A5100409627- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Prostate Cancer Treatment and Research
- Genetic factors in colorectal cancer
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Neonatal Respiratory Health Research
- Prostate Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Lipid metabolism and disorders
- HIV Research and Treatment
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Pleural and Pulmonary Diseases
- Biosensors and Analytical Detection
Fudan University
2018-2025
Zhongshan Hospital
2023-2025
Sichuan University
2019-2025
University of Michigan
2019-2025
University of Chinese Academy of Sciences
2021-2025
First Affiliated Hospital Zhejiang University
2019-2025
Shanghai East Hospital
2024-2025
Tongji University
2024-2025
Xinqiao Hospital
2023-2025
Army Medical University
2023-2025
Abstract Dissecting and understanding the cancer ecosystem, especially that around tumor margins, which have strong implications for cell infiltration invasion, are essential exploring mechanisms of metastasis developing effective new treatments. Using a novel border scanning digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing (Stereo-seq), we identified 500 µm-wide zone centered in patients with liver cancer, referred to as “the invasive zone”. We...
Liver cancer is a malignancy with high morbidity and mortality rates. Serpin family E member 2 (SERPINE2) has been reported to play key role in the metastasis of many tumors. In this study, we aimed investigate potential mechanism SERPINE2 liver metastasis.
Abstract Background Tumor heterogeneity presents a formidable challenge in understanding the mechanisms driving tumor progression and metastasis. The of hepatocellular carcinoma (HCC) cellular level is not clear. Methods Integration analysis single-cell RNA sequencing data spatial transcriptomics was performed. Multiple methods were applied to investigate subtype HCC cells. functional characteristics, translation factors, clinical implications microenvironment associations different subtypes...
Immunologic dysfunction due to coronavirus disease 2019 (COVID-19) is closely related clinical prognosis, and the inflammatory response of pregnant women may affect directional differentiation function fetal immune cells.We sought analyze status newborns from mothers with COVID-19 in third trimester.Along collecting data 51 their respective mothers, we recorded immunophenotypes cytokine immunoglobulin levels newborns.None showed fever or respiratory distress during hospitalization. Detection...
GPR34 is a functional G-protein-coupled receptor of Lysophosphatidylserine (LysoPS), and has pathogenic roles in numerous diseases, yet remains poorly targeted. We herein report cryo-electron microscopy (cryo-EM) structure bound with LysoPS (18:1) G i protein, revealing unique ligand recognition mode the negatively charged head group occupying polar cavity formed by TM3, 6 7, hydrophobic tail residing lateral open groove TM3-5. Virtual screening subsequent structural optimization led to...
Ovarian cancer has a high case fatality rate, but patients who have no visible residual disease after surgery relatively good prognosis. The presence of any cells left in the peritoneal cavity treatment may precipitate recurrence. In many cases, these are occult and not to surgeon. Analysis circulating tumour DNA blood (ctDNA) offer sensitive method predict (non-visible) help We assessed 48 women diagnosed with serous ovarian (47 high-grade 1 low-grade) for ctDNA. Plasma, formalin-fixed...
The hypoglycemic effects of PAS in type-2 diabetic mice (T2D) may be associated with the regulation intestinal microbiota and its metabolic pathways.
Abstract Purpose: Circulating microRNAs (miRNAs) prove to be promising diagnostic biomarkers for various cancers, including endometrial cancer (EC). The present study aims identify serum that can serve as potential EC diagnosis. Patients and methods: A total of 92 102 normal control (NC) samples were analyzed using quantitative real-time polymerase chain reaction (qRT-PCR) in this four-phase experiment. logistic regression method was used construct a model based on the differentially...
Background: The potential functions of Thrombospondin 2 (THBS2) in the progression and immune infiltration gastric cancer (GC) remain unclear. purpose this study was to clarify role THBS2 GC prognosis relationship between cell infiltration. Material Methods: differential expression levels cancer-adjacent tissues were identified using TCGA databases verified real-time polymerase chain reaction (PCR), immunohistochemical staining two datasets from Gene Expression Omnibus (GEO). related...
To study the effects of Bacillus subtilis supplementation in a high-fat diet on gut microbiota and nonalcoholic fatty liver disease grass carp (Ctenopharyngodon idella), juveniles (60 ± 5 g) were fed three diets: (a) control (CON), (b) (HFD) (c) supplemented with B. (HFD + BS). After 8 weeks feeding, fish growth, serum biochemical indices total lipid content measured, analysis was performed using MiSeq250 high-throughput sequencing platform. The results this showed that could improve growth...
Nucleolar and spindle-associated protein 1 (NUSAP1) is a microtubule-associated that plays crucial role in mitosis.Despite initial reports suggesting potential involvement of NUSAP1 tumor progression malignant cell regulation, there has been no systematic analysis its the immune microenvironment, nor predictive value for prognosis immunotherapy response across different cancer types.In this study, we analyze mRNA expression levels various human normal tissues, using data from TCGA, GTEx,...
Reduced supplies of oxygen and nutrients caused by vascular injury lead to difficult-to-heal pressure ulcers (PU) in clinical practice. Rapid repair the skin wound is key resolution this challenge, but measures are still limited. We described beneficial effects extracellular vesicle-derived silk fibroin nanoparticles (NPs) loaded with milk fat globule EGF factor 8 (MFGE8) on accelerating blood vessel PU healing targeting CD13 endothelial cells (VECs).CD13, specific protein NGR, MFGE8, an...
Here, we investigated the roles and mechanisms of flavonoids from mulberry leaves (FML) on lipid metabolism in high fat diet (HFD)-fed mice. ICR mice were fed either a control (Con) or HFD with without FML (240 mg/kg/day) by oral gavage for six weeks. administration improved accumulation, alleviated liver steatosis whitening brown adipose tissue, gut microbiota composition HFD-fed Microbiota transplantation FML-treated HFD-induced metabolic disorders. Moreover, restored production acetic...
Microcystin-LR (MC-LR) is an intracellular toxin with multi-organ toxicity and the testis one of its important target organs. Although there increasing research on MC-LR in male reproductive toxicity, association between DNA damage autophagy induced by germ cells are still unclear. Therefore, it to explore mechanism MC-LR-induced role activated ATM/p53 signaling pathway testicular toxicity. The present study showed that exposure significantly reduced gonadal index pathological testes mice....