A5015743825- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Luminescence Properties of Advanced Materials
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Interference and Gene Delivery
- Electrochemical Analysis and Applications
- Radiation Detection and Scintillator Technologies
- Electrochemical sensors and biosensors
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Medical Imaging and Pathology Studies
- Glass properties and applications
- Pulmonary Hypertension Research and Treatments
- RNA modifications and cancer
- Hydrogen Storage and Materials
- Cytomegalovirus and herpesvirus research
- Traffic control and management
- Advanced Computing and Algorithms
- Chemical Looping and Thermochemical Processes
- S100 Proteins and Annexins
- Ammonia Synthesis and Nitrogen Reduction
- Color Science and Applications
- Phytochemistry and biological activities of Ficus species
- Infrastructure Maintenance and Monitoring
- Immune cells in cancer
Beihang University
2024-2025
The Ohio State University
2020-2025
Henan Normal University
2023-2024
Qinghai Normal University
2024
Beijing Normal University
2024
Wuhan University
2023
University of Chinese Academy of Sciences
2021-2023
Hubei Cancer Hospital
2023
Zhongnan Hospital of Wuhan University
2023
Xiangya Hospital Central South University
2023
Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-associated inflammatory microenvironment aids tumor cells in metastatic colonization lungs. Here, we show that tumor-secreted protease cathepsin C (CTSC) promotes breast-to-lung by regulating recruitment neutrophils and formation neutrophil extracellular traps (NETs). CTSC enzymatically activates membrane-bound proteinase 3 (PR3) to facilitate interleukin-1β (IL-1β) processing nuclear factor κB activation,...
Psoriasis is a chronic skin disease characterized by hyperproliferation and impaired differentiation of epidermal keratinocytes accompanied increased inflammation, suggesting that molecules with antiproliferation anti-inflammatory abilities may be effective for its treatment. One the key steps in regulating cell proliferation DNA replication initiation, which relies on prereplication complex (pre-RC) assembly chromatin. CDC6 an essential regulator pre-RC eukaryotic cells, but role psoriasis...
Immune checkpoint blockade (ICB) therapy targeting PD-1/PD-L1 has shown durable clinical benefits in lung cancer. However, many patients respond poorly to ICB treatment, underscoring an incomplete understanding of PD-L1 regulation and resistance. Here, we find that MTSS1 is downregulated adenocarcinoma, leading upregulation, impairment CD8+ lymphocyte function, enhanced tumor progression. downregulation correlates with improved efficacy patients. Mechanistically, interacts the E3 ligase AIP4...
Abstract Background The molecular mechanism of the significant role long noncoding RNAs (lncRNAs) in progression and metastasis gastric cancer (GC) remains largely elusive. Our objective is to detect overexpressed lncRNA GC investigate its promoting epithelial‐mesenchymal transition tumour microenvironment remodel. Methods LncRNA differential expression profile was analysed using RNA microarrays. level LINC00501 evaluated both patient tissues cell lines by quantitative reverse transcription...
It has been demonstrated that circularRNA (circRNAs) plays a critical role in various cancers. While the potential molecular mechanism of circRNAs progression colorectal cancer (CRC) remains uncertain. Differentially expressed were identified by RNA sequencing. RT-qPCR detected expression circ_0009092, miR-665, and NLK CRC tissues cells. Functions circ_0009092 on tumor cell proliferation, migration, invasion investigated series vitro assays. The underlying was explored bioinformatics...
Abstract Background Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function possible mechanisms increased content in pathogenesis IPF remains undetermined. Methods Oil-red staining immunofluorescence analysis were used to detect accumulation mouse lung frozen sections, Bleomycin-treated human type II alveolar epithelial cells (AECIIs) fibroblast. Untargeted Lipid omics was applied...
Gastric cancer (GC) is a worldwide health problem. Uncovering the underlining molecular mechanisms of GC vital significance. Here, we identified novel oncogene WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) in GC. WWP1 could promote cell proliferation and migration vitro expedite growth vivo. We also found out two microRNAs (miRNAs): miR-129-5p -3p both target WWP1. Interestingly, bound to CDS region mRNA. The miR-129 pairs (miR-129-5p -3p) play pivotal roles suppress its slow...
Abstract Packaging of double-stranded DNA (dsDNA) into viral capsids is crucial in dsDNA viruses, including herpesviruses, adenoviruses, poxviruses, and bacteriophages. An ATPase motor compacts genomes. The phi29 packaging motor, a model system, employs hexameric pRNA (packaging RNA) ring ATPase, sharing revolving mechanism observed herpesvirus genome packaging, bacterial transport, Holliday junction resolution, plasmid conjugation. Channel gating terminates translocation readies reversed...
Abstract Mediated fuel cells (MedFCs) offer a promising alternative to proton exchange membrane by addressing key challenges such as reliance on precious metal catalysts and complex water thermal management through the use of redox mediators efficient oxygen reduction reaction (ORR) facilitators. However, currently available exhibit either low electrochemical activity or insufficient stability, which constrains performance durability these cells. In this study, Dawson‐type...
Abstract Idiopathic pulmonary fibrosis (IPF) is a lethal progressive fibrotic lung disease. The development of IPF involves different molecular and cellular processes, recent studies indicate that lactate plays significant role in promoting the progression Nevertheless, mechanism by which metabolism regulated downstream effects remain unclear. chaperone CCT6A performs multiple functions variety biological processes. Our research has identified potential association between serum levels...
One Stone Two Birds: optically inert ions, especially Li<sup>+</sup>/Gd<sup>3+</sup> co-doping improved upconversion luminescence and temperature sensitivity of ScVO<sub>4</sub>:10%Yb<sup>3+</sup>/2%Er<sup>3+</sup> phosphor.
Magnesium hydroxide (MgH 2 ) has a broad application prospect in solid hydrogen storage, but the associated higher dehydrogenation temperature and undesirable cycling capacity limit its large-scale application.
Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models lung injury but essential for regeneration. Moreover, receptor α (TRα) promotes cell proliferation, TRβ fuels maturation Using a specific agonist, sobetirome, demonstrate anti-fibrotic effects mainly rely on mice. Cellularly, activation enhances alveolar type-2 (AT2) differentiation into AT1...
Nanomotors in nanotechnology may be as important cars daily life. Biomotors are nanoscale machines ubiquitous living systems to carry out ATP-driven activities such walking, breathing, blinking, mitosis, replication, transcription, and trafficking. The sequential action an asymmetrical hexamer by a revolving mechanism has been confirmed dsDNA packaging motors of phi29, herpesviruses, bacterial translocase FtsK, Streptomyces TraB for conjugative transfer. These elaborate, delicate, exquisite...
Post-earthquake road traversability is a critical factor that affects traffic conditions. Therefore, post-earthquake simulation method considering was proposed in this study. First, the impact ranges of earthquake-induced building collapse and fire spread buildings were analyzed, determined accordingly. Subsequently, flow predicted based on characteristics, micro-level vehicle behaviors simulated to determine In addition, model validated using actual data. Finally, segment Tongzhou network...