A5100742378- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cervical Cancer and HPV Research
- Galectins and Cancer Biology
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Crystallography and molecular interactions
- Anesthesia and Neurotoxicity Research
- Trauma and Emergency Care Studies
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Ferroptosis and cancer prognosis
- Genital Health and Disease
- Cancer Research and Treatments
- Pregnancy and preeclampsia studies
- Pelvic floor disorders treatments
- Cancer-related gene regulation
- Kruppel-like factors research
- Bladder and Urothelial Cancer Treatments
- Sirtuins and Resveratrol in Medicine
- Cancer-related Molecular Pathways
- Intracerebral and Subarachnoid Hemorrhage Research
First Affiliated Hospital of Jinan University
2024-2025
Zhejiang University
2004-2025
First Affiliated Hospital Zhejiang University
2020-2025
Jinan University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2009-2023
Sun Yat-sen University
2018-2023
Xi'an Jiaotong University
2020-2021
Third Affiliated Hospital of Sun Yat-sen University
2018-2020
Shanxi Medical University
2020
Shanghai Jiao Tong University
2020
We have taken a genomic approach to examine global gene expression in the maize endosperm relation dosage and parental effects. Endosperm of eight hybrids generated by reciprocal crosses their seven inbred parents were sampled at three developmental stages: 10, 14, 21 days after pollination (DAP). These samples subjected GeneCalling, an open-ended mRNA-profiling technology, which simultaneously analyzes thousands genes. Results indicated that overall level was dosage-dependent, is,...
Local radiotherapy is the major therapeutic approach to control inoperable cervical cancer. In this study, we analyzed local immune microenvironment of cancer before and after clinical radiation therapy investigate whether tumor response due immunomodulation. A total 59 patients with pathologically diagnosed cancers classified according International Federation Obstetrics Gynecology (FIGO) criteria were recruited. The treated their disease status standard regimens. For each patient, biopsies...
Persistent infection with high‑risk human papillomavirus is known to cause cervical cancer. The binding of the costimulatory factors, Tim‑3 and galectin‑9, can immune tolerance lead escape during carcinogenesis. Epigenetic regulation essential for Tim‑3/galectin‑9 expression, which affects outcome local cancer infection. Hence, exploring epigenetic regulatory mechanisms signaling by great interest investigating through these proteins are regulated in tumorigenesis. In this study, we report...
BACKGROUND:To evaluate the diagnostic performance of MRI and 3D-TVS for assessment deep myometrial invasion (MI), cervical involvement (CI), Lymph node metastases (LNM) in endometrial cancer staging before surgery. MATERIAL AND METHODS:From January 2016 to December 2017, we reviewed data from 314 women with who underwent preoperative The sensitivity, specificity, PPV, NPV, accuracy detecting MI, CI, LNM were estimated based on ultimate pathology results. RESULTS:The diagnosis MI 89.19%,...
Abstract Background Methylation of histone 3 at lysine 9 (H3K9) and DNA methylation are epigenetic marks correlated with genes silencing. The tumor microenvironment significantly influences therapeutic responses clinical outcomes. epigenetic-regulation mechanism the costimulatory factors Tim-3 galectin-9 in cervical cancer remains unknown. Methods status HAVCR2 LGALS9 were detected by MS-PCR tissues cell lines. underlying molecular SUV39H1-DNMT3A-Tim-3/galectin-9 regulation was elucidated...
Daily wake-up has been implemented widely in intensive care units (ICU) and could improve the patients' prognosis. However, little is known about benefit of early neurological test (ENWT) patients with acute traumatic brain injury (TBI). We aimed to investigate role ENWT as a clinical monitoring tool for TBI its association This an observational retrospective study included intubated continuously sedated ICU, all data were extracted from three tertiary hospitals China. The main exposure...
Preeclampsia is a significant pregnancy disorder with an unknown cause, mainly attributed to impaired spiral arterial remodeling.
Background: Large cranial defects combined with hydrocephalus after decompressive craniectomy are a common, harsh reality among patients head trauma. Typically, shunt is first used to relieve the hydrocephalus. However, subsequently may develop severe sinking scalp flap over skull defect before cranioplasty, which would make procedure difficult.Methods: This problem was overcome by temporarily adjusting pressure using programmable ventriculoperitoneal tube, allowed expansion of depressed and...
The disequilibrium of local immune microenvironment is an essential element during tumorigenesis. By conducting real-time polymerase chain reaction, we identified the mRNA level factors, FoxP3 (forkhead box protein P3), CCL22/CCR4 (chemokine (C-C motif) ligand 22/CC chemokine receptor 4), OX40L/OX40 (tumor necrosis factor superfamily member 4/tumor 4) and Smad3 (SMAD family 3) in neoplastic foci its periphery tissues from 30 cases squamous cervical carcinoma 20 normal cervix. FoxP3, CCL22...
ABSTRACT Introduction Although exercise is a safe, cost-effective, and therapeutic poststroke therapy, the proper time window dosage of are still unknown. We aim to determine optimal combination intensity by assessing infarct volume, neurological recovery, underlying mechanisms in middle cerebral artery occlusion rats. Methods The study contains two parts: time-window experiments. experiment assessed effects moderate-intensity that was initiated at 24, 48, 72, 96 h control. In experiment,...
Pelvic organ prolapses (POP) notably reduces the quality of life in elderly populations due to bladder and bowel dysfunction, incontinence, coital problems. Extracellular matrix (ECM) disorder is a pivotal event progression POP, but date, its specific underlying mechanism remains unclear. The ligaments patients with POP healthy controls were collected compare expression Homeobox11 (HOXA11) transforming growth factor β (TGF‑β1) via immunohistochemical analysis. HOXA11 TGF‑β1 overexpressed or...
In the present study, we combined a nanofibrous polylactic acid (PLA) scaffold fabricated by electrospinning with polypropylene (PP) material to generate new type of mesh for hernia repair.The PLA/PP was tested tensile testing, in vitro cytocompatibility and degradation. A total 90 rats were randomly allocated PLA/PP, PP polyester (PE) groups vivo study evaluate properties mesh.PLA/PP had superior mechanical properties. It also resulted less inflammation adhesion formation (p < 0.05), which...
This study aimed to investigate the characteristics of female high‐risk human papillomavirus (HR‐HPV) infection in Shaanxi province China. A total 14 111 women were enrolled for HPV genotyping test, and a cytology, and/or cervix biopsy performed partial women. Of these women, rate was 30.21%, 26.73% caused by HR‐HPV. The most common HR‐HPV genotypes HPV‐16, HPV‐58, HPV‐52, HPV‐18, HPV‐31. prevalence among older than 50 years significantly higher other groups ( P < 0.05). main carcinogenic...
To evaluate the effectiveness of Human papillomavirus16/18 infection referral to colposcopy in cervical cancer screening for women aged 25 years and older Chinese northwest region Shaan'xi province. A total 2224 were diagnosed with primary high‐risk HPV by HPV‐DNA genotyping technology during August 2014 2015. 1916 cases referred histological evidence enrolled, including 1124 HPV16/18 genotype 792 other High‐risk human papillomavirus genotypes. HR‐HPV positive colposcopy. The distribution...
Gender may be related with the outcome of patients acute traumatic brain injury (TBI). We explored effect gender on 7145 TBI. There was no statistical difference between male and female sex in causes trauma, age, Glasgow Coma Scale score, computed tomgraphy findings, surgical management. The mortality TBI males females 7.48% 7.22%, respectively, corresponding unfavorable outcomes 16.05% 17.23%, respectively (p > 0.05 both cases). 1626 severe 19.68% 20.72%, 46.96% 48.85%, Our data suggest...