A5078073736- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Obstructive Sleep Apnea Research
- Lipid metabolism and biosynthesis
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Urinary Bladder and Prostate Research
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
- Axon Guidance and Neuronal Signaling
- Diabetes Management and Research
- Environmental Impact and Sustainability
- Lipid metabolism and disorders
- Apelin-related biomedical research
- Exercise and Physiological Responses
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pulmonary Hypertension Research and Treatments
- Medical Imaging and Pathology Studies
Hospital Universitario Miguel Servet
2014-2025
Instituto de Investigación Sanitaria Aragón
2020-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2025
University of Illinois Chicago
2016-2023
Universidad Complutense de Madrid
2023
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2023
NorthShore University HealthSystem
2021-2022
University of Chicago
2021-2022
Instituto Aragonés de Ciencias de la Salud
2014
Universidad de Zaragoza
2014
Abstract Autoimmune (AI) diseases can affect many organs; however, the prostate has not been considered to be a primary target of these systemic inflammatory processes. Here, we utilize medical record data, patient samples, and in vivo models evaluate impact inflammation, as seen AI diseases, on tissue. Human mouse tissues are used examine whether targeting inflammation limits prostatic hyperplasia. Evaluation 112,152 records indicates that benign hyperplasia (BPH) prevalence is...
Insulin signaling plays pivotal roles in the development and metabolism of many tissues cell types. A previous study demonstrated that ablation insulin receptor (IR) with aP2-Cre markedly reduced adipose mass protected mice from obesity. However, multiple studies have widespread non-adipocyte recombination floxed alleles mice. These findings underscore need to re-evaluate role IR adipocyte systemic a more tissue-specific Cre mouse line. We generated phenotyped new model using Adipoq-Cre Here...
Background/Objectives: Lung cancer is the primary cause of cancer-related deaths. Most patients are typically diagnosed at advanced stages. Low-dose computed tomography (LDCT) has been proven to reduce lung mortality, but screening programs using LDCT associated with a high number false positives and unnecessary thoracotomies. It therefore imperative that certain diagnosis refined, especially in cases solitary pulmonary nodules difficult technically access for an accurate preoperative...
Obstructive sleep apnea (OSA) is associated with increased risk for cardiovascular morbidity and mortality. Epidemiological animal models studies generate hypotheses innovative strategies in OSA management by interfering intermediates mechanisms complications. We have thus initiated the Epigenetics modification Sleep Apnea (EPIOSA) study (ClinicalTrials.gov identifier: NCT02131610).EPIOSA a prospective cohort aiming to recruit 350 participants of caucasian ethnicity free other chronic or...
Abstract Secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) is a poorly characterized secreted protein largely unknown physiological function. Here we demonstrate that scEMC10 upregulated in people with obesity and positively associated insulin resistance. Consistent causal role for obesity, Emc10 -/- mice are resistant to diet-induced due an increase energy expenditure, while overexpression decreases thus promoting mouse. Furthermore, neutralization circulating...
Through stromal-epithelial interactions, carcinoma associated fibroblasts (CAF) play a critical role in tumor growth and progression. Activation of erythrophoyetin-producing human hepatocellular (Eph) receptors has been implicated cancer. Eph receptor interactions with Ephrin ligands lead to bidirectional signals the recipient effector cells. The consequences continuous reverse signaling activation on prostate cancer (PCa) is unknown. When compared benign fibroblast, CAF displayed higher...
Background Brown adipose tissue (BAT) has a great relevance in metabolic diseases and been shown to be reduced obesity insulin resistance patients. Currently, Dixon MRI is used calculate fat‐water fraction (FWF) differentiate BAT from white (WAT). However, it may fail areas of phase wrapping introduce swapping artifacts. Purpose To investigate the capacity Z‐spectrum imaging (ZSI) for identification vivo. Study Type Retrospective study. Specimens: WAT, BAT, lean healthy mice. Animals: Four...
Background: White adipose tissue (WAT) browning confers beneficial effects on metabolic diseases. However, visceral (VAT) is not as susceptible to subcutaneous (SAT). Aim: Interpreting the heterogeneity of VAT and SAT in brown remodeling provide promising lipid targets promote WAT browning. Methods: We first investigated β3-adrenergic stimulation by CL316,243 systemic metabolism. Then, high-coverage targeted lipidomics approach with multiple reaction monitoring (MRM) was utilized extensive...
Abstract In contrast to white adipose tissue, brown tissue (BAT) is known play critical roles for both basal and inducible energy expenditure. Obesity associated with reduction of BAT function; however, it not well understood how obesity promotes dysfunction, especially at the molecular level. Here we show that transcription regulator TRIP-Br2 mediates ER stress-induced inhibition lipolysis thermogenesis in BAT. Using vitro, ex vivo, vivo approaches, demonstrate obesity-induced inflammation...
Abstract The sensitivity of air quality model responses to modifications in input data (e.g. emissions, meteorology and boundary conditions) or configurations is recognized as an important issue for modelling applications support plans. In the framework FAIRMODE (Forum Air Quality Modelling Europe, https://fairmode.jrc.ec.europa.eu/ ) a dedicated exercise has been designed address this issue. main goal was evaluate magnitude variability when studying emission scenarios/projections by...
Abstract We found the hepatic transcription factor Cyclic-AMP Responsive Element Binding Protein 3-like-3 (CREB3L3) to be expressed in adipose tissue, and selectively downregulated more metabolically protective subcutaneous tissue obese mice humans. sought elucidate specific role of this biology. CREB3L3 fat-specific knockout were fed a high-fat diet induce obesity metabolic dysfunction. Additionally, we injected flip-excision adeno-associated virus directly into inguinal Adiponectin-Cre...
Abstract Long-term ad libitum dietary restrictions, such as low-protein diets (LPDs), improve metabolic health and extend the life span of mice humans. However, most studies conducted thus far have focused on preventive effects LPDs syndromes. To test therapeutic potential LPD, we treated a lipodystrophy mouse model IR FKO (adipose-specific insulin receptor knockout) in this study. We previously shown that profound resistance, hyperglycemia, whitening interscapular brown adipose tissue...
Abstract Benign prostatic hyperplasia (BPH) is ostensibly linked to autoimmune (AI) diseases, but whether the prostate a target of systemic inflammation associated with AI conditions unknown. Prostatic fibrosis, hyperplasia, and reduced responses BPH-related medical therapies. This study was conducted determine if disease correlates BPH diagnosis targeting an inflammatory mediator limits hyperplasia. Patient records (n=112,152) were evaluated prevalence among different diseases. Inflammatory...
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II (MP51)1 Apr 2020MP51-07 LOSS OF EPHRIN SIGNALING ALTERS THE LIPID RHEOSTAT ASSOCIATED WITH PROSTATE CANCER RACIAL DISPARITIES Alejandro Morales, Victoria Gil, Susan Crawford, Simon Hayward, and Omar Franco* MoralesAlejandro Morales More articles by this author , GilVictoria Gil CrawfordSusan Crawford HaywardSimon Hayward Franco*Omar View All Author...
Proteins secreted from metabolic organs play critical roles in fine-tuning and maintenance of systemic energy homeostasis. In this study, we identified a novel obesity-regulated circulating protein, scEmc10 (secreted-isoform endoplasmic reticulum membrane complex subunit 10), that regulates We initially observed is modulated adipose tissues diet-induced obesity (DIO) models subsequently obese patients. Using an in-house-developed chemiluminescent immunoassay, found Emc10 significantly...
Restricted accessAbstractFirst published online March 1, 2016Transcription Factor Creb3L3 is a Novel Regulator for Adipocyte Biology and MetabolismS Duncan, M McCann, […], G Qiang, V Gil, H Whang Kong, C Liew+3-3View all authors affiliationsVolume 64, Issue 4https://doi.org/10.1136/jim-2016-000120.41
<b>Background:</b> CRP is an inflammatory biomarker associated with atherosclerosis and cardiovascular disease (CVD). Obesity important OSA risk factor. To determine the independent roles of obesity in CVD complicated by their coexistence. <b>Aim:</b> assess association levels a clinical cohort otherwise healthy patients specifically to if it depends on body weight. <b>Methods:</b> Data from <i>Epigenetics modifications Obstructive Sleep Apnea (EPIOSA),</i> prospective clinical-based study...
<b>Background:</b> OSA is associated with clinical cardiovascular disease (CVD), but its relation to subclinical atherosclerosis remains controversial. Few studies have examined the association between and carotid intima-media thickness (IMT), a surrogate of atherosclerosis, most which are small case-control samples or comorbidities. <b>Aim:</b> To assess whether patients without CVD, chronic diseases CVD risk factors evaluated by IMT compared controls. <b>Methods</b> As part <i>Epigenetics...