A5100750411- Cancer-related molecular mechanisms research
- Plant Pathogens and Resistance
- Plant Disease Resistance and Genetics
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Plant-Microbe Interactions and Immunity
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Potato Plant Research
- Plant Reproductive Biology
- Plant tissue culture and regeneration
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Lung Cancer Diagnosis and Treatment
- Plant nutrient uptake and metabolism
- Lung Cancer Research Studies
- Plant Molecular Biology Research
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- interferon and immune responses
Zhongnan Hospital of Wuhan University
2011-2024
Wuhan University
2012-2024
Huazhong Agricultural University
2005-2017
Nanjing Institute of Vegetable Science
2007-2017
Nankai University
2010
Enhancing radiosensitivity is an important area of investigation for improving breast cancer therapy outcomes. The aim this study was to assess the role miR-15 family in cells. MicroRNAs (miRNAs) encoded by cluster are known induce G1 arrest and apoptosis targeting checkpoints anti-apoptotic B cell lymphoma 2 (BCL-2) gene. However, effect on G2/M remains poorly understood. In current study, cells transfected with miR-15a/15b/16 mimic or inhibitor were irradiated examined by: clonogenic...
HIF-1α overexpression is associated with radioresistance of various cancers. A radioresistant human melanoma cell model MDA-MB-435R (435R) was established by us previously. Compared the parental cells MDA-MB‑435 (435S), an elevated level expression in 435R demonstrated our recent experiments. Therefore, current study, we sought to determine whether selective inhibitors could radiosensitize X-ray, and identify potential mechanisms. Our data that inhibition 2-methoxyestradiol (2-MeOE2)...
Evidences suggest that tumor microenvironment may play an important role in cancer drug resistance. Sphingosine kinase 2 (SphK2) is proposed to be the key regulator of sphingolipid signaling. This study aimed investigate whether combination molecular targeting therapy using a specific inhibitor SphK2 (ABC294640), with necrosis factor-related apoptosis-inducing ligand (TRAIL) can enhance apoptosis non-small cell lung (NSCLC) cells. Our results revealed NSCLC cells' sensitivity TRAIL...
Objectives: MiR-34b is a tumour suppressor in different kinds of carcinomas. This study investigated the role miR-34b proliferation and apoptosis cervical cancer. Materials methods: The expression 60 cancer patients were quantified by RT-PCR correlated with their clinicopathological parameters. Besides, there significant reverse relationship between miR-43b TGF-β1 tissues. Cell was detected CCK-8 assays flow cytometry cell lines transfected mimics. Western blotting, quantitative...
Radiotherapy is one of the major therapeutic strategies for human non-small cell lung cancer (NSCLC), but intrinsic radioresistance cells makes a further improvement radiotherapy NSCLC challenging. Mitochondrial function frequently dysregulated in adaptation to changes tumor microenvironment after exposure radiation. Therefore, targeting mitochondrial biogenesis and bioenergetics an attractive strategy sensitize radiation therapy. In this study, we found that downregulation single-strand...
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a major limitation for its clinical use. The mechanisms of TRAIL resistance have been mostly studied in the context cell lines that are intrinsically resistant TRAIL. However, little known about molecular alterations contribute development acquired during treatment with In this study, we established H460R, an isogenic line resistance, from TRAIL‑sensitive human lung cancer H460 investigate resistance....
We investigated the relationship between significantly different genes of mitochondria-to-nucleus retrograde signaling pathway (RTG) in H1299 ρ0 cells (mtDNA depleted cell) and compared their radiosensitivity to that parental ρ cells, determine possible intervention targets radiosensitization. were mitochondrial DNA by chronic culturing ethidium bromide at low concentration. Radiosensitivity was analyzed using clonogenic assay. Western blot used analyze cell cycle-related proteins,...
To systematically identity microRNA signatures, as well miRNA-gene axes, for lung adenocarcinoma (LUAD) and to explore the potential biomarkers mechanisms associated with LUAD immune responses. LUAD-related data were obtained from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA), these then used identify differentially expressed miRNAs that downregulated in tumor tissues. Summary receiver operating characteristic curve analysis, survival analysis meta-analysis applied evaluate...
Abstract This study constructed a comprehensive analysis of cell death modules in eliminating aberrant cells and remodeling tumor microenvironment (TME). Consensus was performed 490 lung adenocarcinoma (LUAD) patients based on 4 types prognostic genes. Intersection method divided these LUAD samples into 5 risk (CDR) clusters, COX regression were used to construct the CDR signature (CDRSig) with scores. Significant differences TME phenotypes, clinical factors, genome variations,...
Potato (Solanum tuberosum) late blight caused by oomycete Phytophthora infestans (Pi) is highly destructive to potato yield and cost huge losses each year.Regulation of a network transcription machinery, controlled factors (TF's), required overcome the susceptibility.WRKY TF's are known regulate machinery upon biotic abiotic stresses in different crop plants.We cloned characterized WRKY gene, StWRKY1, from cDNA synthesized Pi infested leaves.StWRKY1 protein localized typically...