A5088061651- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- Cancer-related gene regulation
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- Eosinophilic Esophagitis
- Reproductive System and Pregnancy
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Renal and related cancers
- Chemokine receptors and signaling
- Zebrafish Biomedical Research Applications
- Genomics and Chromatin Dynamics
- Lymphoma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Autoimmune and Inflammatory Disorders Research
- Signaling Pathways in Disease
- Blood disorders and treatments
University of Chicago
2015-2024
Northwestern University
2023
Linköping University
2013
Cancer Research Center
2008-2012
Cancer Research Institute
2006
University of Pennsylvania
2006
University of California, San Diego
1998-2001
Wellesley Institute
1994-1996
Salk Institute for Biological Studies
1996
University of Toronto
1991-1996
The Id2 transcriptional repressor is essential for development of natural killer (NK) cells, lymphoid tissue–inducing (LTi) and secondary tissues. was proposed to regulate NK LTi lineage specification from multipotent progenitors through suppression E proteins. We report that cell are not reduced in the bone marrow (BM) Id2−/− mice, demonstrating specification. Rather, required mature (m) cells. define mechanism by which functions showing a reduction protein activity, deletion E2A, overcomes...
The transcription factors encoded by the E2A and early B cell factor (EBF) genes are required for proper development of lymphocytes. However, absence lineage cells in E2A- EBF-deficient mice has made it difficult to determine function or relationship between these proteins. We report identification a novel model system which role EBF regulation multiple traits can be studied. found that conversion 70Z/3 pre-B lymphocytes with macrophage-like phenotype is associated loss EBF. Moreover, we...
The second messenger cAMP stimulates the expression of a number target genes via protein kinase A-mediated phosphorylation CREB at Ser-133 (Gonzalez, G. A., and Montminy, M. R.(1989) Cell 59, 675-680). enhances activity by promoting interaction with 265-kDa binding referred to as CBP (Arias, J., Alberts, Brindle, P., Claret, F., Smeal, T., Karin, M., Feramisco, M.(1994) Nature 370, 226-228; Chrivia, J. C., Kwok, R. Lamb, N., Hagiwara, R., Goodman, H.(1993) 365, 855-859). mechanism which in...
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The basic helix-loop-helix transcription factors encoded by the E2A gene function at apex of a transcriptional hierarchy involving E2A, early B cell factor (EBF), and Pax5, which is essential for lymphopoiesis. In committed lineage progenitors, proteins have also been shown to regulate many lineage-associated genes. Herein, we demonstrate that block in lymphopoiesis imposed absence can be overcome expression EBF, but not indicating EBF target required development progenitors. Our data...
Id3 is a dominant antagonist of E protein transcription factor activity that induced by signals emanating from the alphabeta and gammadelta T cell receptor (TCR). Mice lacking were previously shown to have subtle defects in positive negative selection TCRalphabeta+ lymphocytes. More recently, Id3(-/-) mice on C57BL/6 background dramatic expansion cells.Here we report reduced thymocyte numbers but increased production cells express Vgamma1.1+Vdelta6.3+ with restricted junctional diversity....
Group 2 innate lymphoid cells (ILC2s) are a subset of ILCs that play protective role in the response to helminth infection, but they also contribute allergic lung inflammation. Here, we report deletion ETS1 transcription factor resulted loss ILC2s bone marrow and lymph nodes promotes fitness common progenitor all ILCs. ETS1-deficient ILC2 progenitors failed up-regulate messenger RNA for E protein inhibitor ID2, critical ILCs, these were unable expand cytokine-driven vitro cultures. In vivo,...
The bacterial community that colonizes mucosal surfaces helps shape the development and function of immune system. K/BxN autoimmune arthritis model is dependent on microbiota, particularly segmented filamentous bacteria, for phenotype. mechanisms how gut microbiota affects are not well understood. In this study, we investigate contribution two T cell subsets, Th17 follicular helper (Tfh), to modulates their differentiation. Using genetic approaches, demonstrate IL-17 dispensable arthritis....