A5072791054- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Transplantation Outcomes and Treatments
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Bone Tumor Diagnosis and Treatments
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Vascular Tumors and Angiosarcomas
- Liver Diseases and Immunity
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Cytomegalovirus and herpesvirus research
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- IgG4-Related and Inflammatory Diseases
- Gastric Cancer Management and Outcomes
- Cervical Cancer and HPV Research
- Urologic and reproductive health conditions
- Metastasis and carcinoma case studies
- Musculoskeletal synovial abnormalities and treatments
University of Southern California
2016-2025
Keck Hospital of USC
2020-2023
Southern California University for Professional Studies
2017-2023
Koç University
2022
Marmara University
2022
University of Pittsburgh Medical Center
2022
Yale University
2022
Moffitt Cancer Center
2022
Gangneung Asan Hospital
2022
Michigan Medicine
2022
Allograft rejection is common following clinical organ transplantation, but defining specific immune subsets mediating alloimmunity has been elusive. Calcineurin inhibitor dose escalation, corticosteroids, and/or lymphocyte depleting antibodies have remained the primary options for treatment of episodes. Here, we developed a highly multiplexed imaging mass cytometry panel to study response in archival biopsies from 79 liver transplant (LT) recipients with either no (NR), acute T...
Autoimmune hepatitis (AIH) is an inflammatory liver disease caused by environmental triggers in genetically predisposed patients. Development of acute AIH has been described patients recently infected with viruses such as Epstein–Barr virus (EBV).1 We describe a possible case patient the novel coronavirus 2019 (COVID-19). A 54-year-old man history rheumatoid arthritis (RA) and scleritis presented abdominal pain jaundice. His RA had treated infliximab (500 mg/kg every 8 weeks) for past 10...
Preneoplastic and neoplastic biliary disease comprises intraepithelial neoplasia (BilIN), intraductal papillary neoplasms, mucinous cystic neoplasms (MCNs), cholangiocarcinoma their variants. Correct recognition of these entities can be challenging, especially on small/needle biopsies, but is required to plan therapy guide transplant in the setting cirrhosis. Salient histologic features entities, along with ancillary use immunostains key molecular findings aiding diagnosis, are discussed....
Abstract Primary liver cancer, including hepatocellular carcinoma (HCC) and Cholangiocarcinoma (CCA), arise from the neoplastic transformation of hepatocytes cholangiocytes in liver. Their association with cancer stem-like cell (LCSC) makers presents a more aggressive behavior high lethal rate. PTEN is tumor suppressor gene that negatively regulates PI3K/AKT pathway. Downregulation Pten observed up to 70% cases CCA 50% HCC. In mouse models lacking PTEN, develops 100% mice at 12 months age...
Rejection continues to be an important cause of graft loss in solid organ transplantation, but deep exploration intragraft alloimmunity has been limited by the scarcity clinical biopsy specimens. Emerging single cell immunoprofiling technologies have shown promise discerning mechanisms autoimmunity and cancer immunobiology. Within these applications, Imaging Mass Cytometry (IMC) enable highly multiplexed, analysis immune phenotypes within fixed tissue In this study, IMC panel 10 validated...
Risk stratification of gastrointestinal stromal tumors (GISTs) is based on experience with the stomach, small bowel, and rectum, which are far more common than GISTs other sites. In this study from 47 institutions, we analyzed esophagus (n = 102), colon 136), appendix 27) for their size, mitotic rate, morphology, outcome to determine criteria predict behavior. Esophageal were (median: 2.5 cm) spindle cell morphology a low rate (mean: 3.6/5 mm2). Twelve (12%) progressed, including 11 >5/5 mm2...
Abstract Undifferentiated carcinoma with osteoclast‐like giant cells of the pancreas is rare. Histologically it mimics cell tumor bone and may be associated a ductal adenocarcinoma. We recently encountered two such cases, both which were biopsied by EUS‐guided FNA. Abundant multinucleated many uniform mononuclear present in case 1 so that diagnosis was made. In 2, vacuolated basophilic cytoplasm present, rare seen. A adenocarcinoma no conspicuous nuclear pleomorphism noted or cells. The...
Subjective, varying criteria identify "low-grade" dedifferentiation in well-differentiated/dedifferentiated liposarcoma (WD/DDLPS). The value of mitotic rate (MR) defining DDLPS is not confirmed. We studied all patients with the resection their primary or first recurrence retroperitoneal WD/DDLPS at our institution to determine MR diagnosing and if associates patient survival.
Neutrophils play a crucial role in host defense against infection. Aberrant neutrophil activation may induce tissue damage via sterile inflammation. Neutrophil accumulation has been identified as feature of the inflammatory response observed metabolic dysfunction-associated steatohepatitis (MASH) and associated with liver fibrosis cirrhosis. Here, we performed transcriptomic analysis circulating neutrophils from mild advanced MASH patients to identify potential mechanism behind contribution...
Cutaneous angiosarcoma is a rare complication of chronic lymphedematous extremity (Stewart-Treves syndrome). Early recognition these aggressive tumours important, as they have high incidence local recurrence and metastasis. This report describes the MRI appearance Stewart-Treves syndrome in patient with background lumpectomy, axillary node dissection radiotherapy for breast carcinoma. revealed lobulated cutaneous mass intermediate signal on T(1) weighted imaging, low T(2) diffuse enhancement...