A5008305793- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Psychiatric care and mental health services
- Personality Disorders and Psychopathology
- Psychosomatic Disorders and Their Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Advanced MRI Techniques and Applications
- Tryptophan and brain disorders
- Mental Health Treatment and Access
- Mental Health and Patient Involvement
- Psychotherapy Techniques and Applications
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Treatment of Major Depression
- Neural dynamics and brain function
- Counseling, Therapy, and Family Dynamics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Olfactory and Sensory Function Studies
- Autoimmune Neurological Disorders and Treatments
- Bioinformatics and Genomic Networks
The University of Melbourne
2011-2025
Orygen
2005-2025
Orygen Youth Health
2011-2024
Mental Health Australia
1998-2020
Monash University
2020
Melbourne Clinic
2005
Objective: Recognizing the prodrome of a first psychotic episode prospectively creates opportunity intervention, which could delay, ameliorate or even prevent onset. Valid criteria and reliable methodology for identifying possible prodromes are needed. This paper describes an instrument, Comprehensive Assessment At-Risk Mental States (CAARMS), has been designed such purpose. It two functions: (i) to assess psychopathology thought indicate imminent development first-episode disorder; (ii)...
<h3>Background</h3> Most disability produced by psychotic illnesses, especially schizophrenia, develops during the prepsychotic period, creating a case for intervention this period. However, only recently has it been possible to engage people in treatment phase. <h3>Methods</h3> A randomized controlled trial compared 2 interventions 59 patients at incipient risk of progression first-episode psychosis. We termed group<i>ultra-high risk</i>to emphasize enhanced vs conventional genetic...
Background The identification of people at high risk becoming psychotic within the near future creates opportunities for early intervention prior to onset psychosis prevent or minimise later ill-health. present study combines current knowledge about factors schizophrenia with our prodromes in an attempt identify a group particularly vulnerable impending psychosis. We wanted likelihood transition follow-up period 12 months, and determine rate this group. Method Various state trait were used...
There is growing interest in the prodromal stage of psychotic disorders, with many services now providing care for these "ultra high risk" (UHR) individuals. However, a reduction rate transition to psychosis has been suspected over last few years. This implications use interventions this population and validity research findings. study examined one UHR service, Personal Assessment Crisis Evaluation Clinic, years 1995–2000 investigated possible causes reduction. was evidence declining rate,...
<h3>Importance</h3> The ultra high-risk (UHR) criteria were introduced to prospectively identify patients at high risk of psychotic disorder. Although the short-term outcome UHR has been well researched, long-term is not known. <h3>Objective</h3> To assess rate and baseline predictors transition disorder in up 15 years after study entry. <h3>Design</h3> Follow-up a cohort recruited participate research studies between 1993 2006. <h3>Setting</h3> Personal Assessment Crisis Evaluation (PACE)...
Objective: Recognizing the prodrome of a first psychotic episode prospectively creates opportunity intervention, which could delay, ameliorate or even prevent onset. Valid criteria and reliable methodology for identifying possible prodromes are needed. This paper describes an instrument, Comprehensive Assessment At-Risk Mental States (CAARMS), has been designed such purpose. It two functions: (i) to assess psychopathology thought indicate imminent development first-episode disorder; (ii)...
While cognitive deficits are frequently reported in psychotic disorders, it is unclear whether these impairments predate the onset of illness and to what extent they predictive later transition psychosis.The authors studied 37 healthy volunteers 98 symptomatic, help-seeking patients meeting inclusion criteria a treatment program for people at ultra-high risk psychosis. Of ultra-high-risk patients, 34 (34.7%) developed psychosis over course investigation. Premorbid current IQ, attention,...
OBJECTIVE: Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these predate illness onset. METHOD: The ability 81 at ultra-high risk for psychosis was examined relation to that 31 healthy comparison subjects. Twenty-two the ultra-high-risk (27.2%) later became psychotic, and 12 were diagnosed with schizophrenia spectrum disorder. RESULTS: There significant impairment group...
Bechdolf A, Thompson Nelson B, Cotton S, Simmons MB, Amminger GP, Leicester Francey SM, McNab C, Krstev H, Sidis McGorry PD, Yung AR. Experience of trauma and conversion to psychosis in an ultra‐high‐risk (prodromal) group. Objective: We aimed replicate a recent finding high prevalence history patients at ‘ultra‐high risk’ (UHR) psychotic disorder investigate whether predicts this population. Method: A consecutive sample UHR was assessed. History accessed with the General Trauma...
Cognitive therapy and/or low-dose antipsychotic administered during the prodromal phase of schizophrenia may prevent or delay onset full-blown illness. However, it is unclear which these treatments are most effective, how long treatment should be given, and whether effects will sustained over a prolonged period.In order to examine issues, we conducted randomized controlled trial cognitive + risperidone; placebo; supportive placebo in young people at ultra high risk for developing psychotic...
Article Abstract Objective: The ultra-high risk clinical phenotype is associated with substantial distress and functional impairment confers a greatly enhanced for transition to full-threshold psychosis. A range of interventions aimed at relieving current symptoms reducing the psychosis has shown promising results, but optimal type sequence intervention remain be established. aim this study was determine which most effective preventing psychosis: cognitive therapy plus low-dose risperidone,...
Changes in brain volume are a common finding Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous longitudinal suggest that deficits progress illness duration. However, major unresolved question concerns whether these changes driven by the underlying or represent iatrogenic effects antipsychotic medication. In this study, 62 antipsychotic-naïve patients first-episode (FEP) received either second-generation (risperidone paliperidone) placebo pill over treatment...
Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen progression, but the mechanisms underlying specific spatial patterning of these changes unknown.
The present study describes the results of pilot testing a therapy we have developed for people with first-episode psychosis. Cognitively-oriented psychotherapy early psychosis (COPE) is aimed at facilitating adjustment person, and preventing or alleviating secondary morbidity in wake first psychotic episode.Eighty formed three groups: those who were offered accepted COPE (COPE subjects); refused (refusal neither nor any other continuing treatment from our service (control subjects)....
Intervention in the prodromal phase of schizophrenia and related psychotic disorders may prevent or delay onset these disorders, reduce severity psychosis. Identifying prodrome is difficult, however, because its non-specific symptoms wide symptom variability between individuals. Over past 15 years, we have investigated developed criteria for detecting people suspected experiencing a (ie, they are thought to be at imminent risk disorder). About 35% those meeting our disorder within 12 months....
Abstract This triple-blind (participants, clinicians, and researchers) randomized controlled noninferiority trial examined whether intensive psychosocial intervention (cognitive-behavioral case management, CBCM) for first-episode psychosis (FEP) in 15–25 year-olds managed a specialized early service was noninferior to usual treatment of antipsychotic medication plus CBCM delivered during the first 6 months treatment. To maximize safety, participants were required have low levels suicidality...
Altered functional connectivity (FC) is a common finding in resting-state magnetic resonance imaging (rs-fMRI) studies of people with psychosis, yet how FC disturbances evolve the early stages illness, and antipsychotic treatment influences these disturbances, remains unknown.To investigate longitudinal changes antipsychotic-naive antipsychotic-treated patients first-episode psychosis (FEP).This secondary analysis triple-blind, randomized clinical trial was conducted over 5-year recruitment...