A5046591982- Antimicrobial Resistance in Staphylococcus
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Pharmaceutical studies and practices
- Immunotherapy and Immune Responses
- Food Allergy and Anaphylaxis Research
- Neonatal and Maternal Infections
- Insects and Parasite Interactions
- Immune responses and vaccinations
- Autoimmune Neurological Disorders and Treatments
- Global Maternal and Child Health
- Immune Response and Inflammation
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- NMR spectroscopy and applications
- Respiratory and Cough-Related Research
- Calcium signaling and nucleotide metabolism
- Dermatological diseases and infestations
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Drug-Induced Adverse Reactions
- Cytomegalovirus and herpesvirus research
- Rabies epidemiology and control
Royal Children's Hospital
2017-2025
Murdoch Children's Research Institute
2023-2025
The University of Melbourne
2023-2025
Oxford BioMedica (United Kingdom)
2017-2023
University of Oxford
2017-2023
Oxford University Hospitals NHS Trust
2017
Frenchay Hospital
2011
University of Bristol
2011
North Bristol NHS Trust
2011
Many standard intermittent dosing regimens for vancomycin in infants fail to achieve the therapeutic target at steady state. This study used population pharmacokinetic (popPK) modelling and simulation determine an optimized regimen, clinically evaluated this regimen aged 0-90 days. An model-based AUC24 of 400-650 mg/L·h was developed from a published popPK model. The PTA achieving as well trough concentration 10-20 mg/L (still commonly clinical practice surrogate AUC24) determined....
The pediatric population receives the majority of vaccines globally, yet there is a paucity studies on transcriptional response induced by immunization in this special population. In study, we performed systems-level analysis immune responses to trivalent inactivated influenza vaccine adjuvanted with MF-59 children (15-24 months old) and young, healthy adults. We analyzed elicited vaccination peripheral blood, as well cellular antibody following primary booster vaccinations. Our revealed...
Objective Beta-lactam antibiotic allergies are reported in 5%–10% of children; however, up to 90% do not have any reaction at oral challenge test (OCT). This study aimed determine the frequency and identify predictors positive in-hospital graded beta-lactam OCTs children with a allergy label (AAL). Design is retrospective conducted over 7 years, including aged 0–19 years who underwent OCT. The OCT comprised an followed by 5-day outpatient course. Univariate multivariate logistic regression...