A5077976671- Lipid metabolism and biosynthesis
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Silicon and Solar Cell Technologies
- Particle Detector Development and Performance
- Silicon Carbide Semiconductor Technologies
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Hormonal and reproductive studies
- Menopause: Health Impacts and Treatments
- Vascular Tumors and Angiosarcomas
- Esophageal and GI Pathology
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Soft tissue tumor case studies
- Gastrointestinal disorders and treatments
- Intracranial Aneurysms: Treatment and Complications
- Connective tissue disorders research
- Soft tissue tumors and treatment
- Optical Imaging and Spectroscopy Techniques
- PI3K/AKT/mTOR signaling in cancer
- Intraperitoneal and Appendiceal Malignancies
- Genomic variations and chromosomal abnormalities
- Sphingolipid Metabolism and Signaling
- Ubiquitin and proteasome pathways
Brigham and Women's Hospital
2023
Harvard University
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023
University of Ferrara
2019-2022
NorthShore University HealthSystem
2018-2021
University of Chicago
2018-2021
Istituto Giannina Gaslini
2012-2021
University of Dundee
2014-2015
University of Milan
2000-2001
University of Genoa
1996-1999
After neuronal injury and in several neurodegenerative diseases, activated microglia secrete proinflammatory molecules that can contribute to the progressive neural damage. The recent demonstration of a protective role estrogen disorders humans experimental animal models led us investigate whether this hormone regulates inflammatory response CNS. We here show exerts an anti-inflammatory activity on primary cultures rat microglia, as suggested by blockage phenotypic conversion associated with...
Abstract Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which increased metabolically active cells to meet nutrient requirements. DGAT1 has been recognized as an anti-obesity target; however, its role the tumor microenvironment remains unclear. We postulated that, prostate cancer (PCa) cells, augmented and growth are due expression leading microtubule-organizing center (MTOC) amplification. Thus, therapeutic targeting of potentially suppressive activity....
Despite the success of KRAS G12C inhibitors in non-small cell lung cancer (NSCLC), more effective treatments are needed. One preclinical strategy has been to co-target RAS and mTOR pathways, however toxicity due broad inhibition limited its utility. Therefore, we sought develop a refined means targeting cap-dependent translation identify most therapeutically important eIF4F-translated targets. Here show that an eIF4A inhibitor, which targets component eIF4F, dramatically enhances effects...
Expression and activity of the System A/SNAT2 (SLC38A2) amino acid transporter is up-regulated by starvation hypertonicity a mechanism dependent on both ATF4-mediated transcription SLC38A2 gene enhanced stabilization SNAT2 itself, which forms part an integrated cellular stress response to nutrient deprivation osmotic stress. Here we demonstrate that this adaptive increase in A function restrained cells subjected prior incubation with linoleic (LOA, unsaturated C18:2 fatty acid) for 24 h....
Abstract Despite advances in cancer therapeutics, there remains a critical need to identify new protein targets and targeting approaches for drug development, particularly those with improved efficacy safety profiles. To address these challenges, InduPro leverages high-resolution proximity proteomics technology that uses photocatalyst-generated reactive probes label cell surface microenvironments (1, 2). Combining this quantitative mass spectrometry, we achieve high-throughput...
Aims/Hypothesis Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated (MUFA PUFA) not only improve but blunt SFA-induced resistance. The mechanisms by which MUFAs PUFAs institute these favourable changes remain unclear, may involve stimulating signalling counter-modulation/repression of protein phosphatase 2A (PP2A). This study investigated the effects oleic acid (OA; MUFA), linoleic...
ABSTRACT Prostate tumors make metabolic adaptations to ensure adequate energy and amplify cell cycle regulators, such as centrosomes, sustain their proliferative capacity. It is not known whether cancer-associated fibroblasts (CAFs) undergo re-programming. We postulated that CAFs augment lipid storage centrosomal or non-centrosomal microtubule-organizing centers (MTOCs) through a pigment epithelium-derived factor (PEDF)-dependent lipid–MTOC signaling axis. Primary human normal prostate (NFs)...
We reviewed the radiological findings in 45 morbidly obese patients (weight range 80-129 kg; mean 95.7 kg) after gastric restriction surgery with adjustable silicone banding (ASBG) according to Kuzmak technique. Radiographic studies of stomach were performed before, and at 4 12 months surgery; symptomatic underwent additional when needed. Patients evaluated using both liquid barium a solid opaque meal assess post-operative morphology as well emptying time proximal pouch. 27 had normal...
Infected total tubular esophageal duplication was detected in an 11-year-old boy presenting with chest pain, dysphagia, cough, and fever. Esophagram (supplemental Fig. 1 [esophagram: water-soluble contrast medium showed a double lumen extending approximately 5 cm; arrowheads: lumen, nonlinear arrow: septum, stars: communication between the 2 lumens, main lumen], https://links.lww.com/MPG/A161) computed tomography [chest tomogram; minimum intensity projection on sagittal plane confirmed...
In subacute stroke patients we studied cortical oxygenation changes by near-infrared spectroscopy (NIRS) during a motor task performed with the hemiparetic arm (15 s of reaching and grasping, 45 rest, repeated 6 times). Twenty-three subjects were included at baseline, compared six healthy subjects, restudied after weeks rehabilitation. Motor/premotor in oxyhemoglobin detected NIRS quantified as area under curve (AUC) for total cortex (TOT-AUC) both affected (AFF-AUC) unaffected hemispheres...
Background: Elastic compression therapy (CT) in patients with peripheral artery disease (PAD) and chronic venous insufficiency (CVI) may compromise arterial perfusion. We evaluated the feasibility of a toe-flexion test, which quantifies dynamic foot perfusion by near-infrared spectroscopy (NIRS), for assessment hemodynamic sustainability CT PAD CVI. Patients methods: In this prospective observational study, aged 50-85 combined CVI at CEAP stages II-IV were studied. The ankle-brachial index...
SPICE simulations of ac-coupled single-sided Si microstrip detectors connected to the PreShape 32 read-out chip have been performed in order determine geometrical characteristics (i.e., strip pitch p and width w) which maximize signal-to-noise ratio. All resistive capacitive elements detector determined as a function w/p ratio by considering experimental simulated data available literature. The model authors propose this work takes into account all main noise sources electronics. minimum...