A5038546425- Pharmacogenetics and Drug Metabolism
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Neurotransmitter Receptor Influence on Behavior
- Pharmaceutical studies and practices
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cannabis and Cannabinoid Research
- Plant Diversity and Evolution
- Cancer therapeutics and mechanisms
- Antibiotic Resistance in Bacteria
- Lung Cancer Treatments and Mutations
- Analytical Chemistry and Chromatography
- Epilepsy research and treatment
- Plant and Fungal Species Descriptions
- Drug-Induced Hepatotoxicity and Protection
- Cancer Treatment and Pharmacology
- Pneumonia and Respiratory Infections
- Bipolar Disorder and Treatment
- Antifungal resistance and susceptibility
- Neuropeptides and Animal Physiology
- Statistical Methods in Clinical Trials
- Pharmacological Receptor Mechanisms and Effects
Fudan University
2012-2025
Eye & ENT Hospital of Fudan University
2023
Shanghai Genon Biological Products (China)
2023
University of Otago
2017-2022
Murdoch Children's Research Institute
2020-2021
Peking University
2011-2020
Shanghai Chest Hospital
2020
Shanghai Jiao Tong University
2020
Chinese University of Hong Kong
2016-2018
Pharmac
2018
The concept of "biased agonism" arises from the recognition that ability an agonist to induce a receptor-mediated response (i.e. "efficacy") can differ across multiple signal transduction pathways (e.g. G protein and β-arrestin (βarr)) emanating single GPCR. Despite therapeutic promise biased agonism, molecular mechanism(s) whereby agonists selectively engage signaling remain elusive. This is due in large part challenges associated with quantifying ligand efficacy cells. To address this, we...
A prospective, large library virtual screen against an activated β2-adrenergic receptor (β2AR) structure returned potent agonists to the exclusion of inverse-agonists, providing first complement previous screening campaigns inverse-agonist-bound G protein coupled (GPCR) structures, which predicted only inverse-agonists. In addition, two hits recapitulated signaling profile co-crystal ligand with respect and arrestin mediated signaling. This functional fidelity has important implications in...
As the brain's resident immune cells, microglia perform crucial functions such as phagocytosis, neuronal network maintenance, and injury restoration by adopting various phenotypes. Dynamic imaging of these phenotypes is essential for accessing brain diseases therapeutic responses. Although numerous probes are available pro-inflammatory microglia, no PET tracers have been developed specifically to visualize anti-inflammatory microglia. In this study, we present an 18F-labeled tracer (QTFT)...
ABSTRACT Eravacycline is a broad-spectrum fluorocycline currently approved for complicated intra-abdominal infections (cIAIs). In lung-infection models, it effective against methicillin-resistant Staphylococcus aureus (MRSA) and tetracycline-resistant MRSA. As such, we aimed to develop population pharmacokinetic/pharmacodynamic (PK/PD) model evaluate eravacycline’s pulmonary distribution kinetics. Data were extracted from Phase I study ( NCT01989949 ) which assessed the bronchopulmonary...
Periostin (POSTN), a recently characterised matricellular protein, is frequently dysregulated in various malignant cancers and promotes tumor metastatic growth. POSTN plays critical role the crosstalk between murine breast cancer stem cells (CSCs) their niche to permit colonization. However, whether pro-metastatic capability of associated with multipotent potentials mesenchymal (MSCs) has not been documented. Here we demonstrate that cell-like trait phenotype human mammary epithelial cells....
G-protein coupled receptors (GPCRs) are the primary target class of currently marketed drugs, accounting for about a quarter all drug targets approved medicines. However, almost screening efforts novel ligand discovery rely exclusively on cellular systems overexpressing receptors. An alternative strategy is fragment-based discovery, where low molecular weight compounds, known as fragments, screened initial starting points optimization. fragment libraries usually employs biophysical methods,...
A novel pH activatable near-infrared fluorescence probe was developed, which successfully visualized acidosis in tumors. This holds promise to non-invasively predict the tumor metastasis potential and evaluate therapeutic response.
Schizandrol A (SZA) and schizandrol B (SZB) are two active ingredients of Wuzhi capsule (WZC), a Chinese proprietary medicine commonly prescribed to alleviate tacrolimus (FK-506)-induced hepatoxicity in China. Due their inhibitory effects on cytochrome P450 (CYP) 3A enzymes, SZA/SZB may display drug–drug interaction (DDI) with tacrolimus. To identify the extent this DDI, enzymes’ profiles, including 50% concentration (IC50) shift, reversible inhibition (RI) time-dependent (TDI) were examined...
Ganciclovir and valganciclovir are used for prophylaxis treatment of cytomegalovirus infection. However, there is great interindividual variability in ganciclovir's pharmacokinetics (PK), highlighting the importance individualized dosing. To facilitate model-informed precision dosing (MIPD), this study aimed to establish a parametric model repository ganciclovir by summarizing existing population pharmacokinetic information analyzing sources variability. (2) Methods: A total four databases...
Isoniazid (INH) is a crucial first-line anti tuberculosis (TB) drug used in adults and children. However, various factors can alter its pharmacokinetics (PK). This article aims to establish population pharmacokinetic (popPK) models repository of INH facilitate clinical use.
Abstract Objectives To assess the safety of 4-week daily rifapentine-isoniazid regimen in latent tuberculosis for Chinese children, and to provide paediatric-specific evidence extrapolating adult dosing strategies children. Methods An open-label, prospective, single-arm clinical trial was conducted among eligible patients (aged <10 years old). Rifapentine concentrations laboratory biomarker (total bilirubin) were analysed used population pharmacokinetic-toxicity model development....
Objectives: Birociclib (XZP-3287) is a novel inhibitor of CDK4/6 being developed for the treatment hormone receptor positive human epidermal growth factor 2 Negative (HR+/HER2-) advanced breast cancer (BC). The objectives were to characterize birociclib and its major active metabolites (XZP-3584 XZP-5736) population pharmacokinetic (PPK) behavior, explore exposure-response (ER) relationship plus fulvestrant. Methods: Data from phase 3 study in patients with HR+/HER2- BC, 1/2 studies...
Many standard intermittent dosing regimens for vancomycin in infants fail to achieve the therapeutic target at steady state. This study used population pharmacokinetic (popPK) modelling and simulation determine an optimized regimen, clinically evaluated this regimen aged 0-90 days. An model-based AUC24 of 400-650 mg/L·h was developed from a published popPK model. The PTA achieving as well trough concentration 10-20 mg/L (still commonly clinical practice surrogate AUC24) determined....
Rifampicin is a crucial first-line anti-tuberculosis drug that has been extensively studied through population pharmacokinetic (popPK) analyses. This study aims to construct comprehensive rifampicin popPK model repository support model-informed individualized therapy. A systematic review was conducted using PubMed, Web of Science, and Embase databases up September 2023 retrieve articles on rifampicin. Extracted data included basic information, dosing regimens, sampling strategies,...