A5009904742- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Connexins and lens biology
- Advanced Neuroimaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Functional Brain Connectivity Studies
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Trauma and Emergency Care Studies
- Ginseng Biological Effects and Applications
- Pituitary Gland Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Kidney Injury Research
- Growth Hormone and Insulin-like Growth Factors
- Heme Oxygenase-1 and Carbon Monoxide
- Neurogenesis and neuroplasticity mechanisms
- Bone and Joint Diseases
- Biomarkers in Disease Mechanisms
- Glycogen Storage Diseases and Myoclonus
- Mast cells and histamine
Pudong New Area People's Hospital
2012-2022
Abstract Alzheimer's disease (AD) is a progressive and age‐related neurological dysfunction. Abundant data have profiled microRNA (miR) patterns in healthy, aging brain, the moderate late‐stages of AD. Herein, this study aimed to explore whether miR‐326 could influence neuron apoptosis AD mice how functions process. The candidate differentially expressed gene VAV1 was obtained by microarray analysis, miRNAs that regulate were predicted. Luciferase activity determination confirmed as target...
The study aims to investigate the effects of long noncoding RNA (lncRNA) transmitted nuclear factor-κB interacting lncRNA (NKILA)-containing astrocyte-derived small extracellular vesicles (EVs) on traumatic brain injury (TBI). TBI was modeled in vitro by exposing human neurons mechanical and vivo controlled cortical impact a mouse model. gain- loss-function approaches were conducted injured explore role NKILA, microRNA-195 (miR-195) nucleotide-binding leucine-rich repeat containing family...
BackgroundSleep disturbance is very common following traumatic brain injury (TBI), which may initiate or exacerbate a variety of co-morbidities and negatively impact rehabilitative treatments. To date, there are paradoxical reports regarding the associations between inherent characteristics TBI sleep in population. The current study was designed to explore relationship presence identify factors closely related Methods98 patients (72 males, mean age ± SD, 47 13 years, range 18-70) were...
Traumatic brain injury (TBI) caused by the external force leads to neuronal dysfunction and even death. TBI has been reported significantly increase phosphorylation of glial gap junction protein connexin 43 (Cx43), which in turn propagates damages into surrounding tissues. However, neuroprotective anti-apoptosis effects glia-derived exosomes have also implicated recent studies. Therefore, we detected whether TBI-induced Cx43 would promote exosome release rat brain. To generate model, adult...
Exogenous insulin like growth factor-1 (IGF-1) is known to be neuroprotective in animal models with brain insults, while it can also cause hyperexcitability rodents. In this regard, the role of endogenous IGF-1 responses insults excitotoxicity, a common pathology injuries, remains elucidated. Here, we investigated potential cell-specific kainic acid (KA) -induced degeneration neurons.Kainic was given primary cultured cortical neurons and co-cultured astrocytes were added as supportive...
Since progressive intracranial haemorrhage (PIH) was introduced in neurosurgical literatures, several studies have been performed. PIH has shown to be associated with a high increase the risk of clinical worsening and related morbidity mortality as well. So, early detection prediction is practically important situation.To investigate factors patients acute traumatic brain injury (TBI) analyse their significances.PIH confirmed by comparing first repeated CT scans. Data compared included...
Connexins are a family of transmembrane proteins that form gap junctions, which important for diffusion cytosolic factors such as ions and second messenger signaling molecules. Our previous study has shown Connexin40 (Cx40), one dominant connexin expressed in brain, was involved brain injury. In this study, Cx43, another investigated. Using bilateral common carotid artery occlusion-induced ischemia rat model, we tested the expression phosphorylation level Cx43 well heteromeric Cx40/Cx43...
Objective: To study the dynamic changes of pituitary hormones in traumatic brain injury (TBI) and to correlate severity neurological outcome. Patients Methods: Dynamic were evaluated 164 patients with TBI on day-1, day-7, day-14, day-21, day-28 post injury. Admission long-term outcome assessed Glasgow Coma Scale (GCS) score Outcome (GOS) score. The hormonal correlated Results: Of included study, dysfunction was found 84 remaining 80 function normal. Most hormone deficiencies observed...
Background: Oxidative stress is an important factor in the pathophysiologic changes after traumatic brain injury (TBI). Connexin43 (Cx43) was reported to contribute cerebral damage. However, impacts of Cx40 have not been investigated detail. Objective: In present study, we hypothesize d that involved oxidative stress-induced TBI. Methods: The controlled cortical impact (CCI) model introduced Wistar rats as a TBI model. Neurological deficits, and were evaluated N-acetylcysteine (NAC)-treated...
The authors undertook this study to evaluate the effects of continuous intracranial pressure (ICP) monitoring-directed mannitol treatment on kidney function in patients with moderate or severe traumatic brain injury (TBI).One hundred sixty-eight TBI were prospectively assigned an ICP monitoring group a conventional control based Brain Trauma Foundation guidelines. Clinical data included dynamic changes patients' blood concentrations cystatin C, creatinine (Cr), and urea nitrogen (BUN); use;...
Haemorrhagic stroke is one of the leading causes death and most common cause long-term adult disability. An accurate estimation prognosis very important for haemorrhagic patients. Impairment motor function caused by pyramidal tract injury in these In this study, we performed MR diffusion tensor tractography (DTT) to predict impairment patients with basal ganglion haemorrhage explore its clinical value.Diffusion was 33 ganglia within 2 weeks after onset visualize course tracts (PTs), were...
Intracranial-pressure (ICP) monitoring is considered standard care for severe traumatic brain injury and used frequently, but the efficacy of treatment based on in patients with hemorrhagic stroke has not been rigorously assessed. In this study, we investigated clinical value ICP stroke. We conducted a randomized, unblinded, controlled trial which 90 were randomly assigned to or control group. The primary outcome was composite incidence rate hematoma enlargement secondary herniation....
The relationship between microstructural abnormality in patients with traumatic brain injury (TBI) and hormone-secreting status remains unknown. In this study, the authors aimed to identify role of apparent diffusion coefficient (ADC) using a diffusion-weighted imaging (DWI) technique evaluate association such changes hypopituitarism TBI.Diffusion-weighted images were obtained 164 consecutive TBI within 2 weeks after generate pituitary ADC as measure change. Patients further grouped into...
Although there are a certain number of studies dedicated to the disturbances dopaminergic system induced by traumatic brain injury (TBI), associations abnormal systems with post-traumatic anxiety and depressive disorders their underlying mechanisms have not been clarified yet. In midbrain, neurons mainly situated in substantia nigra (SN) ventral tegmental area (VTA). Thus, we selected SN VTA as regions interest performed seed-based global correlation evaluate altered functional connectivity...
Background: Traumatic brain injury (TBI) often results in persistent cognitive impairment and psychiatric symptoms, while lesion location severity are not consistent with its clinical complaints. Previous studies found deficits disorders following TBI considered to be associated prefrontal medial temporal lobe lesions, however, the extent of contusions cannot fully explain patient′s impairments. Thus, we try find structural changes gray matter (GM) white (WM), clarify their correlation...
Gender may be related with the outcome of patients acute traumatic brain injury (TBI). We explored effect gender on 7145 TBI. There was no statistical difference between male and female sex in causes trauma, age, Glasgow Coma Scale score, computed tomgraphy findings, surgical management. The mortality TBI males females 7.48% 7.22%, respectively, corresponding unfavorable outcomes 16.05% 17.23%, respectively (p > 0.05 both cases). 1626 severe 19.68% 20.72%, 46.96% 48.85%, Our data suggest...
Radiation therapy is widely used for the treatment of pituitary adenomas. Unfortunately, it might raise risk ischemic stroke, with neuroinflammation being a major pathological process. Astrocytes are most abundant cell type in central nervous system and have been reported playing important roles stroke.Here we studied how γ-radiation would introduce astrocytes into detrimental state provide new theory evidence target clinical management inflammation- related neural damage after...
To investigate the dynamic change in serum Tau protein early after acute traumatic brain injury (TBI) and its association with neurological outcome cognitive function.Around 229 patients TBI 30 healthy subjects were evaluated for levels of on 1, 3, 5, 7, 14 days TBI. The relationships initial GCS GOS at 6 months post-injury also analyzed. Further, 95 assessed their function Montreal assessment (MoCA) score.Serum was significantly higher days. each point lower respectively mild than that...