A5100361494- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Immune Cell Function and Interaction
- Osteoarthritis Treatment and Mechanisms
- Animal Virus Infections Studies
- Treatment of Major Depression
- Boron Compounds in Chemistry
- Tuberous Sclerosis Complex Research
- Advanced Neural Network Applications
- Retinal Imaging and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- Medical Imaging Techniques and Applications
- Congenital Anomalies and Fetal Surgery
- Signaling Pathways in Disease
- Natural Compounds in Disease Treatment
- Hair Growth and Disorders
- Erythropoietin and Anemia Treatment
- Alcoholism and Thiamine Deficiency
- COVID-19 diagnosis using AI
- Hydrogen's biological and therapeutic effects
- Bacterial Identification and Susceptibility Testing
- Boron and Carbon Nanomaterials Research
China Medical University
2024-2025
First Hospital of China Medical University
2023-2025
Yunnan Animal Science and Veterinary Institute
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Peking Union Medical College Hospital
2019-2024
State Key Laboratory of Food Science and Technology
2023-2024
Jiangnan University
2023-2024
Xinjiang University
2024
Peking University
2024
Yunnan Agricultural University
2023-2024
Abstract The random-pattern skin flap is a crucial technique in reconstructive surgery and necrosis caused by ischemia/reperfusion injury major postoperative complication. Herein, we investigated the mechanism of mitophagy induced Melatonin (ML) its effect on survival flaps. Our results demonstrated that ML could activate mitophagy, ameliorate oxidative stress alleviate apoptosis Tert-Butyl hydroperoxide solution (TBHP)-stimulated human umbilical vein endothelial cells vitro. Inhibiting...
Nonalcoholic fatty liver disease (NAFLD) is the most common and important chronic all over world. In present study, we found that koumine, main active ingredient isolated from Gelsemium elegans, has potential therapeutic effect on NAFLD rats by immunomodulatory activity. Koumine could significantly reduce level of TG, TC, LDL-C, ALT, AST in serum increase HDL-C, index, improve adipose-like lesions cells rats. Furthermore, treatment with koumine inhibited severity NAFLD. addition,...
There may be an interaction between viral hepatitis and psychiatric disorders during disease progression. Herein, we conducted Mendelian randomization (MR) to explore the causal associations mediators disorders. Genome-wide association studies summary data for [including chronic B (CHB) C (CHC)] (including depression, anxiety, schizophrenia, obsessive-compulsive disorder, bipolar post-traumatic stress disorder) were obtained. Two-sample MR was performed assess Further, a mediation analysis...
Recent studies have revealed the correlation between serum vitamin D (VD) level and polycystic ovary syndrome (PCOS), but causality specific mechanisms remain uncertain.
Purpose To investigate the longitudinal alterations of retinal microvasculature in patients with primary coronavirus disease 2019 (COVID-19) infection. Methods A cohort participants, who had never been infected COVID-19, was recruited between December 2022 and May 2023 at Peking Union Medical College Hospital Beijing, China. Participants underwent comprehensive ophthalmologic examinations fundus imaging, which included color photography, autofluorescence swept-source optical coherence...
Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome -2 (SARS-CoV-2) has been widely spread in the world with a high mortality. Cytokine storm syndrome (CSS) and acute lung injury SARS-CoV-2 infection severely threaten patients. With purpose to find effective low-toxic drugs mitigate CSS, entecavir imipenem were identified reduce TNF-α using LPS-induced macrophage model from anti-infective drug library. Entecavir efficiently suppressed release of inflammatory...
Bone is the most common site of metastasis prostate cancer (PCa). PCa invasion leads to a disruption osteogenic-osteolytic balance and causes abnormal bone formation. The interaction between stromal cells, especially osteoblasts (OB), considered essential for disease progression. However, drugs that effectively block cancer-bone regulate remain undiscovered.A reporter gene system was constructed screen compounds could inhibit PCa-induced OB activation from 631 compounds. Then,...
The low stability of trans-astaxanthin (AX) not only limits its applications as a functional factor in food systems, but also affects the sensor quality most shrimp products. Therefore, it is important to find an easy, effective way improve physical and chemical AX. In this study, by taking advantage co-existence AX ferritin (Marsupenaeus japonicus ferritin, MjF), we investigated interaction with MjF. Results showed that molecules are able bind on outer surface MjF form complexes,...
Purpose To assess the retinal vasculature changes quantitatively using wide-field optical coherence tomography angiography (OCTA) in systemic lupus erythematosus (SLE), and explore its correlation with clinical features. Design Prospective, cross-sectional, observational study. Participants controls Patients SLE who presented to Ophthalmology Department of Peking Union Medical College Hospital from November 2022 April 2023 were collected. The subjects divided into retinopathy without groups....
Non-ESIPT C-HBTP and ESIPT C-HBTO were designed synthesized through nickel-catalyzed cross-coupling reaction, utilizing o-carborane 2-(2′-hydroxy-phenyl)benzothiazole (HBT) as substrates. The photophysical characteristics of these compounds thoroughly investigated through...
There is little research of psychiatric comorbidity differences among people with different types drug dependence in Chinese population. We explored demographic and comorbid methamphetamine- dependent males (MDs), heroin-dependent (HDs) methamphetamine heroin co-dependent (M/HDs) Hunan province, China.A cross-sectional, structured clinical interview method was used to examine DSM-IV-TR Axis I Disorders 346 MDs, 698 HDs 247 M/HDs from three compulsory rehabilitation centers two voluntary...
The population of young women who suffered from female pattern hair loss (FPHL) or androgenic alopecia (AGA) is gradually increasing. Platelet-rich plasma a novel and promising therapeutic method as nonsurgical treatment for FPHL.
Objective. This study aimed to use multidimensional musculoskeletal ultrasound imaging technique investigate the effect of electroacupuncture (EA) on shoulder subluxation in poststroke patients with hemiplegic pain. Methods. In this prospective single-blind, randomized, sham-controlled study, thirty-four and pain were recruited randomly assigned into EA group or sham (SEA) group. group, was applied Jian yu (LI15), Bi nao (LI14), zhen (SI9), liao (TE14) acupoints. SEA 15 mm away from Lou gu...
Colorectal polyps are abnormal tissues growing on the intima of colon or rectum with a high risk developing into colorectal cancer, third leading cause cancer death worldwide. Early detection and removal via colonoscopy have proved to be an effective approach prevent cancer. Recently, various CNN-based computer-aided systems been developed help physicians detect polyps. However, these do not perform well in real-world operations due significant difference between images real those public...
o -Carborane fluorophores with large Stokes shifts (>14 000 cm −1 ) near-infrared AIE characteristics and self-recovering mechanochromic luminescence.
Group A rotaviruses (RVA) have been identified as the leading cause of neonatal calf diarrhea (NCD) In Yunnan, China, despite limited documentation on this issue within country. Given significant impact animal health and welfare, further attention is warranted to comprehend prevalence epidemiology disease. study, we isolated RVA strains from NCD clinical samples support epidemic study disease control in Yunnan. Material Methods: Ten fecal were obtained calves with a single episode neonate...
Immunodeficiency can disrupt normal physiological activity and function. In this study, donkey bone collagen peptide (DP) its iron chelate (DPI) were evaluated their potential as immunomodulators in cyclophosphamide (Cytoxan®, CTX)-induced Balb/c mice. The femoral tissue, lymphocytes, serum from groups of mice subjected to hematoxylin eosin (H&E) staining, methylthiazolyldiphenyl-tetrazolium bromide (MTT) cell proliferation assays, enzyme-linked immunosorbent assay (ELISA), respectively....