A5100402758- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Carcinogens and Genotoxicity Assessment
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Air Quality and Health Impacts
- interferon and immune responses
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Gout, Hyperuricemia, Uric Acid
- Sulfur Compounds in Biology
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Lipids, and Metabolism
- TGF-β signaling in diseases
- Metabolism, Diabetes, and Cancer
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Chemical Safety and Risk Management
First Affiliated Hospital of Zhengzhou University
2025
Heilongjiang University of Chinese Medicine
2024
Fudan University
2020-2023
Guangzhou Medical University
2023
The Ohio State University
2022
Fudan University Shanghai Cancer Center
2021
Harbin Medical University
2018-2020
Shandong University
2019
Beijing Tian Tan Hospital
2019
Capital Medical University
2019
Abstract Diabetes cardiomyopathy (DCM) is a critical complication of long-term chronic diabetes mellitus and characterized by myocardial fibrosis hypertrophy. It has been suggested that DCM related to pyroptosis, programmed cell death associated with inflammation. The long non-coding RNA Kcnq1ot1 involved in different pathophysiological mechanisms multiple diseases, including acute damage arrhythmia. Our previous study found was elevated left ventricular tissue diabetic mice. However,...
Diabetic cardiomyopathy (DCM) is a common complication of diabetes and can cause heart failure, arrhythmia sudden death. The pathogenesis DCM includes altered metabolism, mitochondrial dysfunction, oxidative stress, inflammation, cell death extracellular matrix remodeling. Recently, pyroptosis, type programmed related to was proven be activated in DCM. However, the molecular mechanisms underlying pyroptosis remain elusive. long non-coding RNA (lncRNA) Kcnq1ot1 participates many...
Switching of vascular smooth muscle cells (VSMCs) from a contractile phenotype to dedifferentiated (proliferative) contributes neointima formation, which has been demonstrated possess tumor-like nature. Dysregulated glucose and lipid metabolism is recognized as hallmark tumors but not thoroughly elucidated in formation. Here, we investigated the cooperative role glycolysis fatty acid synthesis injury-induced VSMC dedifferentiation We found that expression hypoxia-inducible factor-1α (HIF-1α)...
Epigenetic and metabolic reprogramming alterations are two important features of tumors, their reversible, spatial, temporal regulation is a distinctive hallmark carcinogenesis. Epigenetics, which focuses on gene regulatory mechanisms beyond the DNA sequence, new entry point for tumor therapy. Moreover, drives hepatocellular carcinoma (HCC) initiation progression, highlighting significance metabolism in this disease. Exploring inter-regulatory relationship between epigenetic modification has...
Background/Aims: Arsenic trioxide (ATO) is a known anti-acute promyelocytic leukemia (APL) reagent, whose clinical applications are limited by its serious cardiac toxicity and fatal adverse effects, such as sudden death resulting from long QT syndrome (LQTS). The mechanisms of arrhythmia due to ATO exposure still need be elucidated. Long non-coding RNAs (lncRNAs) emerging major regulators various pathophysiological processes. This study aimed explore the involvement lncRNAs in ATO-induced...
Extrahepatic cholangiocarcinoma (eCCA) is a rare but refractory cancer with dense desmoplasia. Prognosis-associated stromal cells in eCCA remain poorly characterized. Here, we profiled the tumor cellular composition and identified prognosis-related signatures by single-cell RNA sequencing (scRNA-seq) eCCA. ECCA patients were further stratified into different categories based on signatures. Using scRNA-seq, transcriptomes of 37,498 individual from eight biopsies, including five tissues three...
To provide a more comprehensive understanding of genotoxic effects from benzene exposure, its on induction mitochondrial DNA copy number (MtDNAcn) and micronucleus (MN) were investigated using peripheral blood workers in China. Changes mtDNAcn MN determined quantitative real-time polymerase chain reaction (PCR) cytokinesis-block assays (CBMN), respectively, 58 control 174 benzene-exposed Shanghai, Among the exposed workers, relative increased then decreased with increasing doses exposure....
Objective: To determine the possibility of early diagnosis and prognosis ovarian cancer (OC) via detecting miR-181a in circulating tumor cells (CTCs) OC to solve clinical difficulties tissue sample collection. Methods: EpCAM liposome magnetic beads (Ep-LMBs) were prepared by reverse-phase evaporation method, performance was characterized. The cytotoxicity assay detected MTT assay, CTC capture efficiency determined using cell lines. Blood samples collected from 30 patients with normal...
To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma reveal the molecular mechanism carcinogenesis.Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases cancer constructed rats. Rats respectively sacrificed at d 14, 28, 56, 77, 105 112 after rats received DENA by gavage, then livers harvested. One part was classified according to their pathological changes, while...
Abstract Tumors evade immune surveillance by creating a hostile environment that impairs the functions of cells. Persistent perturbations including chronic antigen stimulation and metabolic challenges cause endoplasmic reticulum (ER) stress unfolded protein responses (UPR) in T CNPY2 is one key initiators UPR ER, but its roles cell activation persistence have not been reported. Herein, we found expressions other molecules pathways were upregulated both activated exhausted cells, indicating...
<h3>Background</h3> Immune checkpoint inhibition (ICI) has been established as an essential treatment for lung and other cancers. Preclinical studies revealed that DNA-demethylating agents induced type I interferon (IFN-I) response primed the tumor microenvironment (TME) to enhance antitumor immunity.<sup>1 2</sup> However, this promising effect not successfully demonstrated in clinical trials of combined treatments ICI DNA hypomethylation cancer.<sup>3</sup> We hypothesize azacytidine...