A5100367730- Lymphatic System and Diseases
- Inflammatory Bowel Disease
- HIV Research and Treatment
- Energy, Environment, Economic Growth
- Urban and Freight Transport Logistics
- Transportation and Mobility Innovations
- Transportation Planning and Optimization
- Evacuation and Crowd Dynamics
- Angiogenesis and VEGF in Cancer
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Digestive system and related health
- IL-33, ST2, and ILC Pathways
- Smart Parking Systems Research
- Aviation Industry Analysis and Trends
- Therapeutic Uses of Natural Elements
- Medical and Biological Ozone Research
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Ocular Oncology and Treatments
- Cancer, Hypoxia, and Metabolism
- Systemic Lupus Erythematosus Research
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
Tongji University
2008-2025
Shanghai Tenth People's Hospital
2017-2025
Guangzhou University
2022
Second Hospital of Anhui Medical University
2021
Anhui Medical University
2014-2021
Tulane University
2014-2021
Tongji Hospital
2008-2013
Abstract Background Creeping fat (CrF) has been recognized to play a positive role in Crohn’s disease (CD) progression, yet the cellular compositions within mesenteric adipose tissue (MAT) and their potential mechanism CrF formation are poorly understood. Methods Analysis of 10X single-cell RNA sequencing was performed on 67 064 cells from 3 pairs surgically resected samples uninvolved MAT. The results were validated another cohort with 6 paired MAT by immunofluorescence. Results All...
Abstract Background and Aims Intestinal obstruction caused by fibrosis is a common serious complication of Crohn's disease (CD). Yes-associated protein (YAP) transcriptional co-activator with PDZ-binding motifs (TAZ), the effectors Hippo signaling pathway, have emerged as key drivers intestinal fibrosis. Systematic inhibition YAP/TAZ failed to combat fibrotic progression, probably due vital epithelial in homeostasis. Methods ELISA immunohistochemical staining were used detect serum...
It is generally known that violent oil price volatility will cause market panic; however, the extent to which worthy of empirical test. Firstly, this paper employs TVP-VAR model analyze time-varying impacts on panic index using monthly data from January 1990 November 2021. Then, after SVAR decompose volatility, uses PDL heterogeneous different sources. Finally, based results decomposition, TARCH asymmetric in directions. The show that: (1) can indeed panic, and these exhibit characteristics;...
Abstract Impairment of the intestinal mucosal immune system is an early feature HIV-infected children. Most infected children exhibit clinical gastrointestinal symptoms at some stage infection, and persistent diarrhea a marker for rapid disease progression. It known that Tregs are especially important in mediating homeostasis loss this subset may result inflammation associated signs. Large numbers FoxP3+ T cells were found all tissues newborn macaques, which coexpressed high levels CD25 CD4,...
Long non-coding RNA (lncRNA) five prime to Xist (FTX) exerts important functions in human cancer, while its role retinoblastoma (RB) remains unclear. This study aimed investigate the of FTX RB. The expression levels were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation was evaluated cell counting kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU) staining and colony formation assays. migration invasion detected Transwell assay. relationship among FTX,...
Abstract Background Postoperative recurrence (POR) remains a major challenge for patients with Crohn’s disease (CD). Gut microbial dysbiosis has been reported to be involved in the pathogenesis of POR. This study aims investigate relationship between fecal microbiome and endoscopic CD after ileocolonic resection. Methods is cross-sectional study. Fecal samples were collected from 52 surgical intervention 6 12 months before examination. Endoscopic was defined as Rutgeerts score ≥ i2. The...
The rapid growth of the intercity travel demand has resulted in enormous pressure on passenger transportation network a megaregion area. Optimally locating hubs and allocating demands to influence effectiveness network. This study develops hierarchical hub location model considering service availability hubs. A mixed integer linear programming formulation was developed minimize total cost operation for multiple determine proportion passengers that access at each level. implemented Wuhan...
The Dual Credit Policy (DCP) is a market-based tradable credit mechanism designed to promote the development of new energy vehicle industry, improve savings, and ultimately achieve carbon emission reduction goals transportation industry. Under DCP, automobile manufacturers (AMs) must meet both corporate average fuel consumption (CAFC) requirement (NEV) requirement. In perfectly competitive market with multiple AMs that produce gasoline vehicles (GVs) and/or (NEVs), we propose mathematical...
When metro system experiences a sudden disruption or at the end of some large-scale gathering events like concerts and carnivals, passenger travel demand would surge immediately within small area bring about severe safety risk. While organized bus bridging services be usually offered in such circumstances to speed up evacuation, many people prefer more comfortable e-hailing service leave area. However, use for speedy evacuation is double-edged sword. On one hand, vehicles supplement buses by...
What influences a firm response to government innovation policies? The stakeholder perspective suggests that firms should commit substantially because the is legitimate and powerful stakeholder. agency some may instead respond opportunistically. This study draws institutional logic reconcile these conflicting arguments. We propose China’s state-owned enterprises, guided by state logic, are more likely make substantial policies. Private market symbolic response. In context of Medium-...