A5051578140- VLSI and FPGA Design Techniques
- VLSI and Analog Circuit Testing
- 3D IC and TSV technologies
- Advancements in Photolithography Techniques
- Low-power high-performance VLSI design
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- RNA modifications and cancer
- Composting and Vermicomposting Techniques
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Natural product bioactivities and synthesis
- Interconnection Networks and Systems
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Manufacturing Process and Optimization
- Semiconductor materials and devices
- Natural Compounds in Disease Treatment
- Photodynamic Therapy Research Studies
- Parallel Computing and Optimization Techniques
- Guidance and Control Systems
Institute of Physics
2025
Chinese Academy of Sciences
2025
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Union Hospital
2021-2024
Huazhong University of Science and Technology
2021-2024
Hunan Agricultural University
2023-2024
Guangdong Pharmaceutical University
2023
Dhonburi Rajabhat University
2023
The Nesterov's method approach to analytic placement has recently demonstrated strong solution quality and scalability. We dissect the previous implementation strategy show that can be significantly improved using two levers: 1) constraint-oriented local smoothing 2) dynamic step size adaptation. propose a new density function comprehends overflow of area resources; this enables at per-bin granularity. Our adaptation automatically determines effectively allocates optimization effort improve...
We describe the planned Alpha release of OpenROAD, an open-source end-to-end silicon compiler. OpenROAD will help realize goal "democratization hardware design", by reducing cost, expertise, schedule and risk barriers that confront system designers today. The development open-source, self-driving design tools is in itself a "moon shot" with numerous technical cultural challenges. flow incorporates compatible set span logic synthesis, floorplanning, placement, clock tree global routing...
Immunosuppressive M2 macrophages in the tumor microenvironment (TME) can mediate therapeutic resistance of tumors, and seriously affect clinical efficacy prognosis patients. This study aims to develop a novel drug delivery system for dual-targeting inhibit induce macrophage polarization.The anti-tumor effects methyltransferase like 14 (METTL14) were investigated both vitro vivo. The underlying mechanisms METTL14 regulating also explored this study. We further constructed cyclic (Arg-Gly-Asp)...
Rationale: Osteosarcoma (OS) is the most common primary bone tumor with a poor prognosis, but detailed mechanism still unclear.A comprehensive investigation of microenvironment (TME) OS might help find effective anti-tumor strategies.Single-cell transcriptomics powerful new tool to explore TME.Therefore, this study designed investigate TME and gene expression pattern recurrent at single-cell level.Methods: The RNA sequencing bioinformatic analysis were conducted cellular constitution...
Angiogenesis plays a critical role in diabetic wound healing. However, no effective strategies have been developed to target endothelial cells (ECs) facilitate Dapagliflozin (DA) as sodium-glucose linked transporter 2 (SGLT2) inhibitor, may promote neovascularization mice via HIF-1α-mediated enhancement of angiogenesis. Here, the bioinspired nanovesicles (NVs) prepared from induced pluripotent stem cells-derived ECs through an extrusion approach are reported, which can function exosome...
Hypoxia is a common feature within many types of solid tumors, which closely associated with limited efficacy for tumor therapies. Moreover, the inability to reach hypoxic cells that are distant from blood vessels results in tumor-targeting and penetrating drug delivery systems urgent need. Here, glucose oxidase (GOX) hypoxia-activated prodrug tirapazamine (TPZ) loaded into photothermal conversion agent polydopamine (PDA) as glucose/oxygen-exhausting nanoreactor named PGT. We further...
In advanced nodes, routing has become more and complicated. The ISPD-2018 ISPD-2019 Initial Detailed Routing Contests [10] [11] were held to bridge the detailed gap between academia industry by releasing benchmarks using tool libraries. industry-standard LEF/DEF-based benchmark suite inspired a new generation of large-scale academic implementations frameworks considering complex design rules. At same time, efforts such as OpenROAD [1] IEEE CEDA DATC Robust Design Flow (RDF) [3] [8] projects...
Photodynamic therapy (PDT) can produce a large amount of reactive oxygen species (ROS) in the radiation field to kill tumor cells. However, sustainable anti-tumor efficacy PDT is limited due hypoxic microenvironment tumor. In this study, classic agent indocyanine green (ICG) and hypoxia-activated chemotherapeutic drug tirapazamine (TPZ) were loaded on mesoporous polydopamine (PDA) construct [email protected] nanoparticles (PIT). Then, PIT was camouflaged with cyclic...
Detailed routing is a dead-or-alive critical element in design automation tooling for advanced node enablement. However, very few works address detailed the recent open literature, particularly context of modern industrial designs and complete, end-to-end flow. The ISPD-2018 Initial Routing Contest addressed this gap designs, using reduced rules set. In work, we present TritonRoute, an initial router contest. Given route guides from global routing, stage should generate solution honoring as...
Detailed routing is a dead-or-alive critical element in design automation tooling for advanced node enablement. However, very few works address detailed the recent open literature, particularly context of modern industrial designs and complete, end-to-end flow. The ISPD-2018 Initial Routing Contest addressed this gap designs, using realistic rules set. In work, we present TritonRoute, router capable delivering DRC-clean solution. key contributions TritonRoute include an in-memory database,...
Abstract All‐solid‐state lithium‐metal batteries (ASSLMBs) with sulfide solid electrolytes have gained significant attention due to their potential for high energy density and enhanced safety. However, development has been hindered by rapid lithium dendrite growth, low coulombic efficiency, poor battery rate performance, cycling stability, posing a major obstacle commercialization. Herein, multifunctional composite electrolyte (M‐CSE) is reported that dynamically stable metal, promoting...
A retrospective study. This study aims to investigate the relationship between resection of ossification nuchal ligament (ONL), its morphological features, and cervical stability following modified laminoplasty. We retrospectively reviewed data patients diagnosed as degenerative myelopathy (DCM) who underwent laminoplasty with muscle-ligament complex (MLC) reconstruction in our hospital July 2018 October 2022. Demographic information (e.g., age, gender), sagittal parameters, angular...
Routing is a crucial stage in modern design automation tool flow for advanced technology nodes. Works the recent open literature tend to divide routing into separate global (GR) and detailed (DR) steps without addressing correlation issues (e.g., local nets) between these two steps. In this work, we present TritonRoute-WXL (TR-WXL), unified global-detailed router capable of delivering rule check-clean solutions commercial sub-16-nm technologies. The major contributions TR-WXL include an...
Clock network power reduction is critical in modern SoC designs. Application of flop trays (i.e., multi-bit flip-flops) can significantly reduce the number sinks a clock network, and thus buffers, wirelength, power. Shared inverters within also at flip-flop level. However, large-size typically induce placement routing congestion, impose additional constraints on their fanin/fanout logic cones; this results overheads datapaths. At same time, to our knowledge, few previous works have studied...
Power Delivery Network (PDN) is one of the most challenging topics in modern VLSI design. Due to aggressive technology node scaling, resistance back-end-of-line (BEOL) layers increases dramatically sub-10nm VLSI, causing high supply voltage (IR) drop. To solve this problem, pre-placed or post-placed power staples are inserted pin-access connect adjacent rails and reduce PDN resistance, at cost reduced routing flexibility, staple insertion opportunity. In work, we propose dynamic...
The berries of black nightshade (Solanum nigrum L.) are consumed as a favorite fruit in some regions and have been reported to possess range biological activities. Previous studies found that the steroidal saponins from S. (SN) showed potential antileukemic activity, although underlying mechanism remains be revealed. This study investigated effects mechanisms SN combination with adriamycin reverse leukemia multidrug resistance vivo vitro. results indicated displayed enhanced suppression...
Layout-dependent effect causes variation in device performance as well mismatch model-hardware correlation sub-10 nm nodes. In order to effectively explore the power-performance envelope for IC design, cell libraries must provide cells with different diffusion heights, leading neighbor (NDE) due inter-cell height change (diffusion steps). Special filler can protect against steps functional cells, but nontrivial area overhead. this paper, we develop dynamic programming (DP)-based single-row...