A5027828946- Advanced MRI Techniques and Applications
- Renal Transplantation Outcomes and Treatments
- MRI in cancer diagnosis
- Lanthanide and Transition Metal Complexes
- Electron Spin Resonance Studies
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Spine and Intervertebral Disc Pathology
- Renal and Vascular Pathologies
- Glioma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Photoacoustic and Ultrasonic Imaging
- Musculoskeletal pain and rehabilitation
- Cardiac Valve Diseases and Treatments
- Adipose Tissue and Metabolism
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Atomic and Subatomic Physics Research
- Dialysis and Renal Disease Management
- Radiomics and Machine Learning in Medical Imaging
- Multiple and Secondary Primary Cancers
- Bone and Joint Diseases
- Advanced Fluorescence Microscopy Techniques
- Nuclear Physics and Applications
- Polyomavirus and related diseases
Federico II University Hospital
2009-2025
University of Illinois Chicago
2016-2022
Resonance Research (United States)
2022
University of Naples Federico II
2008-2020
Fondazione IRCCS Istituto Neurologico Carlo Besta
2013-2017
Northwestern University
2016
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2015
Summary Objective Hippocampal sclerosis ( HS ) is the major structural brain lesion in patients with temporal lobe epilepsy TLE ). However, its internal anatomic structure remains difficult to recognize at 1.5 or 3 Tesla T magnetic resonance imaging MRI ), which allows neither identification of specific pathology patterns nor their proposed value predict postsurgical outcome, cognitive impairment, underlying etiologies. We aimed identify subtypes resected surgical samples on 7 by...
Biglycan is an important proteoglycan of the extracellular matrix intervertebral disc (IVD), and its decrease with aging has been correlated IVD degeneration. deficient (Bgn−/0) mice lack this protein undergo spontaneous degeneration aging, thus representing a valuable in vivo model for preliminary studies on therapies human progressive The purpose present study was to assess possible beneficial effects adipose-derived stromal cells (ADSCs) implants Bgn−/0 mouse model. To evaluate ADSC...
Gold nanoparticles coated with fluorinated ligands (F-MPCs) present features suitable for (19)F MRI as observed from phantom experiments. Cellular uptake, by HeLa cells, and toxicity of fluorescent dye-decorated F-MPCs are presented together their ability to bind hydrophobic molecules allowing a potential combination targeting, delivery imaging features.
Purpose To characterize the relaxation properties of reactive oxygen species (ROS) for development endogenous ROS contrast magnetic resonance imaging (MRI). Materials and Methods ROS‐producing phantoms animal models were imaged at 9.4T MRI to obtain T 1 2 maps. Egg white samples treated with varied concentrations hydrogen peroxide (H O ) used evaluate effect produced in up 4 hours. pH temperature changes due H treatment egg also monitored. The influences from itself evaluated bovine serum...
To characterize the anatomy of venous outflow mouse brain using different imaging techniques. Ten C57/black male mice (age range: 7-8 weeks) were imaged with high-frequency Ultrasound, Magnetic Resonance Angiography and ex-vivo Microcomputed tomography head neck. Under general anesthesia, Ultrasound neck veins was performed a 20MHz transducer; data collected on 9.4T or 7T scanners, angiography obtained by filling vessels radiopaque inert silicone rubber compound. All procedures approved...
Immunodeficiency is associated with higher cancer incidence. However, it unknown whether there a link between immunodeficiency and development of multiple primary malignancies. In the present study we analyse this focusing on kidney-transplanted patients, as they are at risk developing due to chronic assumption immunosuppressants. We followed up 1200 patients who underwent kidney transplantation 1980 2012. A total 77/1200 developed 24 them cancers. Most cancers were synchronous...
To implement omega plot method for in vivo mapping of proton exchange rates human brain by taking into account the water direct saturation (DS) effect and multiple transfer exchanging species vivo.Four Z-spectra were collected with chemical (CEST) power =1, 2, 3 & 4 µT. Water DS was estimated fitting Z-spectrum to a linear combination Lorentzian components its contribution signal subsequently removed. Exchange rate maps derived plot, consisting fitting inverse intensity, Mz /(M0-Mz ), as...
Background Perfusion weighted imaging (PWI) can be used to measure key aspects of tumor vascularity in vivo and recent studies suggest that perfusion may useful the early assessment response angiogenesis inhibitors. Aim this work is compare Parametric Response Maps (PRMs) with Region Of Interest (ROI) approach analysis changes induced by bevacizumab irinotecan recurrent glioblastomas (rGBM), evaluate if blood volume measured MRI predict clinical outcome. Methods 42 rGBM patients KPS ≥50 were...
Background Brown adipose tissue (BAT) has a great relevance in metabolic diseases and been shown to be reduced obesity insulin resistance patients. Currently, Dixon MRI is used calculate fat‐water fraction (FWF) differentiate BAT from white (WAT). However, it may fail areas of phase wrapping introduce swapping artifacts. Purpose To investigate the capacity Z‐spectrum imaging (ZSI) for identification vivo. Study Type Retrospective study. Specimens: WAT, BAT, lean healthy mice. Animals: Four...
Background The detection of tissue reactive oxygen species (ROS) using endogenous MRI methods has great potential applications in research and the clinic. We recently demonstrated that ROS produce a significant T 1 ‐shortening effect. However, or ‐weighted contrast is not specific, as there are many other factors alter . Purpose To investigate whether presence alters environmental conditions such proton exchange rate ( K ex ) to improve specificity MRI. Study Type Prospective....
Introduction . SARS‐CoV‐2 is a virus that causes potentially deadly syndrome affects especially the respiratory tract. Kidney‐transplanted patients are immunosuppressed and more susceptible to viral infections. We have examined our transplantation activity explore future role of kidney from deceased living donors in COVID‐19 era. Patients Methods The transplant center Naples (one two centers Campania, South Italy) continued during pandemic. analysed transplants carried out between March 9...