A5091254040- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- T-cell and Retrovirus Studies
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nuclear Receptors and Signaling
- Developmental Biology and Gene Regulation
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- HIV Research and Treatment
- Molecular Biology Techniques and Applications
Lanzhou University
2024-2025
Oklahoma Medical Research Foundation
2011-2024
Weifang Medical University
2024
First Hospital of Lanzhou University
2024
Liaocheng University
2021-2023
Shaanxi Normal University
2023
University of Oklahoma Health Sciences Center
2004-2022
Sun Yat-sen University
2022
Capital Medical University
2011-2016
State Key Laboratory of Plant Genomics
2013-2015
Full length cDns encoding the glycolyti enzme glyceraldehyde-3-phosphate dehyrogense (GAPDH)fron rat man have been in both genomes based on genmic blot hybridization analysis. Only one functional gene product is know. Result fron genomic library screeings suggest that are 300–400 copies of these sequences genome and approximately 100 human genome, Some realted shown to be thesepseudogenes indicating some pseudogenes transcrined. Rat cDNA 89% homologous coding region, 76% frist base paris 3'...
The obstruction of post-insulin receptor signaling is the main mechanism insulin-resistant diabetes. Progestin and adipoQ 3 (PAQR3), a key regulator inflammation metabolism, can negatively regulate PI3K/AKT pathway. Here, we report that gentiopicroside (GPS), bioactive secoiridoid glycoside Gentiana manshurica Kitagawa, decreased lipid synthesis increased glucose utilization in palmitic acid (PA) treated HepG2 cells. Additionally, GPS improved glycolipid metabolism streptozotocin (STZ)...
The helix-loop-helix transcription factor E2A plays important roles not only in promoting cellular differentiation but also suppressing cell growth. Id proteins, the inhibitors of E2A, have opposite effects on and To understand mechanisms by which suppresses growth, we examined role regulating expression cyclin-dependent kinase inhibitor p21CIP1/WAF1/SD11, prevents cycle progression upon overexpression. By using transient-cotransfection assays luciferase reporter constructs HeLa cells, found...
Ethylene and abscisic acid (ABA) act synergistically or antagonistically to regulate plant growth development. ABA is derived from the carotenoid biosynthesis pathway. Here, we analyzed interplay among ethylene, biogenesis, in rice (Oryza sativa) using ethylene response mutant mhz5, which displays a reduced roots but an enhanced coleoptiles. We found that MHZ5 encodes isomerase mutation mhz5 blocks biosynthesis, reduces accumulation, promotes production etiolated seedlings. can largely...
Epsins are a family of ubiquitin-binding, endocytic clathrin adaptors. Mice lacking both epsins 1 and 2 (Epn1/2) die at embryonic day 10 exhibit an abnormal vascular phenotype. To examine the angiogenic role endothelial epsins, we generated mice with constitutive or inducible deletion Epn1/2 in endothelium. These exhibited no phenotypes under normal conditions, suggesting that lack did not affect blood vessels. In tumors, however, loss resulted disorganized vasculature, significantly...
This study aims to investigate the antitumor effects of saikosaponin A (SSA) on acute myeloid leukemia (AML) and elucidate its underlying mechanisms, particularly focusing endoplasmic reticulum stress (ERS)-mediated MAPK-p-JNK signaling pathway. The inhibitory SSA proliferation AML cell lines K562 HL60 were evaluated using CCK8 EdU assays. Apoptotic induced by analyzed via flow cytometry. RNA sequencing was performed identify differentially expressed genes enriched pathways. Western blot...
B-lymphocyte activation and proliferation induced by the B-cell receptor (BCR) signals are important steps in initiation of humoral immune responses. How BCR translated nuclear transcription factors into cell cycle progression is poorly understood.Id3 an immediate-early gene responding to growth mitogenic many types including B cells. The primary function Id3 protein has been defined as that inhibitor basic-helix-loop-helix (bHLH) factors. interaction between bHLH proteins, which essential...
H9N2 avian influenza viruses are widely prevalent in birds and pose an increasing threat to humans because of their enhanced virulence transmissibility mammals. Active surveillance on the prevalence evolution different hosts will help develop eradication measures. We isolated 16 from chickens, green peafowls, wild eastern China 2017 2019 characterized comparative genetic evolution, receptor-binding specificity, antigenic diversity, replication, transmission chickens mice. The phylogenetic...
The continued evolution and emergence of novel influenza viruses in wild domestic animals poses an increasing public health risk. Two human cases H3N8 avian virus infection China 2022 have caused concern regarding the risk transmission between birds humans. However, prevalence their natural reservoirs biological characteristics are largely unknown. To elucidate potential threat viruses, we analyzed five years surveillance data obtained from important wetland region eastern evaluated...
Id1 is an inhibitor of a group basic helix-loop-helix transcription factors, collectively called E proteins, which includes E12, E47, E2-2, and HEB. We have generated transgenic mice in specifically expressed T cells. The total number thymocytes these less than 4% that wild-type mice. majority the are CD4 CD8 double negative bear cell surface markers multipotent progenitor A small thymocytes, however, differentiate into or single-positive cells, also display different characteristics from...
Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. Here, we demonstrate subsets of these can differentiate from multipotent progenitors and committed T cell precursors thymus, both vivo vitro. These thymic ILC2s exit circulate blood, home to peripheral tissues. Ablation E protein transcription factors greatly promotes ILC fate while impairing B development. Consistently, a transcriptional network centered on ZBTB16 factor IL-4 signaling...
Abstract Innate lymphoid cells (ILCs) are important regulators in various immune responses. The current paradigm states that all newly made ILCs originate from common progenitors the bone marrow. Id2, an inhibitor of E protein transcription factors, is indispensable for ILC differentiation. Unexpectedly, we found ectopically expressing Id1 or deleting two genes thymus drastically increased ILC2 counts and other organs where normally reside. Further evidence suggests a thymic origin these...
The Tal1 oncogene is a class II basic helix-loop-helix (bHLH) transcription factor, overexpressed in as much 60% of T cell acute lymphoblastic leukemia cases. Like other bHLH proteins, can heterodimerize with the I such E47, and bind to DNA recognition sequence termed E box. Therefore, it believed that oncogenic capacity lies its ability, heterodimer activate aberrantly set "leukemogenic" genes cells. However, compared E47 homodimers, Tal1/E47 heterodimers are very poor transactivators. Thus...
Two models have been proposed for the molecular mechanism by which Tal1 oncogene causes T cell acute lymphoblastic leukemia (T-ALL). The activation model suggests that as heterodimers with E2A transcription factor activates expression of oncogenes. inhibition postulates interferes tumor-suppressing function E2A. In Jurkat line, originally derived from a patient T-ALL, is complexed proteins and transcriptional activity very low. When was restored expressing an E2A–Tal1 fusion protein, E-T/2,...
Abstract Multiple subsets of the bone marrow contain T cell precursors, but it remains unclear which is most likely to replenish adult thymus. Therefore, RAG-1+ early lymphoid progenitors (RAG-1+ ELP), and CD62L/L-selectin+ (LSP), as well common from C57BL6-Thy1.1-RAG-1/GFP mouse were directly compared in transplantation assays. The two c-Kithigh populations vigorously regenerated thymus superior magnitude frequency thymic reconstitution. Regeneration was much faster than 22 days described...