A5037179989- Vector-borne infectious diseases
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Mosquito-borne diseases and control
- Zoonotic diseases and public health
- Insect symbiosis and bacterial influences
- Yersinia bacterium, plague, ectoparasites research
- Lipid Membrane Structure and Behavior
- Animal Ecology and Behavior Studies
- Parasitic Infections and Diagnostics
- Bartonella species infections research
- Dermatological diseases and infestations
- Animal Disease Management and Epidemiology
- Cellular transport and secretion
- Sphingolipid Metabolism and Signaling
- Amoebic Infections and Treatments
- Parasites and Host Interactions
- Lysosomal Storage Disorders Research
- Insect and Arachnid Ecology and Behavior
- Bird parasitology and diseases
- Toxin Mechanisms and Immunotoxins
- Parasite Biology and Host Interactions
- Glycosylation and Glycoproteins Research
- Plant and animal studies
National Institute for Public Health and the Environment
2016-2025
Wageningen University & Research
2013-2024
Amsterdam University Medical Centers
2024
Sciensano (Belgium)
2019-2022
Health Forecasting
2020-2021
Utrecht University
1998-2019
Institute of Public Health Zadar
2015
National Institute of Public Health
2011
Institute of Molecular Life Sciences
2007
Amsterdam UMC Location University of Amsterdam
1998-2003
Giardia duodenalis, originally regarded as a commensal organism, is the etiologic agent of giardiasis, gastrointestinal disease humans and animals. Giardiasis causes major public veterinary health concerns worldwide. Transmission either direct, through faecal-oral route, or indirect, ingestion contaminated water food. Genetic characterization G. duodenalis isolates has revealed existence seven groups (assemblages A to G) which differ in their host distribution. Assemblages B are found many...
Due to increased travel, climatic, and environmental changes, the incidence of tick-borne disease in both humans animals is increasing throughout Europe. Therefore, extended surveillance tools are desirable. To accurately screen pathogens, a large scale epidemiological study was conducted on 7050 Ixodes ricinus nymphs collected from France, Denmark, Netherlands using powerful new high-throughput approach. This advanced methodology permitted simultaneous detection 25 bacterial, 12 parasitic...
Anaplasma phagocytophilum is the etiological agent of granulocytic anaplasmosis in humans and animals. Wild animals ticks play key roles enzootic cycles pathogen. Potential ecotypes A. have been characterized genetically, but their host range, zoonotic potential transmission dynamics has only incompletely resolved. The presence DNA was determined more than 6000 ixodid collected from vegetation wildlife, 289 tissue samples wild domestic animals, 69 keds deer, originating various geographic...
Glycosphingolipids are controlled by the spatial organization of their metabolism and transport specificity. Using immunoelectron microscopy, we localize to Golgi stack glycosyltransferases that produce glucosylceramide (GlcCer), lactosylceramide (LacCer), GM3. GlcCer is synthesized on cytosolic side must translocate across lumen for LacCer synthesis. However, only very little natural translocates in vitro. As reaches cell surface when vesicular trafficking inhibited, it a post-Golgi...
Antibodies against receptors that undergo transcytosis across the blood-brain barrier (BBB) have been used as vectors to target drugs or therapeutic peptides into brain. We recently discovered a novel single domain antibody, FC5, which transmigrates human cerebral endothelial cells in vitro and BBB vivo. The purpose of this study was characterize mechanisms FC5 endocytosis its putative receptor on brain cells. transport polarized, charge independent temperature dependent, suggesting...
Hard ticks have been identified as important vectors of rickettsiae causing the spotted fever syndrome. Tick-borne are considered to be emerging, but only limited data available about their presence in Western Europe, natural life cycle and reservoir hosts. Ixodes ricinus, most prevalent tick species, were collected tested from different vegetation types potential In one biotope area, annual seasonal variability infections stages determined for 9 years.The DNA human pathogen R. conorii well...
Neoehrlichia mikurensis s an emerging and vector-borne zoonosis: The first human disease cases were reported in 2010. Limited information is available about the prevalence distribution of Europe, its natural life cycle reservoir hosts. An Ehrlichia-like schotti variant has been described questing Ixodes ricinus ticks, which could be identical to mikurensis. Three genetic markers, 16S rDNA, gltA GroEL, Ehrlichia schotti-positive tick lysates amplified, sequenced compared sequences from Based...
Background. In the northern hemisphere, ticks of Ixodidae family are vectors diseases such as Lyme borreliosis, Rocky Mountain spotted fever and tick-borne encephalitis. Most these generalists have a three-host life cycle for which they dependent on three different hosts their blood meal. Finding out host species contribute most in maintaining pathogens transmit, is imperative understanding drivers behind dynamics disease.
Lyme borreliosis is the most common tick-borne human disease and caused by Borrelia burgdorferi sensu lato (s.l.). miyamotoi, a relapsing fever spirochaete, transmitted transovarially, whereas this has not been shown for B. (s.l). Therefore, (s.l) considered to cycle from nymphs larvae through vertebrates. Larvae of Ixodes ricinus are occasionally infected, but their vector competence never studied. We challenged 20 laboratory mice with field-collected I. ricinus. A subset these was analysed...
We examined the Borrelia burgdorferi sensu lato circulation in a tick community consisting of three species (Ixodes ricinus, I. frontalis, arboricola) with contrasting ecologies, but sharing two European songbird hosts (Parus major and Cyanistes caeruleus). Parus had highest infestation rates, primarily due to larger numbers probably because their greater low-level foraging. The prevalence feeding ticks did not significantly differ between bird species; however, P. particular hosted large...