A5016731198- Schizophrenia research and treatment
- Diet and metabolism studies
- Fatty Acid Research and Health
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Child Nutrition and Feeding Issues
- Alcoholism and Thiamine Deficiency
- Attention Deficit Hyperactivity Disorder
- Advanced MRI Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Mental Health Treatment and Access
- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Suicide and Self-Harm Studies
- Treatment of Major Depression
- Diet, Metabolism, and Disease
- Neurotransmitter Receptor Influence on Behavior
- Neural and Behavioral Psychology Studies
- Psychiatric care and mental health services
University of Zurich
2016-2025
University Hospital of Zurich
2016-2025
The University of Melbourne
2006-2024
Orygen
2003-2024
Institute for Social-Ecological Research
2023
The University of Sydney
2021
Montanuniversität Leoben
2020
Universitätsklinik für Kinder und Jugendpsychiatrie
2014-2020
Bellingham Technical College
2020
Universitäre Psychiatrische Dienste Bern
2018
<h3>Context</h3> The use of antipsychotic medication for the prevention psychotic disorders is controversial. Long-chain ω-3 (omega-3) polyunsaturated fatty acids (PUFAs) may be beneficial in a range psychiatric conditions, including schizophrenia. Given that PUFAs are generally to health and without clinically relevant adverse effects, their preventive psychosis merits investigation. <h3>Objective</h3> To determine whether reduce rate progression first-episode disorder adolescents young...
There is growing interest in the prodromal stage of psychotic disorders, with many services now providing care for these "ultra high risk" (UHR) individuals. However, a reduction rate transition to psychosis has been suspected over last few years. This implications use interventions this population and validity research findings. study examined one UHR service, Personal Assessment Crisis Evaluation Clinic, years 1995–2000 investigated possible causes reduction. was evidence declining rate,...
A promising treatment to prevent onset and improve outcomes in patients at ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated fatty acids (PUFAs).To determine whether PUFAs combination a high-quality psychosocial intervention (cognitive behavioral case management [CBCM]) more effective than placebo plus CBCM.NEURAPRO, double-blind, placebo-controlled, randomized clinical trial, was conducted from March 1, 2010, September 30, 2014, 10 specialized early...
Neuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timing their emergence and extent to which they related vulnerability disorder as opposed psychotic illness itself is unclear.To assess regional grey matter volume in at-risk individuals who subsequently developed psychosis.Magnetic resonance imaging data from psychosis (n=12) within following 25 months were compared with healthy volunteers (n=22) people first-episode (n=25).Compared volunteers, had...
Cognitive therapy and/or low-dose antipsychotic administered during the prodromal phase of schizophrenia may prevent or delay onset full-blown illness. However, it is unclear which these treatments are most effective, how long treatment should be given, and whether effects will sustained over a prolonged period.In order to examine issues, we conducted randomized controlled trial cognitive + risperidone; placebo; supportive placebo in young people at ultra high risk for developing psychotic...
Article Abstract Objective: The ultra-high risk clinical phenotype is associated with substantial distress and functional impairment confers a greatly enhanced for transition to full-threshold psychosis. A range of interventions aimed at relieving current symptoms reducing the psychosis has shown promising results, but optimal type sequence intervention remain be established. aim this study was determine which most effective preventing psychosis: cognitive therapy plus low-dose risperidone,...
To compare psychiatric emergencies and self-harm at emergency departments (EDs) 1 year into the pandemic, to early pandemic pre-pandemic, examine changes in characteristics of presentations.This retrospective cohort study expanded on Pandemic-Related Emergency Psychiatric Presentations (PREP-kids) study. Routine record data March April 2019, 2020, 2021 from 62 EDs 25 countries were included. ED presentations made by children adolescents for any mental health reasons analyzed.Altogether,...
Article AbstractObjective: To investigate if ethyl-eicosapentaenoic acid (E-EPA) augmentation improves antipsychotic efficacy and tolerability in first-episode psychosis (FEP). Method: We performed a 12-week, randomized, double-blind, placebo-controlled trial of 2-g E-EPA 80 FEP patients. Sixty-nine patients were eligible for analysis; post hoc analysis was computed subgroup nonaffective (N = 53). The first participant included November 2000 the last completed August 2003. Primary outcome...
Intervention in the prodromal phase of schizophrenia and related psychotic disorders may prevent or delay onset these disorders, reduce severity psychosis. Identifying prodrome is difficult, however, because its non-specific symptoms wide symptom variability between individuals. Over past 15 years, we have investigated developed criteria for detecting people suspected experiencing a (ie, they are thought to be at imminent risk disorder). About 35% those meeting our disorder within 12 months....
Epidemiological evidence from population-based surveys suggest that the psychological well-being of adolescents has been severely affected by COVID-19 pandemic itself, as well safety measures implemented. The rationale study was to investigate influence on psychiatric emergency service use, admissions rates, emotional well-being, suicidality and self-harm behaviour in help-seeking children adolescents.Retrospective cohort electronic patient records before during out-patient facility...
Adolescent major depressive disorder (MDD) is associated with altered resting-state connectivity between the default mode network (DMN) and salience (SN), which are involved in self-referential processing detecting filtering salient stimuli, respectively. Using spectral dynamical causal modelling, we investigated effective input sensitivity key nodes of these networks 30 adolescents MDD 32 healthy controls while undergoing fMRI. We found that DMN received weaker inhibition from SN medial...
The underlying neurobiology of emerging psychotic disorders is not well understood.Recent neuroimaging findings have suggested that some brain areas are affected prior to the onset psychosis, while changes occur in other regions during transition illness.Further, previous research using magnetic resonance spectroscopy (MRS) has generally demonstrated there chemistry patients with schizophrenia.However, it unclear whether these present or at disorder, and what extent they specific...