A5075305055- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- T-cell and B-cell Immunology
- Pancreatitis Pathology and Treatment
- DNA and Nucleic Acid Chemistry
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Liver physiology and pathology
- Cytomegalovirus and herpesvirus research
- HIV, Drug Use, Sexual Risk
- Diabetes Management and Research
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Hemoglobinopathies and Related Disorders
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Peroxisome Proliferator-Activated Receptors
- Porphyrin Metabolism and Disorders
- Dialysis and Renal Disease Management
University of Southern California
2020-2025
Second Military Medical University
2020
Keck Hospital of USC
2020
GTx (United States)
2020
Eastern Hepatobiliary Surgery Hospital
2020
Weill Cornell Medicine
2017
Kettering Medical Center
2017
Cornell University
2013-2017
University of Wisconsin–Madison
2011
University of California, San Francisco
2007-2008
Background. The Centers for Disease Control and Prevention (CDC) recommends 1-time hepatitis C virus (HCV) testing in the 1945–1965 birth cohort, addition to targeted risk-based testing. Emergency departments (EDs) are key venues HCV because of population served success HIV screening. We determined burden undocumented infection our ED, providing guidance implementation ED-based
Although the linkage between innate and adaptive immunity in transplantation has been recognized, mechanisms underlying this cooperation remain to be fully elucidated. In study, we show that early "danger" signals associated with lead rapid up-regulation of NKG2D ligands. A second wave ligand is mediated by immune response allografts. Treatment an Ab was highly effective preventing CD28-independent rejection cardiac Notably, blockade did not deplete CD8(+) T cells or NK1.1(+) nor affect...
(COVID-19) has resulted in significant morbidity and mortality solid organ transplant recipients. In December 2020, at the peak of Los Angeles outbreak, our center rapidly implemented a protocol to improve outpatient management provide bamlanivimab or casirivimab-imdevimab [COVID monoclonal antibody (mAb) therapies] all eligible COVID-19 positive liver kidney recipients.A retrospective review abdominal recipients who were polymerase chain reaction between February 2020 2021 from was...
Background. T-cell receptor transgenic (TCR-tg) mouse models with direct CD4+ alloreactivity will help elucidate mechanisms of transplant rejection and tolerance in vivo. Although such exist, they are limited by unusual strain combinations or based on model antigens. Methods. A TCR-tg CD4 specificity the widely used BALB/c donor → C57BL/6 host combination was created. This mouse, named 4C, selected for reactivity against dendritic cells order to early priming events after transplantation....
In kidney transplant recipients, delayed graft function (DGF) increases the risk of failure and mortality. a phase 3, randomized, double-blind, placebo-controlled trial, we investigated hepatocyte growth factor mimetic, ANG-3777 (once daily for 3 consecutive days, starting ≤30 hours posttransplant), in 248 patients receiving first from deceased donor. At day 360, estimated glomerular filtration rate (eGFR; primary endpoint) was not significantly different between placebo groups. There were...
One-third of kidney transplantation patients experience acute injury (AKI) resulting in delayed graft function (DGF), associated with increased risk failure and mortality. Preclinical phase 2 data indicate that treatment ANG-3777 (formerly BB3), a hepatocyte growth factor (HGF) mimetic, may improve long-term reduce health care resource use cost, but these require validation 3 randomized controlled trial.The Graft Improvement Following Transplant (GIFT) trial is multicenter, double-blind...
Biliary complications in liver transplantation (LT) can cause significant morbidity or even lead to a potential graft loss and patient mortality. Oftentimes biliary internal stents (ISs) are used at the time of LT lower risk for prevent these complications; however, their efficacy outcomes remain controversial. A retrospective cohort study was conducted on all adult patients who underwent deceased-donor (DDLT) with an end-to-end choledococholedocostomy. An IS placed across anastomosis,...
Little is known regarding the possible role of social network members and peer attitudes on emergency department (ED) patients' willingness to be tested for HIV. We conducted mixed methods in-depth interview quantitative survey with ED patients from November 2013 June 2014 assess personal perceptions ED-based HIV testing. Patients enrolled were asked about their own toward testing as well those friends. Interviews transcribed categories that captured free responses in verbatim independently...