A5064838336- Lysosomal Storage Disorders Research
- Neuroscience and Neuropharmacology Research
- Glycogen Storage Diseases and Myoclonus
- Carbohydrate Chemistry and Synthesis
- Genetic and Kidney Cyst Diseases
- Trypanosoma species research and implications
- Biomedical Research and Pathophysiology
- Renal Diseases and Glomerulopathies
- Cellular transport and secretion
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Neural dynamics and brain function
- Metabolism and Genetic Disorders
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Neurological disorders and treatments
- Cardiomyopathy and Myosin Studies
- Autoimmune Bullous Skin Diseases
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
University of Naples Federico II
2016-2025
Gastroenterology Hospital "Saverio de Bellis"
2019-2025
Federico II University Hospital
2015-2024
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2024
John Wiley & Sons (United States)
2023-2024
Creative Commons
2023
National Research Council
2015-2023
Institute for Biomedical Research and Innovation
2023
Regione Campania
2021
Istituti di Ricovero e Cura a Carattere Scientifico
1998-2019
The effect of tetanic activation corticostriatal glutamatergic fibers was studied in striatal slices by utilizing extracellular and intracellular recording techniques. Tetanic stimulation produced a long- term synaptic depression (LTD) (> 2 h) both extracellularly recorded field potentials intracellularly EPSPs. LTD not coupled with changes intrinsic membrane properties the neurons. In some neurons, repetitive cortical short-term posttetanic potentiation (1–3 min). Subthreshold...
We have studied the effects of tetanic stimulation corticostriatal pathway on amplitude striatal excitatory synaptic potentials. Recordings were obtained from a slice preparation by utilizing both extracellular and intracellular techniques. Under control condition (1.2 mM external Mg2+), postsynaptic potentials (EPSPs) evoked cortical reversibly blocked 10 microM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an antagonist dl-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)...
The outcome of steroid-dependent or frequently relapsing nephrotic syndrome minimal change disease (MCD), mesangial proliferative GN (MesGN), FSGS may be poor and with major treatment toxicity. This academic, multicenter, off-on trial (ClinicalTrials.gov #NCT00981838) primarily evaluated the effects rituximab therapy followed by immunosuppression withdrawal on recurrence in 10 children 20 adults MCD/MesGN (n=22) who had suffered ≥2 recurrences over previous year were steroid-induced...
Background: Obesity impairs renal function through direct mechanisms, such as proinflammatory adipocytokine production, and indirect including obesity-related comorbidities. Despite the increasing prevalence of obesity chronic kidney disease (CKD), clinical guidelines for their combined management remain lacking. Very Low Energy Ketogenic Therapy (VLEKT) has demonstrated efficacy in weight loss, but evidence on its safety individuals with mild impairment is limited. This study aimed to...
Stimulation of dopamine (DA) receptors in the striatum is essential for voluntary motor activity and generation plasticity at corticostriatal synapses. In present study, mice lacking DA D 1 have been used to investigate involvement -like class (D 5 ) locomotion long-term depression (LTD) potentiation (LTP). Our results suggest that exert distinct actions on both activity-dependent synaptic spontaneous activity. Accordingly, ablation disrupted LTP, whereas pharmacological blockade prevented...
By stimulating distinct receptor subtypes, dopamine (DA) exerts presynaptic and postsynaptic actions on both large aspiny (LA) cholinergic fast-spiking (FS) parvalbumin-positive interneurons of the striatum. Lack receptor- isoform-specific pharmacological agents, however, has hampered progress toward a detailed identification specific DA receptors involved in these actions. To overcome this issue, present study we used four different mutant mice which expression was ablated. In D1 null mice,...
High-frequency stimulation (HFS) of corticostriatal glutamatergic fibers induces long-term depression (LTD) excitatory synaptic potentials recorded from striatal spiny neurons. This form LTD can be mimicked by zaprinast, a selective inhibitor cGMP phosphodiesterases (PDEs). Biochemical analysis shows that most the PDE activity is calmodulin-dependent and inhibited zaprinast. The zaprinast-induced occludes further tetanic vice versa. Both forms plasticity are blocked intracellular...
The interactions between N‐methyl‐ d ‐aspartate (NMDA) and metabotropic glutamate receptors (mGluRs) were investigated in striatal slices, by utilizing intracellular recordings, both current‐ voltage‐clamp mode. Bath‐application (50 μ m ) or focal application of NMDA induced a transient membrane depolarization, while the mode, caused inward current. Following bath‐application non‐selective mGluR agonist 1 S ,3 R ‐aminocyclopentane‐1,3‐dicarboxylic acid (1 ‐ACPD, 10 ), responses reversibly...
Studies in the last 15 years have shown a high prevalence of sleep disorders maintenance haemodialysis (HD) patients.To investigate whether new technical and therapeutic advances decade had positive impact on disturbances HD patients: 694 patients (384 males, 310 females) were surveyed using specific questionnaire; their clinical, lifestyle dialysis data also recorded.Forty-five per cent (n=311; 156 155 complained insomnia, defined either by delayed onset and/or night-time waking, included...
Patients with Fabry disease (FD) are at a high risk for developing chronic kidney and cardiovascular disease. The availability of specific but costly therapy has elevated the profile this rare condition. This KDIGO conference addressed controversial areas in diagnosis, screening, management FD, included enzyme replacement nonspecific standard-of-care various manifestations FD. Despite marked advances patient care improved overall outlook, there is need to better understand pathogenesis...
Iron deficiency is a common cause of anaemia in non-dialysis chronic kidney disease (ND-CKD). Controversies exist about the optimal route administration for iron therapy. Liposomal iron, new generation oral with high gastrointestinal absorption and bioavailability low incidence side effects, seems to be promising strategy replacement. Therefore, we conducted study determine whether liposomal compared intravenous (IV) improves ND-CKD patients. In this randomized, open-label trial, 99 patients...
Alterations in blood–brain barrier permeability have been proposed to represent a relevant factor contributing Parkinson’s disease progression. However, few studies addressed this issue patients at different stages of disease. Albumin was measured cerebrospinal fluid and serum samples obtained from 73 non-demented subjects with idiopathic 47 age-matched control subjects. The albumin ratio (AR) calculated assess blood-cerebrospinal function. group included 46 Hoehn-Yahr staging between 1 2...
Anderson-Fabry disease (FD) is a rare, progressive, multisystem storage disorder caused by the partial or total deficit of lysosomal enzyme α-galactosidase A (α-Gal A). It an X-linked, enzymopathy due to mutations in galactosidase alpha gene (GLA), encoding α-Gal A. To date, more than 900 this have been described. In our laboratories, study genetic and enzymatic alterations related FD was performed about 17,000 subjects with symptomatology referable disorder. The accumulation...