A5059421804- 3D Printing in Biomedical Research
- Hemoglobin structure and function
- Electrospun Nanofibers in Biomedical Applications
- Protein Structure and Dynamics
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Additive Manufacturing and 3D Printing Technologies
- Lipid Membrane Structure and Behavior
- Enzyme Catalysis and Immobilization
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Materials and Mechanics
- Nanoparticle-Based Drug Delivery
- Bacteriophages and microbial interactions
- Proteins in Food Systems
- RNA Interference and Gene Delivery
- Hydrogels: synthesis, properties, applications
- Pickering emulsions and particle stabilization
- Supramolecular Self-Assembly in Materials
- biodegradable polymer synthesis and properties
- Advanced Sensor and Energy Harvesting Materials
- Enzyme Structure and Function
- Protein purification and stability
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Bio-sensing Technologies
University of Bristol
2016-2025
Australian National University
2005-2025
Macalester College
2023
At Bristol
2016
Charles Clifford Dental Hospital
1978
Abstract Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction native cellular organization. Here, it reported that ultrasound standing waves can be used to organize myoblast populations in material systems aligned muscle tissue constructs. Patterned engineered using type I collagen hydrogels exhibits significant anisotropy tensile strength, under mechanical...
Bioprinting is an emerging technique for the fabrication of living tissues that allows cells to be arranged in predetermined three-dimensional (3D) architectures. However, date, there are limited examples bioprinted constructs containing multiple cell types patterned at high-resolution. Here we present a low-cost process employs 3D printing aqueous droplets mammalian produce robust, oil, which were reproducibly transferred culture medium. Human embryonic kidney (HEK) and ovine mesenchymal...
3D tissue printing with adult stem cells is reported. A novel cell-containing multicomponent bioink used in a two-step process to engineer bone and cartilage architectures.
Injectable biomimetic hydrogels have great potential for use in regenerative medicine as cellular delivery vectors. However, they can suffer from issues relating to hypoxia, including poor cell survival, differentiation, and functional integration owing the lack of an established vascular network. Here we engineer a hybrid myoglobin:peptide hydrogel that concomitantly deliver stem cells oxygen brain support engraftment until vascularisation occur naturally. We show this modulate fate...
Molten proteins: Warming a freeze-dried powder of stoichiometric ferritin–polymer ionic construct produces solvent-free liquid protein that exhibits viscoelastic and thermotropic liquid-crystalline properties at 30 °C (see polarized-light micrograph), transforms into Newtonian fluid above 40 °C.
A protocol for the preparation of stable suspensions well-defined metallized tobacco mosaic virus (TMV) nanorods in high yields and with uniform coatings is reported. Inorganic growth on virion surface was controlled by adding aliquots gold precursor (HAuCl4) reducing agent (NaBH4) incrementally over five addition–reduction cycles to produce hybrid anisotropic nanostructures consisting densely packed nanoparticles. Several novel steps, including addition ethanol after first cycle wrapping...
Using a range of physical methods, we describe the formation, structure, stability, properties and uptake behavior condensed liquid micro-droplets prepared by electrostatically induced complexation poly(diallyldimethylammonium) chloride (PDDA) adenosine triphosphate (ATP) in water. Depending on PDDA monomer: ATP molar ratio, positively charged or charge-neutral droplets are produced spontaneously simple mixing. The former typically 60–600 nm mean size stable with respect to sedimentation up...
Restricted oxygen diffusion can result in central cell necrosis engineered tissue, a problem that is exacerbated when engineering large tissue constructs for clinical application. Here we show pre-treating human mesenchymal stem cells (hMSCs) with synthetic membrane-active myoglobin-polymer-surfactant complexes provide reservoir of capable alleviating at the centre hyaline cartilage. This achieved through development new functionalization methodology based on polymer-surfactant conjugation,...
The 19-mer synthetic peptide known as R5 has been used widely in studies of peptide-driven silica condensation. Despite this, the structure and function have not yet fully characterized. Here, we present a systematic study silicification focusing on three key variables: concentration peptide, precursor silicic acid, solution pH. Additionally, first secondary presence absence acid introduce one-dimensional two-dimensional NMR to probe both higher-order aggregation. We find that R5-directed is...
DNA chains and their movement in solvent may now be controlled simply by surfactant binding the switching "on" "off" of a magnetic field adding new paradigm to study control, condensation manipulation (and other biomolecules). Such control is essential for biotechnological applications such as transfection regulation gene suppression, well materials science concerning soft molecular self-assemblies. Detailed facts importance specialist readers are published "Supporting Information"....
The spontaneous phase separation of peptide/nucleotide droplets in water produces membrane-free chemically organized micro-compartments that offer new opportunities for the construction synthetic cells and development protocell models prebiotic organization. Certain small molecules can be sequestered into droplet interior but uptake mechanisms are unexplored. Using confocal fluorescence microscopy, 31P NMR spectroscopy, spectroscopy lateral molecular force we probe interactions associated...