A5009124230- Cancer, Hypoxia, and Metabolism
- melanin and skin pigmentation
- Glutathione Transferases and Polymorphisms
- Biochemical effects in animals
- Skin Protection and Aging
- Aldose Reductase and Taurine
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Dermatologic Treatments and Research
- Cardiac Valve Diseases and Treatments
- Metabolism, Diabetes, and Cancer
- Ferroptosis and cancer prognosis
- Hormonal Regulation and Hypertension
- Histone Deacetylase Inhibitors Research
- Sirtuins and Resveratrol in Medicine
- TGF-β signaling in diseases
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Gut microbiota and health
- Immune Cell Function and Interaction
- Venous Thromboembolism Diagnosis and Management
Shenzhen Bay Laboratory
2024-2025
Hefei University of Technology
2025
Affiliated Hospital of Qingdao University
2024
Qingdao University
2024
Capital Medical University
2012-2023
Boston University
2017-2023
Beijing Anzhen Hospital
2009-2023
Massachusetts General Hospital
2020
Harvard University
2020
Drexel University
2012-2016
S-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator ferroptosis, reversibly palmitoylated on cysteine 66. The acyltransferase ZDHHC20 palmitoylates GPX4 increases protein stability. depletion or inhibition palmitoylation by 2-BP sensitizes cancer cells to ferroptosis. Moreover, identify APT2 as depalmitoylase GPX4. Genetic silencing...
Hypoxia-inducible factor 1 (HIF-1) transcriptionally promotes production of adenosine triphosphate (ATP) whereas AMPK senses and regulates cellular energy homeostasis. A histone deacetylase (HDAC) activity has been proven to be critical for HIF-1 activation but the underlying mechanism its role in homesostasis remain unclear. Here, we demonstrate that depends on a cytosolic, enzymatically active HDAC5. HDAC5 knockdown impairs hypoxia-induced HIF-1α accumulation transactivation,...
The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, contrast to leukemia, a protective ultraviolet radiation (UVR)-induced melanoma development. Specifically, the gene is located frequently deleted region and undergoes somatic mutation human melanoma. Specific mutations functionally compromise enzyme activity leading reduced H3K79 methylation. Importantly, absence of DOT1L, UVR-induced DNA damage...
Abstract Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk. Although MC1R signaling is critically dependent on its palmitoylation primarily mediated by the ZDHHC13 protein-acyl transferase, whether increasing represents a viable therapeutic target to limit melanomagenesis in redheads unknown. Here we identify specific and efficient vivo strategy induce benefit. We validate...
Glutamine (Gln) and glucose (Glc) represent two important nutrients for proliferating cells, consistent with the observations that oncogenic processes are associated enhanced glycolysis glutaminolysis. Gln depletion Glc have been shown to trigger growth arrest eventually cell death. Solid tumors often outgrow blood supply, resulting in ischemia, which is hypoxia nutrient insufficiency. Whereas oxygen-sensing adaptive mechanisms well-studied, how cells directly sense respond insufficiency...
Abstract Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC) variants are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylation, primarily mediated by protein acyltransferase zinc finger DHHC-type palmitoyltransferase 13 (ZDHHC13). A better understanding of how ZDHHC13 physiologically activated could help identify approaches to prevent melanomagenesis redheads....
Osteosarcoma is the most common malignancy of bone. HIF-1 (hypoxia-inducible factor 1) activation critical for metabolic reprogramming and progression solid tumors, DEC2 (differentiated embryonic chondrocyte gene 2) has been recently reported to suppress in human breast endometrial cancers. However, roles osteosarcomas remain unclear. We evaluated correlation expression prognosis, studied invasiveness osteosarcoma. Multiple approaches including immunohistochemical staining clinical...
Abstract Ferroptosis is a newly identified cell death triggered by iron‐induced lipid peroxidation. Numerous studies reveal that ferroptosis participates in multiple types of tissue injury including ischaemia–reperfusion (I/R) and doxorubicin (Dox)‐induced damage. Targeting promising approach for disease treatment as the blockade efficiently alleviates symptoms. However, no known inhibitors have been used clinical treatment. Although certain compounds act vitro, whether these drugs cure...
// Chengqian Yin 1 , Dan He Shuyang Chen 1, 4 Xiaoling Tan 2 Nianli Sang 3 Department of Biology, Drexel University College Arts and Sciences, Philadelphia, Pennsylvania, USA High Altitude Physiology, the Third Military Medical University, Chongqing, China Pathology Laboratory Medicine, Dermatology, Boston School Boston, Massachusetts, Correspondence to: Sang, email: ns448@drexel.edu Keywords: ATP, hypoxia, metabolism, pyruvate, NAD + Received: March 30, 2016 ...
Activating mutations in NRAS account for 15–20% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator oncogenic mutations, specifically Q61R and Q61K, which most prevalent melanoma. The genetic ablation or pharmacological inhibition CK1δ markedly destabilizes mutants suppresses their functions. Moreover, identify USP46 a bona fide deubiquitinase mutants. Mechanistically, directly phosphorylates...
Endoplasmic reticulum (ER) stress is a cellular state that results from the overload of unfolded/misfolded protein in ER that, if not resolved properly, can lead to cell death. Both acute lung infections and chronic diseases have been found related stress. Yet no study has presented integrating metabolomic transcriptomic data total interpreting pathogenic Total mouse lungs were used perform LC-MS RNA sequencing relevance Untargeted metabolomics revealed 16 metabolites aberrant levels with...
Abstract Basal progenitor cells are crucial for maintaining foregut (the esophagus and forestomach) homeostasis. When their function is dysregulated, it can promote inflammation tumorigenesis. However, the mechanisms underlying these processes remain largely unclear. Here, we employ genetic mouse models to reveal that Jag1/2 regulate esophageal homeostasis tumorigenesis by modulating of basal cells. Deletion in mice disrupts forestomach epithelial Mechanistically, deficiency impairs...