A5106265583- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Enzyme Structure and Function
- Amino Acid Enzymes and Metabolism
- Nerve injury and regeneration
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Microbial Metabolic Engineering and Bioproduction
- Tryptophan and brain disorders
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Biotin and Related Studies
- Neurogenesis and neuroplasticity mechanisms
- Microbial Metabolism and Applications
- Enzyme Production and Characterization
- Biochemical and biochemical processes
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- RNA and protein synthesis mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
University of Iowa
2025
Xi'an Jiaotong University
2022-2024
Ministry of Ecology and Environment
2024
China University of Geosciences
2024
Qingdao Municipal Hospital
2017-2024
Qingdao University
2017-2024
Capital Normal University
2024
Zhejiang Gongshang University
2024
Institute of Zoology
2022-2023
With the deep popularity of mobile Internet, "eyeball economy" is more active than ever. Driven by powerful modern media, livestreaming, as a new form attracting public attention to obtain economic benefits, worth studying its influence path on consumers. Based technology acceptance model and mediating effect emotion, this study constructs consumer influencing factor livestreaming e-commerce. The research related hypotheses are verified SPSS linear multiple regression models. found that...
Recent advancements in modern science have provided robust tools for drug discovery. The rapid development of transcriptome sequencing technologies has given rise to single-cell transcriptomics and single-nucleus transcriptomics, increasing the accuracy accelerating discovery process. With evolution spatial (ST) technology emerged as a derivative approach. Spatial hot topic field omics research recent years; it not only provides information on gene expression levels but also offers...
In this digital age, where parental attention is often diverted by engagement, the phenomenon of “parental phubbing,” defined as parents ignoring their children in favor mobile devices, scrutinized for its potential impact on child development. This study, utilizing questionnaire data from 612 and Structural Equation Modeling (SEM) with moderated mediation, examines association between phubbing young children’s electronic media use. The findings revealed a correlation increased use children....
Fine particulate matter (PM2.5) airborne pollution increases the risk of respiratory and cardiovascular diseases. Although metformin is a well-known antidiabetic drug, it also confers protection against series diseases through activation AMP-activated protein kinase (AMPK). However, whether affects PM2.5-induced adverse health effects has not been investigated. In this study, we exposed wild-type (WT) AMPKα2−/− mice to PM2.5 every other day via intratracheal instillation for 4 weeks. After...
Rostral ventrolateral medulla (RVLM) is thought to serve as a major vasomotor center that participates in controlling the progression of stress-induced hypertension (SIH). Circular RNAs (circRNAs) perform important functions regulation diverse physiological and pathological processes. However, information concerning RVLM circRNAs on SIH remains limited. RNA sequencing was performed profile circRNA expression RVLMs from rats, which were induced by electric foot shocks noises. The Galntl6...
MicroRNAs (miRNAs) are small non-coding RNAs that can posttranscriptionally regulate gene expression by targeting messenger RNAs. During miRNA biogenesis, the star strand (miRNA*) is generally degraded to a low level in cells. However, certain miRNA* express abundantly and be recruited into silencing complex expression. Most miRNAs function as suppressive regulators on Group B coxsackieviruses (CVB) major pathogens of human viral myocarditis dilated cardiomyopathy. CVB genome positive-sense,...
Abstract Background Neuroinflammation in the rostral ventrolateral medulla (RVLM) has been associated with pathogenesis of stress-induced hypertension (SIH). Neuronal mitochondrial dysfunction is involved many pathological and physiological processes. However, impact neuroinflammation on neuronal homeostasis signaling pathway RVLM during SIH are largely unknown. Methods The morphology phenotype microglia injury vivo were analyzed by immunofluorescence, Western blot, RT-qPCR, transmission...
Although the classical redox functions of co-enzyme NAD+ are firmly established in metabolism, there numerous enzymes that catalyze cleavage to yield free ADP-ribose (ADPr) or related metabolites, whose remain largely unknown. Here we show Nudix (nucleoside diphosphate linked another moiety X) hydrolase Ysa1 from Saccharomyces cerevisiae is a major regulator cellular ADPr and O-acetyl-ADP-ribose (OAADPr). OAADPr direct product NAD+-dependent protein deacetylases (sirtuins) readily converted...
Objective. miR-122 is highly abundant in liver and a hepato-specific microRNA. There evidence to show that expression down-regulated human hepatocellular carcinoma (HCC). It not known whether affects the cellular behavior of hepatoma cells. The aim this study was investigate effects on viability apoptosis Material methods. Huh-7 HepG2 cells treated with or antisense RNA (anti-miR-122) were analyzed by adenosine triphosphate (ATP)-based luminescent assay, annexin V-based flow cytometry,...
Cognitive impairment in Alzheimer's disease (AD) is usually accompanied by synaptic loss both the hippocampus and neocortex. In early stage of AD, amyloid β-induced synapse changes main reason, while later stage, accumulation Tau protein promotes degeneration as key factor leading to dementia. MicroRNA (miRNA) closely related expression many AD-related genes. One most abundant brain-enriched miRNAs miR-132, which has been shown regulate neuron morphogenesis plasticity. It reported that...
Abstract Background FMRP is a selective mRNA-binding protein that regulates synthesis at synapses, and its loss may lead to the impairment of trace fear memory. Previously, we found levels in hippocampus rats with post-traumatic stress disorder (PTSD) were decreased. However, mechanism underlying these changes remains unclear. Methods Forty-eight male Sprague-Dawley randomly divided into four groups. The experimental groups treated single-prolonged (SPS) procedure injected...
Neuronal hyperexcitation in the rostral ventrolateral medulla (RVLM) drives heightened sympathetic nerve activity and contributes to etiology of stress-induced hypertension (SIH). Maintenance mitochondrial functions is central neuronal homeostasis. PDZD8, an endoplasmic reticulum (ER) transmembrane protein, tethers ER mitochondria. However, mechanisms PDZD8-mediated ER-mitochondria associations regulating thereby mediating blood pressure (BP) RVLM SIH were largely unknown. rats subjected...
Abstract Aims The rostral ventrolateral medulla (RVLM) is an essential vasomotor center responsible for regulating the development of stress‐induced hypertension (SIH). Long non‐coding RNAs (lncRNAs) play critical roles in various physiopathology processes, but existing research on functions RVLM lncRNAs SIH has been lacking. In this study, we investigated SIH. Methods Genome‐wide lncRNA profiles were determined by RNA sequencing a rat model established using electric foot shocks plus...
Proline 4-hydroxylase 2 (P4HA2) is known for its hydroxylase activity, primarily involved in hydroxylating collagen precursors and promoting cross-linking under physiological conditions. Although overexpression influences a wide variety of malignant tumors' occurrence development, specific effects mechanisms oral squamous cell carcinoma (OSCC) remain unclear. This study focused on investigating the expression patterns, carcinogenic functions, underlying P4HA2 OSCC cells. Various databases,...
Background The RORγt (nuclear receptor retinoid‐related orphan γt) has been identified as a master transcription factor critical for the differentiation of T helper 17 cells, primary source IL‐17A (interleukin‐17A). We previously demonstrated that promotes neuroinflammation and sympathetic excitation, contributing to cardiac dysfunction in heart failure angiotensin II (ANG II)‐induced hypertension. present study sought determine whether inhibiting RORγt, thereby reducing production, could...
Acellular nerve allografts (ANA) possess bioactivity and neurite promoting factors in tissue engineering. Previously we reported that low dose ultrashort wave (USW) radiation could enhance the rate quality of peripheral regeneration with ANA repairing sciatic defects. Meanwhile, implanted bone marrow stromal cells (BMSCs) exhibited a similar result. Thus, it is interesting to know whether might yield synergistic effect when USW combined BMSCs-laden ANA. Here investigated effectiveness seeded...