A5086435562- Viral Infections and Vectors
- Marine animal studies overview
- Veterinary Oncology Research
- Aquaculture disease management and microbiota
- Osteoarthritis Treatment and Mechanisms
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Bird parasitology and diseases
- Amphibian and Reptile Biology
- Microbial infections and disease research
- Toxoplasma gondii Research Studies
- Bartonella species infections research
- Rabies epidemiology and control
- Yersinia bacterium, plague, ectoparasites research
- Animal Virus Infections Studies
- Sarcoma Diagnosis and Treatment
- Virus-based gene therapy research
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Infectious Diseases and Mycology
- Bone Tumor Diagnosis and Treatments
- Mycobacterium research and diagnosis
- Vector-Borne Animal Diseases
- Salmonella and Campylobacter epidemiology
- Coccidia and coccidiosis research
Utrecht University
2015-2024
Tokai University
2023
Erasmus MC
2022-2023
Wageningen University & Research
2020-2023
Dutch Centre for Field Ornithology
2022
Dialyse Centrum Groningen
2022
Erasmus University Rotterdam
2022
Bureau Waardenburg (Netherlands)
2022
Research Institute for Nature and Forest
2022
Stichting tot Steun VCVGZ
2022
Wild carnivore species infected with highly pathogenic avian influenza (HPAI) virus subtype H5N1 during the 2021-2022 outbreak in Netherlands included red fox (Vulpes vulpes), polecat (Mustela putorius), otter (Lutra lutra), and badger (Meles meles). Most of animals were submitted for testing because they showed neurological signs. In this study, HPAI was detected by PCR and/or immunohistochemistry 11 primarily present brain tissue, often associated a (meningo) encephalitis cerebrum....
Histologic grade is an important determinant in clinical outcome of human osteosarcoma (OS). In this study, the histologic characteristics primary and metastatic canine OS were evaluated using a new classification system. classified 166 34 OS. Prognostic variables for determined multivariate analysis. Most histologically characterized by severe to extreme cellular pleomorphism, variable number mitoses, small moderate amounts matrix, high percentage tumor cells, minimal necrosis. Tumor...
In the summer of 2016, Belgium, France, Germany and Netherlands reported widespread Usutu virus (USUV) activity based on live dead bird surveillance. The causative USUV strains represented four lineages, which two putative novel lineages were most likely recently introduced into spread to other western European countries. spatial extent outbreak area corresponded with R 0 values > 1. occurrence outbreak, largest epizootic registered so far in Europe, allowed us gain insight how a...
Mammalian articular cartilage serves diverse functions, including shock absorption, force transmission and enabling low-friction joint motion. These challenging requirements are met by the tissue's thickness combined with its highly specific extracellular matrix, consisting of a glycosaminoglycan-interspersed collagen fiber network that provides unique combination resilience high compressive shear resistance. It is unknown how this critical tissue deals challenges posed increases in body...
We detected infection with highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b in 2 red fox (Vulpes vulpes) cubs found the wild neurologic signs Netherlands. The is related to viruses birds same area.
Abstract We collected data on mass mortality in Sandwich terns (Thalasseus sandvicensis) during the 2022 breeding season Netherlands. Mortality was associated with at least 2 variants of highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b. report carcass removal efforts relative to survival colonies. Mitigation strategies urgently require structured research.
Hepatozoon spp. are tick-borne parasites causing subclinical to clinical disease in wild and domestic animals. Aim of this study was determine prevalence species distribution among mammals ticks Europe.
Arenaviruses are bi-segmented negative-stranded RNA viruses, which were until recently only detected in rodents and humans. Now highly divergent arenaviruses have been identified boid snakes with inclusion body disease (IBD). Here, we describe the identification of a new species variants arenaviruses, tissues captive IBD The Netherlands by next-generation sequencing. Phylogenetic analysis complete sequence open reading frames four predicted proteins one viruses revealed that this virus was...
In the Netherlands, fire salamander ( Salamandra salamandra ) is at edge of its geographic range and restricted to three small populations in extreme south country. Despite species being listed as ‘Endangered’ on national Red List, situation was considered be stable. However, from 2008 onwards dead individuals were seen more than one occasion. A sharp decline numbers has been observed since 2010 (96%; ), but we unable attribute this any known cause amphibian decline, such chytridiomycosis,...
Abstract Usutu virus (USUV) is a mosquito-borne flavivirus circulating in Western Europe that causes die-offs of mainly common blackbirds ( Turdus merula ). In the Netherlands, USUV was first detected 2016, when it identified as likely cause an outbreak birds. this study, dead were collected, screened for presence and submitted to Nanopore-based sequencing. Genomic sequences 112 obtained phylogenetic analysis showed most viruses belonged Africa 3 lineage, molecular clock evaluated their...
Objective— To investigate mutations of the TP53 gene in canine osteosarcoma (OS). Study Design— Clinical historic cohort study. Animals— Client‐owned dogs. Methods— OS (n=59) were screened for complete using polymerase chain reaction and mutation was analyzed by single‐strand conformational polymorphism. outcome dogs with TP53‐mutated compared without a after surgical excision primary tumor. Results— observed 24 59 (40.7%) OS; 3 mutated had 2 mutations. The alterations consisted mainly point...
Campylobacter, Arcobacter, and Helicobacter species have been isolated from many vertebrate hosts, including birds, mammals, reptiles. Multiple studies focused on the prevalence of these Epsilonproteobacteria genera in avian mammalian species. However, little focus has given to presence within reptiles, their potential zoonotic pathogenic roles. In this study, occurrence, diversity, host association intestinal were determined for a large variety From 2011 2013, 444 cloacal swabs fecal...
Abstract Toll-like receptors (TLR) are ancient innate immune crucial for homeostasis and protection against infection. TLRs present in mammals, birds, amphibians fish but have not been functionally characterized reptiles despite the central position of this animal class vertebrate evolution. Here we report cloning, characterization function TLR5 reptile Anolis carolinensis (Green Anole lizard). The receptor (acTLR5) displays typical TLR protein architecture with 22 extracellular leucine rich...
Objective— To investigate the histologic characteristics of feline osteosarcoma (OS) and compare data with phenotypically comparable canine OS. The effects clinical variables on survival statistics were evaluated. Study Design— Retrospective study. Animals— Cats (n=62) dogs (22). Methods— Medical records 62 cats OS reviewed for clinically relevant data. Clinical outcome was obtained by telephone interview. Histologic classified using a standardized grading system. in 22 skeletal compared...
Major hallmarks of osteoarthritis (OA) are cartilage degeneration, inflammation and osteophyte formation. COX-2 inhibitors counteract inflammation-related pain, but their prolonged oral use entails the risk for side effects. Local administration in biocompatible degradable drug delivery biomaterials could offer an efficient safe treatment long-term management OA symptoms. Therefore, we evaluated disease-modifying effects optimal dose polyesteramide microspheres delivering inhibitor celecoxib...
In the four years following first detection of ranavirus (genus Ranavirus, family Iridoviridae) infection in Dutch wildlife 2010, amphibian mortality events were investigated nationwide to detect, characterize and map ranaviruses amphibians over time, establish affected host species clinico-pathological presentation disease these hosts. The ultimate goal was obtain more insight into emergence ecological risk. total 155 dead from 52 sites submitted between 2011 2014, examined using...
Human babesiosis in Europe has been attributed to infection with Babesia divergens and, a lesser extent, venatorum and microti, which are all transmitted humans through bite of Ixodes ricinus. These species circulate the Netherlands, but autochthonous human cases have not reported so far. To gain more insight into natural sources these species, their presence reservoir hosts I. ricinus was examined. Moreover, part ticks were tested for co-infections other tick borne pathogens. In...
The Usutu virus (USUV) is a mosquito-borne zoonotic flavivirus. Despite its continuous circulation in Europe, knowledge on the pathology, cellular and tissue tropism pathogenetic potential of different circulating viral lineages still fragmentary. Here, macroscopic microscopic evaluations are performed association with study cell comparison lesion severity two (Europe 3; Africa 3) 160 Eurasian blackbirds (Turdus merula) Netherlands. Results confirm hepatosplenomegaly, coagulative necrosis...