic malformation happened EDD 5. model, key genes regulating development, Pax6, Six3 and Otx2, were down-regulated by hyperglycemia....