A5081767176- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Chronic Disease Management Strategies
- Neonatal Respiratory Health Research
- Biosensors and Analytical Detection
- Tracheal and airway disorders
- Tuberculosis Research and Epidemiology
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Pediatric health and respiratory diseases
- Mycobacterium research and diagnosis
- Obstructive Sleep Apnea Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Monoclonal and Polyclonal Antibodies Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Bacterial Infections and Vaccines
- Bone fractures and treatments
- Misinformation and Its Impacts
- Reconstructive Surgery and Microvascular Techniques
- SARS-CoV-2 detection and testing
- Bacteriophages and microbial interactions
Capital Institute of Pediatrics
2019-2025
Peking University Shenzhen Hospital
2019-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2018-2024
Sun Yat-sen University
2018-2024
Anhui Medical University
2024
Shanghai University of Medicine and Health Sciences
2021-2022
Peking University
2021
Nanchang University
2016-2020
Black AIDS Institute
2020
Guangdong Medical College
2010-2017
Abstract A series of nonpharmaceutical interventions (NPIs) was launched in Beijing, China, on January 24, 2020, to control coronavirus disease 2019. To reveal the roles NPIs respiratory syncytial virus (RSV), specimens collected from children with acute tract infection between July 2017 and Dec 2021 Beijing were screened by capillary electrophoresis‐based multiplex PCR (CEMP) assay. Specimens positive for RSV subjected a polymerase chain reaction (PCR) genotyped G gene sequencing...
The ability of modern web services such as news aggregators and search engines to tailor their results the tastes individuals, together with people's preference for reading opinions which reinforce own viewpoints, have raised concerns that people are nowadays exposed a narrow range view-points, phenomenon referred “filter bubble”. In this paper we focus on increasing exposure varied political goal improving civil discourse. We develop method algorithmically encourage read diverse test it...
To explore the pathogenic agents of acute respiratory infection (ARI) in children Beijing.
Several COVID-19 vaccines have been on the market since early 2021 and may vary in their effectiveness safety. This study characterizes hesitancy about accepting among parents Shanghai, China, identifies how sensitive they are to changes vaccine safety profiles. Schools each township of Minhang District, were sampled, WeChat group school asked participate this cross-sectional Internet-based survey. Parents responded questions given information five different candidates, which varied between...
It is not clear whether the IDSA/ATS minor criteria for severe community-acquired pneumonia (CAP) could be simplified or even modified to orchestrate improvements in predicting mortality. A retrospective cohort study of 1230 CAP patients was performed simplify and modify scoring system by excluding 4 noncontributory infrequent variables (leukopenia, hypothermia, hypotension, thrombocytopenia) these then adding age ≥65 years, respectively. The simplification modification were tested against a...
A series of public health preventive measures has been widely implemented in Beijing to control the coronavirus disease-19 (COVID-19) pandemic since January 2020. An evaluation effects these on spread other respiratory viruses is necessary.Respiratory specimens collected from children with acute infections were tested by NxTAG™ pathogen panel assays during 2017 and December Specimens characterized as rhinoviruses (RVs) sequenced identify RV species types. Then, epidemiology results pathogens...
The heterogeneity of childhood wheezing illnesses is associated with viral and host factors. Human rhinoviruses (HRV) are the major pathogens in severe young children. single nucleotide polymorphism (SNP) rs6967330 G > A proved to heighten risk wheezing. However, relation between variants cadherin-related family member 3 (CDHR3) induced by human rhinovirus (HRV)-C has not been determined. total 11,756 respiratory specimens collected from hospitalized children acute infections (ARIs)...
ABSTRACT With the cancellation of non‐pharmaceutical interventions (NPIs) since December 26, 2022, in Beijing, it is essential to update endemic pattern respiratory syncytial virus (RSV) pediatric patients. Respiratory specimens were collected from hospitalized children with acute infections (ARIs) January 2022 2023 Beijing for multiple pathogen screening. Then, positive RSV subtyped by PCR and genotyped G gene sequencing phylogenetic analysis Mega X. The clinical data only compared using...
Introduction: Validation of compliance with severe sepsis bundles is still needed.The purpose this study was to determine and its outcomes in community-acquired pneumonia (CAP) patients a limited resources country.Material methods: A prospective cohort 212 CAP carried out.The implementation programme organized into two continuous phases.The primary were hospital mortality.Results: Compliance administration antibiotics vasopressors as well plateau pressure on average < 30 cm H 2 O high both...
Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy treating metastatic tumors—particularly, CNS LN metastases—is poor due to inefficient penetration LNs following intravenous injection. We recently reported an delivery of mAb by encapsulating anti-CD20 rituximab (RTX) within thin shell polymer that contains analogues...
Abstract Background The relationship between the Epworth sleepiness scale (ESS) and apnea-hypopnea index (AHI) is uncertain even poor. major problem associated with ESS might be a lack of consideration weight in prediction clinical practice. Would awarding different item-scores to four scales items develop weighted scoring system improve accuracy AHI prediction? It warranted explore intriguing hypotheses. Methods Seven hundred fifty-six adult patients suspicion obstructive sleep apnoea...
Background: The assessment of severity is crucial in the management community-acquired pneumonia (CAP). It remains unknown whether updating cut-off values scoring systems orchestrate improvement predictive accuracy.Methods: 3,212 patients with CAP were recruited to two observational prospective cohort studies. Three bettered derived from corresponding well-established and extensively used pneumonia-specific systems, i.e. index, minor criteria CURB-65 (confusion, urea >7 mmol/L, respiratory...
There were several factors associated with respiratory syncytial virus (RSV) severe acute lower infection (RSV-sALRI) in infants and young children. It is vital to develop a convenient scoring system predict RSV-sALRI Pediatric patients RSV-ALRI from January 2009 December 2021 recruited retrospectively. Two-third of them randomly grouped into the development set one-third validation set. In set, risk for transferred logistic regression analysis, then their receiver operating characteristic...
ObjectivesThe individual 2007 Infectious Disease Society of America (IDSA)/American Thoracic (ATS) minor criteria for severe community-acquired pneumonia (CAP) are unequal weight in predicting mortality. It is not clear whether the combinations predictive findings might imply diverse severities or different mortalities.MethodsA prospective two centre cohort study was performed 385 CAP patients fulfilling three more IDSA/ATS amongst 1430 patients.ResultsHospital mortality rose sharply from...
Introduction:The associations of radiological features with clinical and laboratory findings in Mycoplasma pneumoniae infection are poorly understood.The purpose this study was to assess the associations.Material methods: A retrospective cohort 1230 patients community-acquired pneumonia carried out between January 2005 December 2009.The diagnosis M. made using indirect microparticle agglutinin assay enzyme-linked immunosorbent assay.Results: Females were more susceptible...
Abstract Background Severity of community-acquired pneumonia (CAP) depends on microbial pathogenicity, load and virulence, immune responses. The Infectious Disease Society America the American Thoracic (IDSA/ATS) minor criteria responsible for clinical triage patients with CAP are unequal weight in predicting mortality. It is unclear whether IDSA/ATS major/minor might be strongly positively associated warranted to explore this intriguing hypothesis. Methods A prospective cohort study 404 was...
Background Human bocavirus 1 (HBoV1), first discovered in 2005, was positive symptomatic and healthy children co-detected with other respiratory viruses. It is a long journey to decisively demonstrate the unique viral pathogenic function of acute tract infection (ARTI) pediatric patients. Methods Respiratory specimens collected from patients ARTI January 2017 December 2021 were screened by capillary electrophoresis-based multiplex PCR (CEMP) assay, then genotyped sequencing for HBoV1. For...