A5029961929- Poisoning and overdose treatments
- Pesticide Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Suicide and Self-Harm Studies
- Electroconvulsive Therapy Studies
- Insect and Pesticide Research
- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Treatment of Major Depression
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects and Toxicity Studies
- Bone health and osteoporosis research
- Forensic Toxicology and Drug Analysis
- Paraquat toxicity studies and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience of respiration and sleep
- Hip and Femur Fractures
- Cardiac electrophysiology and arrhythmias
- Opioid Use Disorder Treatment
- Pesticide and Herbicide Environmental Studies
- Pharmacology and Obesity Treatment
- Substance Abuse Treatment and Outcomes
- Schizophrenia research and treatment
- Methemoglobinemia and Tumor Lysis Syndrome
- Environmental Toxicology and Ecotoxicology
The University of Sydney
2015-2024
Royal Prince Alfred Hospital
2015-2024
South Asian Clinical Toxicology Research Collaboration
2013-2024
University of Peradeniya
2013-2024
Children's Hospital at Westmead
2014-2024
Edith Cowan University
2024
Sydney Children’s Hospitals Network
2016-2024
Washington Poison Center
2024
Sydney Local Health District
2020-2023
Office of Energy Efficiency and Renewable Energy
2022
In the triennium 2006-2008, 261 women in UK died directly or indirectly related to pregnancy.The overall maternal mortality rate was 11.39 per 100,000 maternities.Direct deaths decreased from 6.24 maternities 2003-2005 4.67 2006-2008 (p = 0.02).This decline is predominantly due reduction thromboembolism and, a lesser extent, haemorrhage.For first time there has been inequalities gap, with significant decrease rates among those living most deprived areas and lowest socio-economic...
Background: There are difficulties with the diagnosis of serotonin toxicity, particularly use Sternbach’s criteria. Aim: To improve criteria for diagnosing clinically significant toxicity. Design: Retrospective analysis prospectively collected data Methods: We studied all patients admitted to Hunter Area Toxicology Service (HATS) following an overdose a serotonergic drug from January 1987 November 2002 (n = 2222). Main outcomes were: toxicity by clinical toxicologist, fulfilment and...
Background: Selective serotonin reuptake inhibitors (SSRIs) have increasingly replaced tricyclic antidepressants (TCAs) in the treatment of depression. They appear to be safer overdose, but there is little information on their spectrum toxicity or relative each agent. Objective: To determine effect SSRIs as a group, and five different SSRIs. Methods: A review consecutive SSRI poisoning admissions single toxicology unit. Outcomes examined were length stay [LOS], intensive care [ICU] admission...
In a prospective cohort study of patients presenting with pesticide self-poisoning, Andrew Dawson and colleagues investigate the relative human toxicity agricultural pesticides contrast it WHO classifications, which are based on in rats.
ADVERTISEMENT RETURN TO ISSUEPREVEnergy FocusNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.The Path to Perovskite Commercialization: A Perspective from United States Solar Energy Technologies OfficeTimothy D. Siegler*Timothy SieglerOak Ridge Institute of Science and Engineering, Oak Ridge, Tennessee 37830, States*[email protected]More by Timothy Sieglerhttps://orcid.org/0000-0001-6033-2232, Andrew DawsonAndrew DawsonSolar Office, Office Efficiency Renewable...
<h3>Abstract</h3> <b>Objective</b> To determine whether an intervention using postcards (postcards from the EDge project) reduces repetitions of hospital treated deliberate self poisoning. <b>Design</b> Randomised controlled trial. <b>Setting</b> Regional referral service for general poisoning in Newcastle, Australia. <b>Participants</b> 772 patients aged over 16 years with <b>Intervention</b> Non-obligatory eight 12 months along standard treatment compared alone. <b>Main outcome...
Selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have been regarded as less toxic in overdose than tricyclic antidepressants (TCAs). Within the TCAs, dothiepin has greater toxicity. Venlafaxine may be more SSRIs.To assess toxicity of SSRIs compared to other TCAs.Cohort study prospectively collected data from Hunter area, NSW, Australia.First admissions with antidepressant deliberate self-poisoning (DSP) (November 1994 April 2000) were identified; presence seizures,...
Abstract Severe organophosphorus or carbamate pesticide poisoning is an important clinical problem in many countries of the world. Unfortunately, little research has been performed and evidence exists with which to determine best therapy. A cohort study acute poisoned patients was established Sri Lanka during 2002; so far, more than 2000 have treated. protocol for early management severely ill, unconscious organophosphorus/carbamate-poisoned developed use by newly qualified doctors. It...
Serotonin syndrome is a potentially fatal and largely avoidable adverse drug reaction caused by serotonergic drugs. The steady increase in use of such drugs means all doctors need to be aware what serotonin how promptly recognise the determine if it life threatening.
Poisoning with organophosphorus (OP) insecticides is a major global public health problem, causing an estimated 200,000 deaths each year. Although the World Health Organization recommends use of pralidoxime, this antidote's effectiveness remains unclear. We aimed to determine whether addition pralidoxime chloride atropine and supportive care offers benefit.We performed double-blind randomised placebo-controlled trial (2 g loading dose over 20 min, followed by constant infusion 0.5 g/h for up...
Deliberate self-poisoning with older pesticides such as organophosphorus compounds are commonly fatal and a serious public health problem in the developing world. The clinical consequences of newer not well described. Such information may help to improve management inform pesticide regulators their relative toxicity. This study reports outcomes toxicokinetics neonicotinoid insecticide imidacloprid following acute humans.Demographic data were prospectively recorded patients exposure three...
Objective To investigate the effect of 3-year phased bans pesticides dimethoate and fenthion in 2008–2010, paraquat 2009–2011, on suicide mortality Sri Lanka. Methods Age-standardised overall, sex-specific, method-specific rates were calculated using Lankan police data (1989–2015). Using negative binomial regression models, we estimated change rate number deaths post-ban years (2011–15) compared to those expected based pre-ban trends (2001–10). Findings Overall dropped by 21% between 2011...
Context. The case fatality from acute poisoning with glyphosate-containing herbicides is approximately 7.7% the available studies but these have major limitations. Large prospective of patients self-poisoning known formulations who present to primary or secondary hospitals are needed better describe outcome herbicides. Furthermore, clinical utility glyphosate plasma concentration for predicting outcomes and guiding treatment has not been determined. Objective. To outcomes, dose–response,...
There is a paucity of robust epidemiological data on snakebite, and available from hospitals localized or time-limited surveys have major limitations. No study has investigated the incidence snakebite across whole country. We undertook community-based national survey model based geostatistics to determine incidence, envenoming, mortality geographical pattern in Sri Lanka.The was designed sample population distributed equally among nine provinces The number collection clusters divided...
Introduction The psychological impact of snakebite on its victims, especially possible late effects, has not been systematically studied. Objectives To assess delayed somatic symptoms, depressive disorder, post-traumatic stress disorder (PTSD), and impairment in functioning, among victims. Methods study had qualitative quantitative arms. In the arm, 88 persons who systemic envenoming following from North Central Province Sri Lanka were randomly identified an established research database...
Background Repetition of hospital-treated self-poisoning and admission to psychiatric hospital are both common in individuals who self-poison. Aims To evaluate efficacy postcard intervention after 5 years. Method A randomised controlled trial have self-poisoned: (eight 12 months) plus treatment as usual v. usual. Our primary outcomes were admissions (proportions event rates). Results There was no difference between groups for any repeat-episode (intervention group: 24.9%, 95% CI 20.6-29.5;...