A5072967810- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Proteoglycans and glycosaminoglycans research
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Total Knee Arthroplasty Outcomes
- Cell Adhesion Molecules Research
- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Musculoskeletal Disorders and Rehabilitation
- Advanced Sensor and Energy Harvesting Materials
- Bone health and treatments
- Collagen: Extraction and Characterization
- Pregnancy and Medication Impact
- Inflammatory mediators and NSAID effects
- Reproductive System and Pregnancy
- Lower Extremity Biomechanics and Pathologies
- Extracellular vesicles in disease
- Nasal Surgery and Airway Studies
Queensland University of Technology
2016-2025
Australian Research Council
2017-2022
Kelvin Nanotechnology (United Kingdom)
2019
Brisbane School of Theology
2019
Girls Incorporated
2008
University of California, San Diego
2003-2007
La Jolla Bioengineering Institute
2003-2007
Polytechnique Montréal
2007
Harvey Mudd College
1997
Abstract Gelatin‐methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation give wide ranging mechanical properties depending on several cross‐linking parameters. Polymer concentration, UV exposure time, thermal gelation prior allow for control over hydrogel stiffness swelling properties. GelMA solutions have a low viscosity at 37 °C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or...
As direct effector cells for osteogenesis, osteoblastic are commonly used evaluating the in vitro osteogenic capacity of bone biomaterials, and traditional biological principle developing biomaterials is to directly stimulate differentiation. With this principle, most efforts currently spent on optimizing bio-mechanical physicochemical properties induce differentiation mesenchymal stem cells. This strategy has achieved certain success development biomaterials; however, inconsistencies...
Abstract Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction native cellular organization. Here, it reported that ultrasound standing waves can be used to organize myoblast populations in material systems aligned muscle tissue constructs. Patterned engineered using type I collagen hydrogels exhibits significant anisotropy tensile strength, under mechanical...
Articular cartilage from a material science point of view is soft network composite that plays critical role in load-bearing joints during dynamic loading. Its structure, consisting collagen fiber and hydrated proteoglycan matrix, gives rise to the complex mechanical properties tissue including viscoelasticity stress relaxation. Melt electrospinning writing allows design fabrication medical grade polycaprolactone (mPCL) fibrous networks for reinforcement hydrogel matrices engineering....
Articular cartilage is a highly hydrated tissue with depth-dependent cellular and matrix properties that provide low-friction load bearing in joints. However, the structure function are frequently lost there insufficient repair response to regenerate high-quality cartilage. Several hydrogel-based tissue-engineering strategies have recently been developed form constructs biomimetic zonal variations improve repair. Modular hydrogel systems allow for systematic control over properties, advanced...
There is a need for materials that are well suited cartilage tissue engineering. Hydrogels have emerged as promising biomaterials repair, since, like cartilage, they high water content, and allow cells to be encapsulated within the material in genuinely three-dimensional microenvironment. In this study, we investigated mechanical properties of tissue-engineered constructs using vitro culture models incorporating human chondrocytes from osteoarthritis patients. We evaluated hydrogels formed...
This work investigates neocartilage formation in bovine and porcine gelatin methacryloyl-based hydrogels photocrosslinked using ultraviolet or visible light photoinitiator systems.
Abstract The ex vivo engineering of autologous cartilage tissues has the potential to revolutionize clinical management joint disorders. Yet, high manufacturing costs and variable outcomes associated with tissue-engineered implants are still limiting their application. To improve facilitate a wider use engineered tissues, automated bioreactor systems capable enhancing monitoring neotissues required. Here, we developed an innovative system applying precise uni- or biaxial mechanical...
Three-dimensional (3D) bioprinting techniques can be used for the fabrication of personalized, regenerative constructs tissue repair. The current article provides insight into potential and opportunities 3D cartilage constructs. Although printing is already in orthopedic clinic, shift toward has not yet occurred. We believe that this will provide an important step forward field regeneration. allow incorporation cells biological cues during manufacturing process, to generate biologically...
Articular cartilage is comprised of zones that vary in architecture, extracellular matrix composition, and mechanical properties. Here, we designed engineered a porous zonal microstructured scaffold from single biocompatible polymer (poly [ϵ-caprolactone]) using multiple fabrication strategies: electrospinning, spherical porogen leaching, directional freezing, melt electrowriting. With this approach mimicked the structure articular produced stiffness gradient through which aligns with...
Abstract The field of melt electrowriting (MEW) has seen significant progress, bringing innovative advancements to the fabrication biomaterial scaffolds, and creating new possibilities for applications in tissue engineering beyond. Multidisciplinary collaboration across materials science, computational modeling, AI, bioprinting, microfluidics, dynamic culture systems offers promising opportunities gain deeper insights into complex biological systems. As focus shifts towards personalized...
Extrusion-based bioprinting has gained widespread popularity in biofabrication due to its ability assemble cells and biomaterials precise patterns form tissue-like constructs. To achieve this, bioinks must have rheological properties suitable for printing while maintaining cytocompatibility. However, many commonly used do not meet the requirements therefore require modification applications. This study demonstrates incorporation of Laponite-RD (LPN) into gelatin methacryloyl (GelMA) produce...