A5052504172- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- COVID-19 and Mental Health
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Neuroscience of respiration and sleep
- Genetics and Neurodevelopmental Disorders
- Cell Adhesion Molecules Research
- Genomic variations and chromosomal abnormalities
- Cerebrospinal fluid and hydrocephalus
- Congenital heart defects research
- Immunodeficiency and Autoimmune Disorders
- RNA regulation and disease
- Healthcare professionals’ stress and burnout
- Spinal Dysraphism and Malformations
- Advanced Neuroimaging Techniques and Applications
- Nosocomial Infections in ICU
- Sleep and related disorders
- Attention Deficit Hyperactivity Disorder
- Prenatal Screening and Diagnostics
- Vascular Malformations Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Cerebral Venous Sinus Thrombosis
- Herpesvirus Infections and Treatments
- Neonatal and Maternal Infections
Istituto Giannina Gaslini
2016-2025
University of Genoa
2018-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Centro Studi GISED
2024
University of Pavia
2024
Ospedale regionale di Lugano
2020
Centre Hospitalier Universitaire de Nice
2020
Moscow Research and Clinical Center for Neuropsychiatry
2018
University of Milan
2013-2015
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014-2015
To compare psychiatric emergencies and self-harm at emergency departments (EDs) 1 year into the pandemic, to early pandemic pre-pandemic, examine changes in characteristics of presentations.This retrospective cohort study expanded on Pandemic-Related Emergency Psychiatric Presentations (PREP-kids) study. Routine record data March April 2019, 2020, 2021 from 62 EDs 25 countries were included. ED presentations made by children adolescents for any mental health reasons analyzed.Altogether,...
The COVID-19 pandemic has changed individuals' lifestyles to a great extent, particularly in Italy. Although many concerns about it have been highlighted, its impact on children and adolescents scarcely examined. purpose of this study was explore behavioral consequences coping strategies related the among families Italy, by focusing developmental ages from caregivers' perspective, 3 weeks into quarantine. An exploratory cross-sectional online survey conducted over 14 days. Google Forms...
Early exposure to nociceptive events may cause brain structural alterations in preterm neonates, with long-lasting consequences on neurodevelopmental outcome. Little is known the extent which early pain affect connectivity. We aim evaluate functional connectivity changes neonate that underwent multiple invasive procedures during postnatal period, and correlate them outcome at 24 months.In this prospective case-control study, we collected information about painful period resting-state...
Besides recent advances in neonatal care, preterm newborns still develop sex-biased behavioral alterations. Preterms fail to receive placental insulin-like growth factor-1 (IGF-1), a major fetal hormone utero, and low IGF-1 serum levels correlate with poor neurodevelopmental outcomes. Here, we mimicked deficiency of mice by perinatal administration an receptor antagonist. This resulted brain microstructural, functional, alterations, resembling those ex-preterm children, which characterized...
Importance There are suggestions that school pressure may be stressful and a factor in child adolescent mental health disturbances, but data about this association scarce inconclusive. Objective To assess whether varying degrees of interruption were associated with changes emergency department (ED) psychiatric visits children adolescents before after the COVID-19 outbreak. Design, Setting, Participants A cross-sectional observational study was conducted at 9 urban university hospitals Italy....
Objectives: Whether PANS (pediatric acute-onset neuropsychiatric syndrome) and PANDAS autoimmune disorders associated with streptococcal infection) represent true clinical entities is debated data for a characteristic phenotype are still controversial. In this study, we aim to characterize clinical, neuropsychological, biochemical aspects in sample of patients. Methods: Patients fulfilling diagnosis or from 2014 2017 were enrolled. Neurological psychiatric examination instrumental assessment...
To determine whether isolated low-grade germinal matrix-intraventricular haemorrhages (LG-GMH-IVH) and punctate cerebellar (LG-CBH) contribute to the neurodevelopment of infants born preterm with very low birthweight (VLBW).A prospective observational cohort study was conducted on VLBW hospitalized from January 2012 July 2017 who had undergone serial cranial ultrasounds since birth magnetic resonance susceptibility-weighted imaging brain at term-corrected age. Only those carrying LG-GMH-IVH...
Preterm birth is associated with numerous neurodevelopmental adverse outcomes, even in the absence of acquired lesions, as it occurs during a critical period brain development. Clear organization vigilance states can be recognized from 30–32 weeks postmenstrual age (PMA). In this study, we investigated whether spatial and temporal properties neuronal oscillatory dynamics (i.e., phase synchronization, bistability, cross-frequency coupling) different provide insights into cortical maturation...
<b>Objective</b> This study aims to describe the impact of twin birth, chorionicity, intertwin birth weight (BW) discordance and order on neonatal outcomes. <b>Study Design</b> We performed a hospital-based retrospective 2,170 twins (6.4% all live births) 2,217 singletons inborn 2007 2011. Data characteristics, morbidities, mortality were collected compared. Univariate multiple (adjusted for gestational age [GA] gender) linear random intercept regression models used. <b>Results</b> Overall,...
During the last decades, severe brain lesions affecting very low birth weight (<1500 gr, VLBW) infants were gradually substituted by milder with debatable prognoses.The objective of this study is to define type, frequency and 3 years neurodevelopmental outcome prematurity-related in a modern cohort VLBW infants.VLBW admitted our NICU 5 period MRI at term-equivalent age included. scans reviewed identify grade white matter (WML), intraventricular hemorrhage (IVH), cerebellar (CBH). Linear...
Extra-uterine growth restriction (EUGR) is a common complication and known risk factor for impaired development in very-low-birth-weight (VLBW) neonates. We report population of 288 patients with no or low-grade MRI lesions scanned at term equivalent age (TEA) born between 2012 2018. Griffiths Mental Development Scale II (GMDS II) 2 3 years, preterm complications weight were retrospectively analyzed. EUGR was defined z-score ˂ 10 percentile TEA, 6 12 months correct as decreased by 1-point...
<h3>Background</h3> Fibrodysplasia ossificans progressiva is an autosomal dominant disorder due to germline mutations of <i>ACVR1/ALK2</i> causing progressive heterotopic endochondral ossifications. Evidence central nervous system involvement has emerged only recently. <h3>Methods</h3> We performed observational cross-sectional brain MRI study in 13 patients (8 females, mean age 20 years), examining the relationship clinical and neuroradiological findings. <h3>Results</h3> All presented...
<h3>BACKGROUND AND PURPOSE:</h3> Segmental callosal agenesis is characterized by the absence of intermediate portion. We aimed to evaluate structural connectivity segmental using constrained spherical deconvolution tractography and connectome analysis. <h3>MATERIALS METHODS:</h3> reviewed clinical-radiologic features 8 patients (5 males; mean age, 3.9 years). Spherical probabilistic were performed on diffusion data. Structural analysis, including summary network metrics, modularity...
Submicroscopic chromosomal alterations usually involve different protein-coding genes and regulatory elements that are responsible for rare contiguous gene disorders, which complicate the understanding of genotype-phenotype correlations. Chromosome band 3p26.3 contains 3 encoding neuronal cell adhesion molecules: <i>CHL1</i>, <i>CNTN6</i>, <i>CNTN4</i>. We describe 2 boys aged 8 years 11 mainly affected by intellectual disability autism spectrum disorder,...