A5029318499- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Advanced NMR Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Metabolism and Genetic Disorders
- NMR spectroscopy and applications
- Diabetes and associated disorders
- Advanced Neuroimaging Techniques and Applications
- Pancreatic function and diabetes
- RNA modifications and cancer
- Diabetes Management and Research
- Muscle metabolism and nutrition
- Renal function and acid-base balance
- Neurotransmitter Receptor Influence on Behavior
- Ion Transport and Channel Regulation
- Silicone and Siloxane Chemistry
- Neurobiology of Language and Bilingualism
- Metabolomics and Mass Spectrometry Studies
- Food Drying and Modeling
- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- Mitochondrial Function and Pathology
Queensland University of Technology
2011-2020
MIT University
2020
RMIT University
2020
Victoria School of Management
2020
Heidelberg Repatriation Hospital
1993-2012
Florey Institute of Neuroscience and Mental Health
2011
Austin Health
2004-2009
The University of Melbourne
1986-2009
University of Cambridge
2009
Mental Health Research Institute
2007-2008
To investigate the impact of new-onset diabetic ketoacidosis (DKA) during childhood on brain morphology and function.Patients aged 6-18 years with without DKA at diagnosis were studied four time points: <48 h, 5 days, 28 6 months postdiagnosis. Patients underwent magnetic resonance imaging (MRI) spectroscopy cognitive assessment each point. Relationships between clinical characteristics presentation MRI neurologic outcomes examined using multiple linear regression, repeated-measures, ANCOVA...
SCN1B, the gene encoding sodium channel beta 1 subunit, was first identified for generalized epilepsy with febrile seizures plus (GEFS+). Only three families have been published SCN1B mutations. Here, we present four new mutations and characterize associated phenotypes. Analysis of performed on 402 individuals various syndromes. Four probands missense were identified. Detailed electroclinical phenotyping all available affected family members including quantitative MR imaging in those...
Context:The medial frontal cortex (MFC), including the dorsal anterior cingulate and supplementary motor area, is critical for adaptive inhibitory control of behavior.Abnormally high MFC activity has been a consistent finding in functional neuroimaging studies obsessive-compulsive disorder (OCD).However, precise regions neural alterations associated with this abnormality remain unclear.Objective: To examine biochemical properties patients OCD.Design: Cross-sectional study combining...
OBJECTIVE—In this study, we used neurocognitive assessment and neuroimaging to examine brain function in youth with type 1 diabetes studied prospectively from diagnosis. RESEARCH DESIGN AND METHODS—We diabetic (n = 106) control subjects 75) no significant group difference on IQ at baseline 12 years previously by using the Wechsler Abbreviated Scale of General Intelligence, magnetic resonance spectroscopy imaging, metabolic data RESULTS—Type had lower verbal full scale IQs than (both P...
Articular cartilage from a material science point of view is soft network composite that plays critical role in load-bearing joints during dynamic loading. Its structure, consisting collagen fiber and hydrated proteoglycan matrix, gives rise to the complex mechanical properties tissue including viscoelasticity stress relaxation. Melt electrospinning writing allows design fabrication medical grade polycaprolactone (mPCL) fibrous networks for reinforcement hydrogel matrices engineering....
Here we report a class of photocatalysts: mixed-valence vanadium oxide particles grafted onto variety supports. In these catalysts V6O13 species with mixed oxidation states (V4+ or V5+) are believed to be catalytically active sites. These successfully enable alcohol selectively produce aldehydes and ketones using O2 as the oxidant. The catalytic process is driven by visible light irradiation at room temperature and, most importantly, progresses negligible overoxidation. can even oxidize...
<b><i>Objective:</i></b> To describe a protocol for use in young children and adolescents determining language representation. <b><i>Methods:</i></b> We performed 130 fMRI studies 48 17 adults. Verb generation (VG) orthographic lexical retrieval (OLR) were used. The localization lateralization of activation was rated visually. Regional voxel counts measured asymmetry extent activation. <b><i>Results:</i></b> Activation predominantly left-lateralized (children 85%, adults 94%), there no...
Objective: Abnormalities of the anterior cingulate cortex (ACC) have consistently been identified in obsessive–compulsive disorder (OCD), but very few studies examined biochemical basis such changes. The purpose present study was to investigate how ACC biochemistry OCD varies as a function gender, hemisphere, subregion, and symptomatology. Method: 3 T proton-magnetic resonance spectroscopy (MRS) used probe 20 patients (10 male, 10 female) comparable group 26 healthy comparison subjects. Data...
To determine whether cerebral metabolite changes may underlie abnormalities of neurocognitive function and respiratory control in OSA.Observational, before after CPAP treatment.Two tertiary hospital research institutes.30 untreated severe OSA patients, 25 age-matched healthy controls, all males free comorbidities, having had detailed structural brain analysis using voxel-based morphometry (VBM).Single voxel bilateral hippocampal brainstem, multivoxel frontal concentrations were measured...
Biological tissues are viscoelastic, demonstrating a mixture of fluid and solid responses to mechanical strain. Whilst viscoelasticity is critical for native tissue function, it rarely used as design criterion in biomaterials science or engineering. We propose that may be tailored specific levels through manipulation the hydrogel type, more specifically proportion physical chemical crosslinks present construct. This theory was assessed by comparing properties various blends, comprising...
Lateralization of language function is crucial to the planning surgery in children with frontal or temporal lobe lesions. We examined utility functional magnetic resonance imaging (fMRI) as a determinant lateralization expressive cerebral lesions.fMRI was attempted 35 (29 epilepsy) aged 8-18 years lesions (28 left hemisphere, five right two bilateral). Axial and coronal fMRI scans through lobes were acquired at 1.5 Tesla by using block-design, covert word-generation paradigm. Activation maps...
Objectives: To investigate if low-dose lithium may counteract the microstructural and metabolic brain changes proposed to occur in individuals at ultra-high risk (UHR) for psychosis. Methods: Hippocampal T2 relaxation time (HT2RT) proton magnetic resonance spectroscopy (1H-MRS) measurements were performed prior initiation following three months of treatment 11 UHR patients receiving 10 as usual (TAU). HT2RT 1H-MRS percentage change scores between scans compared using repeated measures ANOVA...
Summary: Objective: We performed spike triggered functional MRI (fMRI) in a 12 year old girl with Benign Epilepsy Centro‐temporal Spikes (BECTS) and left‐sided spikes. Our aim was to demonstrate the cerebral origin of her interictal Methods: EEG recorded within 3 Tesla MRI. Whole brain fMRI images were acquired, beginning 2–3 seconds after Baseline acquired when there no spikes for 20 seconds. Image sets compared Student's t ‐test. Results: Ten baseline volumes analysed. Focal activiation...