A5101974317- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Congenital Heart Disease Studies
- Neonatal Respiratory Health Research
- Coronary Artery Anomalies
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Particle Dynamics in Fluid Flows
- Advanced Glycation End Products research
- Chromium effects and bioremediation
- Mechanical Circulatory Support Devices
- Cancer Research and Treatments
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Diabetes and associated disorders
- RNA modifications and cancer
- Heavy Metal Exposure and Toxicity
- Infection Control and Ventilation
- Neuroscience of respiration and sleep
University of Chinese Academy of Sciences
2014-2025
University of South China
2013-2025
Shanghai Cancer Institute
2024-2025
XinHua Hospital
2024-2025
Cancer Research Center
2025
Guangzhou University of Chinese Medicine
2023-2024
Zhongshan Hospital
2008-2023
Fudan University
2008-2023
Sun Yat-sen University
2011-2023
The First Affiliated Hospital, Sun Yat-sen University
2011-2023
As important effector cells in inflammation, macrophages can be functionally polarized into either inflammatory M1 or alternatively activated anti-inflammatory M2 phenotype depending on surroundings. The key roles of glycolysis macrophage polarization have been well defined. However, the relationship between and is still poorly understood. Here, we report that 2-deoxy-d-glucose (2-DG), an inhibitor glycolytic pathway, markedly inhibited expressions Arg, Ym-1, Fizz1, CD206 molecules,...
Fine particulate matter (PM2.5) airborne pollution increases the risk of respiratory and cardiovascular diseases. Although metformin is a well-known antidiabetic drug, it also confers protection against series diseases through activation AMP-activated protein kinase (AMPK). However, whether affects PM2.5-induced adverse health effects has not been investigated. In this study, we exposed wild-type (WT) AMPKα2−/− mice to PM2.5 every other day via intratracheal instillation for 4 weeks. After...
Abstract Exposure of airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM2.5) is epidemiologically associated lung dysfunction and respiratory symptoms, including pulmonary fibrosis. However, whether epigenetic mechanisms are involved in PM2.5-induced fibrosis currently poorly understood. Herein, using a mouse model, we found that PM2.5 exposure leads to aberrant mRNA 5-methylcytosine (m5C) gain loss fibrotic tissues. Moreover, showed the m5C-mediated regulatory...
P4HA2 has been implicated in various malignant tumors; however, its expression and functional role colorectal cancer (CRC) remain poorly elucidated. This study aims to investigate the involvement of CRC metastasis progression, uncovering underlying mechanisms. In (CRC), exhibited overexpression, elevated levels were associated with an unfavorable prognosis. Functional assays demonstrated P4HA2's regulation cell proliferation, epithelial–mesenchymal transition (EMT) both vitro vivo....
The increasing incidence of multidrug-resistant (MDR)
Abstract This research demonstrates that DCC-2036 (Rebastinib), a potent third-generation tyrosine kinase inhibitor (TKI), effectively suppresses tumor growth in colorectal cancer (CRC) models with functional immune systems. The findings underscore the capacity of to enhance both activation and cytotoxic functionality CD8 + T cells, which are crucial for facilitating anti-tumor responses. Through comprehensive multi-omics investigations, significant shifts gene protein expression profiles...
Abstract Background and Aims Intestinal obstruction caused by fibrosis is a common serious complication of Crohn's disease (CD). Yes-associated protein (YAP) transcriptional co-activator with PDZ-binding motifs (TAZ), the effectors Hippo signaling pathway, have emerged as key drivers intestinal fibrosis. Systematic inhibition YAP/TAZ failed to combat fibrotic progression, probably due vital epithelial in homeostasis. Methods ELISA immunohistochemical staining were used detect serum...
Significant progress has been made in recent research on air pollutant exposure and respiratory diseases [...]
Tuberculosis (TB), an infectious disease caused by infection of Mycobacterium tuberculosis, is a major public health challenge globally. Genetic epidemiological evidence suggests genetic basis for TB, but the molecular mechanism predisposition to TB remains largely unknown. Thirty-five tag single-nucleotide polymorphisms (SNPs) across 11 candidate cytokines and related genes, including IL-12/IFN-γ axis genes (IL12B, IL12RB1, IL18R1, IL27, IFNGR1, IFNGR2 STAT1), TNF gene locus (TNF LTA),...
This study aimed to evaluate on-pump versus off-pump coronary artery bypass grafting (CABG) in patients with a high-risk operative profile.The pre-, intra- and post-operative data of additive European system for cardiac risk evaluation (additive Euro-SCORE) over 6 undergoing isolated CABG from January 2008 December 2011 this center were investigated retrospectively analyzed. Using the propensity score-matching method, those similar pre- intra-operative characteristics selected their early...
An intra-aortic balloon pump (IABP) is the most commonly used circulatory assist device in cardiac surgery. We hypothesized that prophylactic application of an IABP improves early clinical outcome high-risk patients undergoing scheduled off-pump coronary artery bypass grafting (OPCABG).From January 2010 to December 2013, hemodynamically stable, OPCABG with preincision use were recruited group. Using propensity score-matching method, every patient group was matched another (the control group)...