A5103283000- Cancer Immunotherapy and Biomarkers
- Curcumin's Biomedical Applications
- Viral Infections and Vectors
- Natural product bioactivities and synthesis
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Insect symbiosis and bacterial influences
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Mechanisms and Therapy
- Insect and Pesticide Research
- Urinary and Genital Oncology Studies
- Single-cell and spatial transcriptomics
- Tea Polyphenols and Effects
- Phytoestrogen effects and research
- Circular RNAs in diseases
- Thyroid Cancer Diagnosis and Treatment
- Vector-borne infectious diseases
- Melanoma and MAPK Pathways
- Bioactive natural compounds
- Food Quality and Safety Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
Sichuan Academy of Traditional Chinese Medicine
2023-2025
Hubei Provincial Center for Disease Control and Prevention
2012-2025
Sun Yat-sen University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
First Affiliated Hospital of Anhui Medical University
2021-2024
Anhui Medical University
2021-2024
Army Medical University
2018-2023
Ningbo University
2023
Xinqiao Hospital
2018-2023
Laboratoire de Recherche en Sciences Végétales
2020
To define differences in tumor microenvironment immune phenotypes between right and left CRCs explore their therapeutic implications.Gene expression profiling clinical characteristics of patients with colorectal cancer were retrieved from The Cancer Genome Atlas (TCGA) data portal. Immune cell infiltration was estimated based on single sample gene set enrichment analysis (ssGSEA).CRCs tissue microarrays containing 90 consecutive cases surgically-resected samples used for validation....
The present study sought to identify a panel of DNA markers for noninvasive diagnosis using cell-free (cfDNA) from urine supernatant or cellular sediments hematuria patients. A 48 bladder cancer-specific genes was selected. next-generation sequencing-based assay with cfDNA barcode-enabled single-molecule test employed. Mutation profiles blood, urine, and tumor sample 16 cancer patients were compared. Next, urinary prospectively collected 125 (92 cases 33 controls) analyzed the 48-gene panel....
Objective: Detection of aberrant methylated genes in feces has been developed as an early screening method for colorectal cancer.The aim this study was to probe the methylation status SEPT9, BMP3, NDRG4, and SDC2 stool whether these is associated with cancer.Materials Methods: DNAs were isolated purified from cancerous non-cancerous samples cancer tissue.Gene levels quantified by methylation-specific PCR on analyzed a diagnostic model.Results: DNA NDRG4 SDC2, but not had potential detecting...
Eucalypts are the most planted hardwoods worldwide. The availability of Eucalyptus grandis genome highlighted many genes awaiting functional characterization, lagging behind because lack efficient genetic transformation protocols. In order to efficiently generate knock-out mutants study function eucalypts genes, we implemented powerful CRISPR/Cas9 gene editing technology with hairy roots system. As proofs-of-concept, targeted two wood-related genes: Cinnamoyl-CoA Reductase1 (CCR1), a key...
In recent decades, natural compounds derived from herbal medicine or dietary sources have played important roles in prevention and treatment of various diseases attracted more attention. Curcumin, extracted the
Abstract High‐grade serous ovarian carcinomas ( HGSOC s) were among the tumours with an unsatisfactory outcome of immune checkpoint inhibitors ICI s). It is imperative to develop feasible biomarker for identifying responsive candidates and guiding precise immunotherapy patients. Here, we analysed genomic data patients s depict their immunological phenotype tumour microenvironment TME ) figure out major determinants immunogenicity. In comparison other solid tumours, observed lowest levels PD...
Basic fibroblast growth factor (FGF-2) is an important member of the FGF gene family. It widely used in clinical applications for scald and wound healing order to stimulate cell proliferation. Further it applied inhibiting stem differentiation cultures. Due a shortage plasma low expression levels recombinant rbFGF conventional systems, we explored production rice grains (Oryza sativa bFGF, OsrbFGF). An level up 185.66 mg/kg brown was obtained. A simple purification protocol established with...
The NF-κB signaling pathway is overactivated in tumor cells, and the activation of releases a large number inflammatory factors, which enhance immunosuppression promote metastasis. cytochrome P450 (CYP450) system consists important metabolic enzymes present different tissues progressive tumors, may lead to changes pharmacological action drugs diseases such as tumors. In this study, anticancer effect tetrahydrocurcumin (THC), an active metabolite curcumin, on breast cancer cells underlying...
Background: Tick-borne diseases pose a serious disease burden globally, with pathogens including viruses, bacteria, rickettsia, and spirochetes. This study aims to investigate ticks in Huanggang Suizhou, two regions the highest tick-borne prevalence Hubei, China. Methods: A total of 2,958 were collected, their species diversity was characterized. RNA DNA used for polymerase chain reaction detection sequencing Dabie bandavirus (DBV), spotted fever group rickettsioses (SFGR), Coxiella...
Herpes simplex virus type 2 (HSV-2) infects human genital mucosa and establishes life-long latent infection. It is unmet need to establish a cell-based microphysiological system for biology anti-viral drug discovery. One of barriers lacking culture normal epithelial cells in vitro over decades. In this study, we established vaginal cell (HNVEC) using co-culture system. HNVEC were then propagated rapidly stably defined condition. exhibited diploid karyotype formed the well-defined polarized...
Semliki Forest virus capsid (C) protein molecules (Mr, 33,000) can be introduced efficiently into the cytoplasm of various target cells by electroporation, liposome, and erythrocyte ghost-mediated delivery (M. Elgizoli, Y. Dai, C. Kempf, H. Koblet, M.R. Michel, J. Virol. 63:2921-2928, 1989). Here, we show that transferred C partition rapidly from cytosolic compartment nucleus. Transport nucleus was reversibly arrested metabolic inhibitors, indicating transfer process is energy dependent....
A suppressive immune microenvironment and pathological angiogenesis are hallmarks of gastric cancer. Theoretically, checkpoint inhibitors (ICIs) stimulate pre-primed neoantigen-specific T cells, antiangiogenic agents then facilitate their infiltration into the tumor niche by promoting vascular normalization. Currently, interconnections these two phenotypes relevance to (TME) have not been fully characterized in cancer.Transcriptome profiling data retrieved from The Cancer Genome Atlas (TCGA)...
Positive regulators of T cell function play a vital role in the proliferation and differentiation cells. However, their functions gastric cancer have not been explored so far.The TCGA-STAD dataset was utilized to perform consensus clustering order identify subtypes related cell-positive regulators. The prognostic differentially expressed genes these were identified using least absolute shrinkage selection operator (LASSO) regression analysis. To validate robustness signature, verification...
Abstract Background Peripheral blood immunomarkers are associated with prognosis in patients solid tumors receiving chemotherapy or immunotherapy. In this study, the associations of circulating neutrophil‐to‐lymphocyte ratio (NLR), monocyte‐to‐lymphocyte (MLR), and platelet‐to‐lymphocyte (PLR), as well their dynamic changes were investigated relation to efficacy immunotherapy primary liver cancer. Methods Comparisons made between NLR, MLR, PLR among individuals exhibiting disease control...
The Semliki Forest virus capsid (C) protein was introduced into various target cells by electroporation-, liposome-, and erythrocyte-ghost-mediated delivery. Data are presented which show that the incorporated C is biologically active and, at low concentrations (10(3) to 10(4) molecules per cell), markedly induces host cellular synthesis (average value, up 90%). On other hand, high (10(5) 10(6) cell) led a significant inhibition 60%). response found be identical in P3X63Ag8 suspension cells,...
Abstract Background Immune checkpoint inhibitors (ICIs) can improve survivals of metastatic triple negative breast cancer (mTNBC); however, we still seek circulating blood biomarkers to predict the efficacy ICIs. Materials and methods In this study, analyzed data ICIs treated mTNBC collected in Anhui Medical University affiliated hospitals from 2018 2023. The counts lymphocytes, monocytes, platelets, ratio indexes (NLR, MLR, PLR) peripheral were investigated via Kaplan-Meier curves Cox...