A5086417128- Bone Tissue Engineering Materials
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Electrospun Nanofibers in Biomedical Applications
- Bone Metabolism and Diseases
- Medical Imaging and Pathology Studies
- Shoulder Injury and Treatment
- Bioactive natural compounds
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- TGF-β signaling in diseases
- Graphene and Nanomaterials Applications
- Tendon Structure and Treatment
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Pulmonary Hypertension Research and Treatments
- Bone health and treatments
- 3D Printing in Biomedical Research
- Kruppel-like factors research
- Veterinary Equine Medical Research
- Neonatal Respiratory Health Research
- Bone and Joint Diseases
- Alkaloids: synthesis and pharmacology
- Seed and Plant Biochemistry
- Cancer Cells and Metastasis
- Cerebrovascular and genetic disorders
Henan Normal University
2020-2024
Ministry of Agriculture and Rural Affairs
2023
Southern Medical University
2020-2023
Nanfang Hospital
2020-2023
Chengdu University
2014-2023
South Central Minzu University
2016-2021
Sir Run Run Shaw Hospital
2017-2020
Zhejiang University
2005-2020
Blood Center of Zhejiang Province
2019-2020
Hangzhou Xixi hospital
2017
The dysregulation of ROS production and osteoclastogenesis is involved in the progress osteoporosis. To identify novel effective targets to treat this disease, it important explore underlying mechanisms. In our study, we firstly tested effect Nrf2 activator RTA-408, a synthetic triterpenoid under clinical investigation for many diseases, on osteoclastogenesis. We found that could inhibit osteoclast differentiation bone resorption time- dose-dependent manner. Further, RTA-408 enhanced...
Purpose: Given that autologous bone graft for defects is limited by insufficient supply and morbidity at the donor site, developing biomimetic materials as an alternative has gained consistent attention. However, obstacles in designing bone-mimetic could integrate nature of extracellular matrix, osteogenic cells, osteoinductive ingredients with a fast convenient strategy still exist. Methods: This study designed fabricated mesenchymal stem cell (MSC)-laden, nanohydroxyapatite (HAP),...
The endogenous metabolite itaconate has emerged as a regulator of macrophage function that limits inflammation. However, its effect on cell differentiation and osteoclast‐related diseases is unclear. Here, for the first time, we explored cell‐permeable derivative, 4‐octyl (OI) osteoclast in vitro vivo . Firstly, demonstrated concentration was lower estrogen‐deficient mice. OI released induced expression nuclear factor–erythroid 2–related factor 2 (Nrf2) bone marrow–derived macrophages during...
Naringin is a kind of multi-source food additive which has been explored broadly for its various biological activities and therapeutic potential. In the present study, protective effect mechanism naringin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice were investigated. The results showed that significantly alleviated DSS-induced symptoms, including disease activity index (DAI), colon length shortening, pathological damage. tissue serum secretion inflammatory...
This study investigates whether platelet-rich plasma (PRP) is an activator of tendon-derived stem cells (TDSCs) to promote regeneration Achilles tendon post-rupture in rats. In the vitro study, PRGF (activated PRP) significantly enhanced cell DNA synthesis, improved viability and promoted proliferation, while facilitating migration recruitment TDSCs. addition, TDSCs were mixed with collagen PRP form collagen–TDSC constructs (CTC) PRP–collagen–TDSC (PCTCs). After 3 weeks culture vitro, we...
High incidence of osteoporotic fractures emphasizes the necessity developing effective measures to promote osteogenesis. In our study, we investigated a possible role MAPK‐ERK signaling in TGF‐β‐mediated osteoblastic differentiation. Our results indicated that TGF‐β activated pathway and inhibited osteogenesis mesenchymal pluripotent cell line, C3H10T1/2, preosteoblastic MC3T3 cells. And downregulation using pharmacological inhibitor U0126 RNA interference rescued osteoblast differentiation...
Autologous bone grafts are the gold standard for treating defects. However, limited supply and morbidity at donor site restrict its extensive use. Therefore, developing graft materials as an alternative to autologous has gained considerable attention. Injectable hydrogels endowed with osteogenic potential have ability fill irregular defects using minimally invasive procedures thus been attracting researchers' from a clinical perspective, most fabrication methods employed current injectable...
Abstract Background Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function possible mechanisms increased content in pathogenesis IPF remains undetermined. Methods Oil-red staining immunofluorescence analysis were used to detect accumulation mouse lung frozen sections, Bleomycin-treated human type II alveolar epithelial cells (AECIIs) fibroblast. Untargeted Lipid omics was applied...
Abstract Osteosarcoma, the most common bone malignancy, has a high morbidity rate and poor prognosis. Krüppel‐like factor 5 (KLF5) is key transcriptional regulator of cellular proliferation whose overexpression observed in osteosarcoma cell lines (U2OS, 143B, MG63 SAOS2). ML264, small‐molecule inhibitor KLF5, exerts antiproliferative effects colorectal cancer; however, its function remains unknown. Here, we explored possible antitumour ML264 on 143B U2OS murine tumour xenograft model....
Abstract Idiopathic pulmonary fibrosis (IPF) is a lethal progressive fibrotic lung disease. The development of IPF involves different molecular and cellular processes, recent studies indicate that lactate plays significant role in promoting the progression Nevertheless, mechanism by which metabolism regulated downstream effects remain unclear. chaperone CCT6A performs multiple functions variety biological processes. Our research has identified potential association between serum levels...
[This retracts the article DOI: 10.2147/IJN.S270681.].
Psoralen, an active ingredient from Fructus Psoraleae (FP), is used in Traditional Chinese Medicine (TCM) to treat bone diseases. However, the effect of psoralen on cartilage unknown.To investigate effects chondrocytes isolated rats.Chondrocytes were treated with different concentrations (1, 10, and 100 μM) vitro at 3-d 9-d intervals. MTS assay, Alcian blue colorimetry, western blotting, qRT-PCR, respectively, evaluate cell viability, glycosaminoglycan (GAG) synthesis, collagen...
Study Design. Xenograft osteosarcoma mouse model. Objective. We determined the effect of lycorine on osteosarcoma. Summary Background Data. Osteosarcoma is an aggressive malignant neoplasm, most prevalent in teenagers and adults current treatment approaches have reached a survival plateau attempts to improve prognosis proven unsuccessful. Thus there clear evidence that development new agents with high efficacy fewer side effects provide better prognostic outcome urgently needed. Methods. The...
Abstract Osteosarcoma is the most common bone malignancy, and it seriously affects quality of life affected children adolescents. Glabridin (GLA), a major component licorice root extract, has been reported to exert antitumor effects against variety tumor types; however, its on osteosarcoma have not elucidated. In current study, we investigate potential antimetastatic mechanisms GLA in vitro vivo. Flow cytometry showed that induced G2/M cell cycle phase arrest promoted apoptosis. Transwell...
Recruitment of endogenous mesenchymal stem cells (MSCs) has become an attractive strategy for in situ tissue regeneration. However, it is great importance to endow implant with a specific affinity MSCs, many types such as immune and fibroblasts can also be recruited. It been demonstrated that E7 peptides have but their selectivity MSCs when co-cultured other cells, especially flow conditions, rarely investigated. In this study, E7-modified collagen substrates were prepared using...
Pre-harvest sprouting (PHS) will have a serious effect both on the yield and quality of quinoa (<i>Chenopodium quinoa</i> Willd.). It is crucial to select breed varieties with PHS resistance excellent agronomic traits for guidance production utilization quinoa. A comprehensive evaluation 37 species resources was conducted in Chengdu Plain. The used various methods, including grain germination rate (GR), index (GI), total spike (SR), (SI), grey correlation analysis (GCA), cluster analysis....
Abstract During tendon injury, nerve ingrowth is one of the earliest events repair and remodeling. Since peripheral neurons associated cells are mostly derived from neural crest (NC) cells, we sought to investigate role NC‐derived in regeneration. Thus, used Sox10‐Cre/ROSA26‐Flox‐Red Fluorescent Protein (RFP) transgenic mice trace these during After 4 weeks Achilles rupture, injured tissues were harvested for immunohistological analyses, cell isolation, phenotype identification. In addition,...
This study aimed to investigate the extract components of FP on rat chondrocyte function and cartilaginous formation in vitro. Petroleum ether (P-e) was selected treat Sprague-Dawley chondrocytes. Cell viability tested with different concentrations (0.1, 1, 10, 100 μg/mL) P-e treatment. Concentrations 0.1 1 μg/mL conditioned culture mediums were used for treating chondrocytes experiments. proliferation measured via DNA incorporation assay. Type II collagen, aggrecan, Sox-9 genes expression...