A5103157934- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Estrogen and related hormone effects
- Cannabis and Cannabinoid Research
- Effects and risks of endocrine disrupting chemicals
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects of Natural Compounds
- Neurotransmitter Receptor Influence on Behavior
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Ginseng Biological Effects and Applications
- Forensic Toxicology and Drug Analysis
- Pain Mechanisms and Treatments
- Natural Antidiabetic Agents Studies
- Exercise and Physiological Responses
- Pancreatitis Pathology and Treatment
- Phytochemicals and Antioxidant Activities
- Stress Responses and Cortisol
- Toxic Organic Pollutants Impact
- Analytical Chemistry and Chromatography
- Phytochemistry and Biological Activities
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
China Pharmaceutical University
2020-2025
Peking Union Medical College Hospital
2025
Affiliated Hospital of Jiangsu University
2025
Jiangsu University
2025
Beijing Anzhen Hospital
2024
Capital Medical University
2024
Nanchong Central Hospital
2017-2024
Xavier University of Louisiana
2006-2023
North Sichuan Medical University
2017-2022
G protein-coupled receptors (GPCRs) are important potential drug targets for the treatment of metabolic disorders. The D2 dopamine receptor (DRD2), a GPCR receptor, is member family. However, role DRD2 in regulating lipid metabolism, especially hepatic steatosis, unclear. Eight-week male mice were fed HFHC/MCD to induce MASH model. AAV2/8 containing TBG promoter was used knock down and overexpress mouse liver. Co-immunoprecipitation, Western lotting, immunofluorescence, immunohistochemistry...
Orally bioavailable SERDs may offer greater systemic drug exposure, improved clinical efficacy, and more durable treatment outcome for patients with ER-positive endocrine-resistant breast cancer. We report the design synthesis of a boronic acid modified fulvestrant (5, ZB716), which binds to ERα competitively (IC50 = 4.1 nM) effectively downregulates in both tamoxifen-sensitive tamoxifen-resistant cancer cells. Furthermore, It has superior oral bioavailability (AUC 2547.1 ng·h/mL) mice,...
Oxidative stress has been recognized as the contributor to diabetic peripheral neuropathy (DPN). Antioxidant strategies have most widely explored; nevertheless, whether antioxidants alone prevent DPN still remains inconclusive. In present study, we established an in vitro cell model for drug screening using Schwann RSC96 cells under high glucose (HG) stimulation, and found that salvianolic acid A (SalA) mitigated HG-induced injury evidenced by viability myelination. Mechanistically, SalA...
Metabolic changes associated with diabetes are reported to lead the onset of early-stage diabetic nephropathy (DN). Furthermore, lipotoxicity is implicated in renal dysfunction. Most studies DN have focused on a single or limited number lipids, and lipidome kidney during remains be elucidated. In present study, we aimed comprehensively identify lipid abnormalities DN; this end, established an rat model by feeding high-sucrose high-fat-diet combined administration low-dose streptozotocin....
Endocrine disrupting compounds (EDCs), represented by steroid hormones, organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and bisphenol A have been determined in four sediment cores from the Gulf of Mexico, New Orleans surface water (Lake Pontchartrain Mississippi River), influent effluent a municipal sewage treatment plant. During five-month monitoring selected EDCs River (MR) Lake (LP) 2008, 21 29 OCPs MR 17 LP were detected; was detected all samples. Steroid hormones...
Advances in oral SERDs development so far have been confined to nonsteroidal molecules such as those containing a cinnamic acid moiety, which are earlystage clinical evaluation. ZB716 was previously reported an orally bioavailable SERD structurally analogous fulvestrant. In this study, we examined the binding details of estrogen receptor alpha (ERα) by computer modeling reveal its interactions with ligand domain steroidal molecule. We also found that modulates ERα-coregulator nearly...
Development of orally bioavailable nonsteroidal selective estrogen receptor downregulators (SERDs) provides clinical opportunities for the long-term treatment and adjuvant therapy breast cancer at all stages. We describe design, synthesis, identification a boron-modified GW7604 derivative (GLL398, 9), SERD candidate, in which boronic acid functional group replaces phenolic hydroxyl GW7604. Compound 9 strongly binds to ERα fluorescence resonance energy transfer binding assay (IC50 = 1.14 nM)...
Abstract With the development of industry, demand for powdered materials has gradually increased. Dust pollution generated during loading and transportation become increasingly severe. Silica powder is widely used in chemical production; however, a large amount dust feeding process silica powder, which can lead to silicosis workers exposed it over long periods. To address issue substantial generation this paper analyzes mechanisms formation forces acting on process. Additionally, using...
Inflammatory bowel disease (IBD) has become a global healthcare issue, with its incidence continuing to rise, but currently there is no complete cure. Xylitol widely used sweetener in various foods and beverages, limited research on the effects of xylitol IBD symptoms. Study effect oral improving intestinal inflammation damage mice, further explore mechanism alleviating symptoms using microbiota non-targeted metabolomics techniques. An mouse model was induced sodium dextran sulfate (DSS)....
Endoplasmic reticulum (ER) stress is known to impair the function of visceral adipose tissue (VAT) and subcutaneous (SAT), disrupting lipid metabolism. Despite crucial role plays in regulating function, specific lipidomic alterations VAT SAT under ER remain unclear. In this study, was induced SAT, targeted transcriptomic approaches were used analyze metabolism gene expression profiles. The results revealed that exhibited a stronger response, characterized by significant increase binding...
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous organic pollutants in urban environments. Incomplete combustion of petroleum and coal the primary sources elevated concentrations PAHs. The purposes study were: 1) to determine compare concentration PAHs soils taken from two major US cities, New Orleans Detroit; 2) examine main by diagnostic PAH ratios. A total 107 soil samples were 6 census tracts (n = 13–19 per tract) compared with 106 Detroit tracts. Sampling sites included house...
This study investigates the dual actions of 6-gingerol in stimulating both plasma adiponectin and muscular receptor signaling naturally ageing rats.Twenty-two-month-old male SD rats were treated with (0.2 mg kg-1 , once daily) for 7 weeks. 6-Gingerol can attenuate age-associated high triglyceride, glucose, insulin concentrations under fasting conditions as well suppress increase HOMA-IR index inhibit decrease p-Akt/Akt protein rats, which indicates an improvement systemic sensitivity....
Once protein synthesis is excessive or misfolded becomes aggregated, which eventually overwhelms the capacity of endoplasmic reticulum (ER), a state named ER stress would be reached. could affect many tissues, especially liver, in nonalcoholic fatty liver disease, steatosis, etc. have been reported relative. However, there still lack systematic insight into can obtained by integrating metabolomics and transcriptomics tissue. Here, tunicamycin was utilized to induce C57BL/6N mice. Microarray...
Niclosamide effectively downregulates androgen receptor variants (AR-Vs) for treating enzalutamide and abiraterone-resistant prostate cancer. However, the poor pharmaceutical properties of niclosamide due to its solubility metabolic instability have limited clinical utility as a systemic treatment A novel series analogs was prepared systematically explore structure–activity relationship identify active AR-Vs inhibitors with improved based on backbone chemical structure niclosamide. Compounds...
Background: White adipose tissue (WAT) browning confers beneficial effects on metabolic diseases. However, visceral (VAT) is not as susceptible to subcutaneous (SAT). Aim: Interpreting the heterogeneity of VAT and SAT in brown remodeling provide promising lipid targets promote WAT browning. Methods: We first investigated β3-adrenergic stimulation by CL316,243 systemic metabolism. Then, high-coverage targeted lipidomics approach with multiple reaction monitoring (MRM) was utilized extensive...
<i>R</i>(+)-[2,3-Dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2, 3-de]1,4-benzoxa zinyl]-(1-naphthalenyl)methanone mesylate (WIN55212-2) is a potent cannabinoid receptor agonist that has been found to exhibit antinociceptive activity and inhibit brain cyclooxygenase. The metabolism of WIN55212-2 not reported, it unknown whether its metabolites retain any properties. In this study, in vitro rat liver microsome was investigated. metabolic profile obtained using high-performance liquid...