A5068844132- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Renal and related cancers
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Reproductive Biology and Fertility
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Prenatal Screening and Diagnostics
- Molecular Biology Techniques and Applications
- Cardiac tumors and thrombi
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Pregnancy and preeclampsia studies
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
University of Helsinki
2021-2024
Helsinki University Hospital
2024
Hospital District of Helsinki and Uusimaa
2023
Cedars-Sinai Medical Center
2007-2021
Proton Therapy Centre
2017
Scripps (United States)
2017
University of California, Los Angeles
2012-2017
University of Arkansas for Medical Sciences
2017
Stanford University
2017
Kaiser Permanente West Los Angeles Medical Center
2017
PAX8 is a paired-box gene important in embryogenesis of the thyroid, Müllerian, and renal/upper urinary tracts, expression has been previously described carcinomas from each these sites. However, large study including wide variety epithelial neoplasms multiple organ sites other than kidney, or Müllerian system not performed. The goal this was to evaluate utility immunostaining based on evaluation range tumors. immunohistochemistry performed 1357 tumors (486 whole-tissue sections 871 tissue...
Infection by carcinogenic human papillomaviruses (HPV) results in precancers [cervical intraepithelial neoplasia (CIN)] and cancers near the ectoendocervical squamocolumnar (SC) junction of cervix. However, specific cells targeted HPV have not been identified cellular origin cervical cancer remains elusive. In this study, we uncovered a discrete population SC junctional with unique morphology gene-expression profile. We also demonstrated that selected biomarkers were expressed high...
BACKGROUND Cervical cancer is the second leading cause of deaths among women worldwide. The objective this study was to describe most common oncogenic mutations in cervical cancers and explore genomic differences between 2 histologic subtypes: adenocarcinoma squamous cell carcinoma. METHODS A high‐throughput genotyping platform, termed Oncomap, used interrogate 80 tumors for 1250 known 139 genes. Samples were analyzed using a mass spectrometry‐based platform validated orthogonal chemistry....
Purpose Current staging systems for oral cavity cancers incorporate lymph node (LN) size and laterality, but place less weight on the total number of positive metastatic nodes. We investigated independent impact numerical LN burden survival. Methods Adult patients with squamous cell carcinoma undergoing upfront surgical resection curative intent were identified in National Cancer Data Base between 2004 2013. A neck dissection a minimum 10 LNs was required. Multivariable models constructed to...
Ovarian serous neoplasms can have morphologic overlap with malignant mesothelioma. The distinction is clinically important, yet most studies failed to identify immunostains that reliably distinguish these 2 tumor types. Recently, transcription factor PAX8 was shown be a sensitive and relatively specific marker for Müllerian tumors. In addition, some suggest h-caldesmon mesothelioma when compared ovarian goal of this study evaluate whether expression successfully from Immunohistochemistry...
Nodal staging for laryngohypopharyngeal cancers is based primarily on size and laterality, with less value placed absolute number of metastatic lymph nodes (LNs). We are aware no studies to date that have specifically addressed the prognostic effect quantitative nodal burden in larynx or hypopharynx malignancies.To assess independent impact LN mortality risk.Univariate multivariable models were constructed evaluate association between patients' LNs their survival, adjusting factors such as...
BACKGROUND Multidisciplinary management of head and neck cancer (HNC) must reconcile increasingly sophisticated subspecialty care with timeliness care. Prior studies examined the individual effects delays in diagnosis‐to‐treatment interval, postoperative radiation interval but did not consider them collectively. The objective current study was to investigate combined impact these interwoven intervals on patients HNC. METHODS Patients HNC who underwent curative‐intent surgery were identified...
Background: Phosphatase and tensin homolog deleted on chromosome ten (PTEN)-hamartoma tumor syndrome (PHTS) is a complex disorder caused by germline inactivating mutations of the PTEN suppressor gene. PHTS includes Cowden (CS), Bannayan-Riley-Ruvalcaba (BRRS), Proteus-like syndromes. Affected individuals develop both benign malignant tumors in variety tissues, including thyroid. This study to better characterize describe thyroid pathology within different entities this syndrome, examine...
The purpose of this article is to evaluate MRI features ovarian fibroma and fibrothecoma with histopathologic correlation.In retrospective study, preoperative examinations 35 women (mean age, 49 years; range, 24-86 years) pathologically proven (n = 25) or 10) were reviewed by two radiologists in consensus. features, including visibility ovaries, presence capsule, degeneration, T1 T2 signal, enhancement pattern, recorded correlated features. After administration gadopentetate dimeglumine, the...
Abstract The fallopian tube epithelium (FTE) has been recognized as a site of origin high-grade serous ovarian cancer (HGSC). However, the absence relevant in vitro human models that can recapitulate tissue-specific architecture hindered our understanding FTE transformation and initiation HGSC. Here, induced pluripotent stem cells (iPSCs) were used to establish novel 3-dimensional (3D) organoid model containing cell types well luminal closely reflects organization tissues vivo . Modulation...
The current World Health Organisation classification defines smooth muscle tumours of uncertain malignant potential (STUMPs) as neoplasms that cannot be diagnosed reliably benign or according to generally accepted criteria. This has led the application various sets criteria; consequently, consistent and reliable outcome data are lacking. aims this study were: (i) compare frequency adverse in STUMP on basis enhanced (ii) perform failure analysis identify feature(s) helpful predicting METHODS...
Low-grade cervical squamous abnormalities (low-grade intraepithelial lesions [LSIL, CIN1]) can be confused with or followed by high-grade (HSIL, CIN2/3) lesions, expending considerable resources. Recently, a cell of origin for neoplasia was proposed in the squamocolumnar junction (SCJ); HSILs are almost always SCJ, but LSILs include SCJ and subsets. Abnormal biopsies from 214 patients were classified 2 experienced pathologists (panel) as LSIL HSIL using published criteria. SILs scored...
Ovarian serous borderline tumors (SBTs) are presumed to originate in the ovarian cortex or peritoneal surface. The pathogenetic role of fallopian tube (FT) is unclear; however, recently, secretory cell outgrowths (SCOUTs) lacking PAX2 expression were described benign FTs. This study addressed (1) differentiation characteristics SBTs and (2) frequency SCOUTs FTs patients with compared (3) SCOUT morphology (4) SBTs. FT epithelium shared both ciliated (p73) (HMFG2) differentiation. PAX2-null...
A pattern-based classification for invasive endocervical adenocarcinoma has been proposed as predictive of the risk nodal metastases. We aimed to determine reproducibility such in context common diagnostic challenges: distinction between situ and depth invasion measurement. Nine gynecologic pathologists independently reviewed 96 cases (two slides per case). They diagnosed each case or carcinoma classifying latter following pattern (non-destructive), B (focally destructive) C (diffusely...
Diagnosis of endometrial intraepithelial neoplasia (EIN) requires learning new criteria. Two trainees rendered diagnoses based on biopsy findings, and then measured the effect reviewing PAX2 their interpretation. Fifty-two specimens diagnosed as having EIN were evaluated using Background pattern, altered differentiation, any features complicating diagnosis noted. stains scored confusing, helpful, or noncontributory. cases generated 104 passes; 82% rediagnosed EIN. The was complicated because...
Abstract High-grade extrauterine serous carcinoma (HGSC) is an aggressive tumor with high rates of recurrence, frequent chemotherapy resistance, and overall 5-year survival less than 50%. Beyond determining confirming the diagnosis itself, pathologist review histologic slides provides no prognostic or predictive information, which in sharp contrast to almost all other types. Deep-learning based image analysis has recently been able predict outcome and/or identify morphology-based...
RNA in situ hybridization (RNA-ISH) is a powerful spatial transcriptomics technology to characterize target abundance and localization individual cells. This allows analysis of tumor heterogeneity expression localization, which are not readily obtainable through transcriptomic data analysis. RNA-ISH experiments produce large amounts there need for automated methods. Here we present QuantISH, comprehensive open-source image pipeline that quantifies marker expressions carcinoma, immune,...