A5101718232- Influenza Virus Research Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Respiratory viral infections research
- Viral Infections and Immunology Research
- RNA Research and Splicing
- RNA modifications and cancer
- Inflammasome and immune disorders
- Animal Disease Management and Epidemiology
- Vaccine Coverage and Hesitancy
- Cancer Mechanisms and Therapy
- COVID-19 epidemiological studies
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- Cancer Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Colorectal and Anal Carcinomas
- RNA and protein synthesis mechanisms
- Pneumonia and Respiratory Infections
- Angiogenesis and VEGF in Cancer
- Growth Hormone and Insulin-like Growth Factors
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- interferon and immune responses
Shenzhen Second People's Hospital
2016-2025
Harbin University
2024-2025
Chinese Center For Disease Control and Prevention
2012-2024
University of North Texas
2024
University of North Texas Health Science Center
2024
University of North Texas System
2024
GlaxoSmithKline (United States)
2024
Syracuse University
2024
Sichuan University
2024
Shenzhen University
2021-2024
We report the molecular cloning and characterization of two structurally related putative receptor tyrosine kinases, encoded by distinct genes (tie-1 tie-2) on mouse chromosome 4. Both tie-1 tie-2 encode proteins possessing unique multiple extracellular domains: immunoglobulin-like loop domains flanking three epidermal growth factor repeats followed fibronectin-type III repeats. are expressed in early embryonic vascular system maternal decidual endothelial cells, where vasculature undergoes...
Metformin is a widely used antidiabetic drug for type 2 diabetes that can play cardioprotective role through multiple pathways.It recognized agonist of AMP-activated protein kinase (AMPK) blocks mitochondrial complex I.The NLRP3 inflammasome has been demonstrated to be activated in diabetic cardiomyopathy (DCM).However, the metformin regulating signaling pathway DCM remains unclear.It reported AMPK inhibit by activating autophagy.The aim this study was investigate whether AMPK/mTOR DCM.In...
Abstract Diabetes cardiomyopathy (DCM) is a critical complication of long-term chronic diabetes mellitus and characterized by myocardial fibrosis hypertrophy. It has been suggested that DCM related to pyroptosis, programmed cell death associated with inflammation. The long non-coding RNA Kcnq1ot1 involved in different pathophysiological mechanisms multiple diseases, including acute damage arrhythmia. Our previous study found was elevated left ventricular tissue diabetic mice. However,...
BackgroundThe estimation of influenza-associated excess mortality in countries can help to improve estimates the global burden attributable influenza virus infections. We did a study estimate respiratory mainland China for 2010–11 through 2014–15 seasons.MethodsWe obtained provincial weekly surveillance data and population 161 disease points 31 provinces from Chinese Center Disease Control Prevention years 2005–15. with an annual average rate less than 0·4% between 2005 2015 or 0·3% any...
Circular RNA (circRNA), a subclass of non-coding RNA, plays critical role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as microRNA sponge or scaffold to interact with protein complexes; however, its full range functions remains elusive. Recently, some circRNAs have found coding potential.To investigate the gastric (GC), parallel sequencing was performed using five paired GC samples. Differentially expressed circAXIN1 proposed encode novel protein....
Vascular endothelial cells play essential roles in the function and development of cardiovascular system. However, due to lack lineage-specific markers suitable for molecular biochemical analyses, very little is known about mechanisms that regulate cell differentiation. We report first vascular (including angioblastic precursor cells) 1.2 kb promoter transgenic mice. Moreover, deletion analysis this region embryos revealed multiple elements are required maximum expression. This a powerful...
Diabetic cardiomyopathy (DCM) is a common complication of diabetes and can cause heart failure, arrhythmia sudden death. The pathogenesis DCM includes altered metabolism, mitochondrial dysfunction, oxidative stress, inflammation, cell death extracellular matrix remodeling. Recently, pyroptosis, type programmed related to was proven be activated in DCM. However, the molecular mechanisms underlying pyroptosis remain elusive. long non-coding RNA (lncRNA) Kcnq1ot1 participates many...
Pyroptosis is a caspase-1 dependent programmed cell death, which involved in the pathologic process of several kinds cancers. Loss gene expression has been observed prostate and gastric However, role pyroptosis human hepatocellular carcinoma (HCC) remains largely unknown. The aim this study was to investigate involvement pathogenesis HCC. Our showed that inhibited HCC tissues cells. Administration berberine viability, migration invasion capacity HepG2 cells through induction both vitro vivo,...
Diabetic cardiomyopathy (DCM) is a vital cause of fatalities in diabetic patients. The programmed death cardiomyocytes and inflammation critically contribute to cardiac hypertrophy fibrosis DCM. Furthermore, circular RNA (circRNA) key regulator various diseases. However, the role circRNAs DCM remains be elucidated. Our previous study found that pyroptosis was markedly activated subjected high-glucose conditions, miR-214-3p regulated expression caspase-1. aim this elucidate whether circRNA...
Abstract Human adipose-derived stem cells (hADSCs) are increasingly presumed to be a prospective cell source for replacement therapy in various degenerative and/or traumatic diseases. The potential of trans-differentiating hADSCs into motor neuron indisputably provides an alternative way spinal cord injury (SCI) treatment. In the present study, stepwise and efficient hADSC trans-differentiation protocol with retinoic acid (RA), sonic hedgehog (SHH), neurotrophic factors were developed. With...
Quality of life (QOL) concerns in patients with stomas is a globally important health issue. Currently, lack understanding into which factors influence QOL post-colostomy hinders the ability care professionals to provide appropriate instruction and needed improve patient's QOL. To determine level stoma-specific associate among stoma. A convenience sample 76 was recruited from who presented ward for checkup tertiary hospital Beijing. life, self-care, hope were assessed by Stoma-QOL, stoma...
Background. The pandemic potential of avian influenza viruses A(H5N1) and A(H7N9) remains an unresolved but critically important question.
Human influenza virus infections cause a considerable burden of morbidity and mortality worldwide each year. Understanding regional influenza-associated outpatient is crucial for formulating control strategies against viruses.
Vaccination against
The longevity of an organism is influenced by both genetic and environmental factors. With respect to factors, a significant effort being made identify pharmacological agents that extend lifespan targeting pathways with defined role in the aging process. Sanguinarine (San) benzophenanthridine alkaloid exerts broad spectrum properties. In this study, we utilized Caenorhabditis elegans examine mechanisms which sanguinarine influences innate immunity. We find 0.2 μM extends healthspan C....
MicroRNAs (miRNAs) are small non-coding RNAs that can posttranscriptionally regulate gene expression by targeting messenger RNAs. During miRNA biogenesis, the star strand (miRNA*) is generally degraded to a low level in cells. However, certain miRNA* express abundantly and be recruited into silencing complex expression. Most miRNAs function as suppressive regulators on Group B coxsackieviruses (CVB) major pathogens of human viral myocarditis dilated cardiomyopathy. CVB genome positive-sense,...
Abstract Introduction Growing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived cells (ADSCs) are considered one of most appropriate for However, previous experimental data could not reach an agreement on efficacy ADSC transplantation treating in vivo well its mechanism which hinders their further clinical translational application. Methods To explore hADSC administration neurological...
Lung cancer is one of the most common causes cancer-related deaths worldwide. Although great efforts and progressions have been made in study lung recent decades, mechanism formation remains elusive. To establish effective therapeutic methods, new targets implied processes to be identified. Tripartite motif-containing 25 has associated with ovarian breast thought positively promote cell growth by targeting cycle. However, whether tripartite a function development unknown. In this study, we...