A5033856578- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Renal cell carcinoma treatment
- Pelvic and Acetabular Injuries
- Antioxidant Activity and Oxidative Stress
- Venous Thromboembolism Diagnosis and Management
- Orthopaedic implants and arthroplasty
- NF-κB Signaling Pathways
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Chromatin Remodeling and Cancer
- Endometrial and Cervical Cancer Treatments
- Nanoparticles: synthesis and applications
- Vascular Procedures and Complications
- Nanoparticle-Based Drug Delivery
- Urinary and Genital Oncology Studies
- Photodynamic Therapy Research Studies
Renmin Hospital of Wuhan University
2017-2021
Wuhan University
2017-2021
Jilin University of Chemical Technology
2019
Cardiovascular Research Center
2007
The mortality rate associated with ovarian cancer ranks the highest among gynecological malignancies. However, cause and underlying molecular events of are not clear. Here, we applied integrated bioinformatics to identify key pathogenic genes involved in reveal potential mechanisms.The expression profiles GDS3592, GSE54388, GSE66957 were downloaded from Gene Expression Omnibus (GEO) database, which contained 115 samples, including 85 cases samples 30 normal samples. three microarray datasets...
Abstract Insufficient trophoblast invasion is the key factor for occurrence of recurrent spontaneous abortions (RSA). Our previous studies identified Yin Yang 1 (YY1) as a transcription involved in regulation invasiveness at maternal–fetal interface. Long noncoding RNAs (lncRNAs) can regulate gene expression and autophagy many ways. The purpose this study was to explore relationship between YY1 lncRNAs mechanism by which affect biological behavior trophoblasts. Bioinformatic analysis...
Ovarian cancer (OC) has the highest mortality rate among female malignant tumors, and OC commonly relapses metastasizes. The mechanisms underlying occurrence development of ovarian are numerous complicated. aim present study was to explore an important molecular mechanism that may provide a theoretical basis for clinical treatment cancer. In study, expression level miR‑21 analyzed in specimens, normal epithelial cells three different cell lines. Then, vitro experiments were performed...
Hepatocellular carcinoma (HCC) ranks fifth among common cancers and is the second most cause of cancer-related mortality worldwide. This study aimed at identifying an immune-related long noncoding RNA (lncRNA) signature as a potential biomarker with prognostic value to improve early diagnosis provide therapeutic targets for HCC patients. The subjects this were samples complete transcriptome data clinical information downloaded from Cancer Genome Atlas (TCGA) database. We then extracted mRNA...
Abstract Background Ovarian cancer (OC) has the highest mortality rate in gynecologic tumors. Despite decades of continuous efforts, survival patients not improved significantly, mostly due to drug resistance. Exosomes are hot topics recent years. Cells can affect biological behaviors other cells by transferring exosomes. So far, numerous researchers have found that tumor secrete exosomes which play a important role development Solid tumors promote angiogenesis. When resistance occurs, it...
Abstract In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal carcinoma (ccRCC), by using immune scores and stromal based on “Estimation STromal Immune MAlignant Tumours Expression data” algorithm represent levels cells. We found that were associated with poor prognosis ccRCC. To assess role ccRCC cells, first, performed differentially expressed genes analysis functional for validation. The results showed underlying mechanism...
The present study investigated the mechanism underlying Toll-like receptor 4 (TLR4)-mediated stimulation of hypoxia-inducible factor-1α (HIF-1α) activity and its association with reactive oxygen species (ROS) in cervical cancer cells. SiHa cells were cultured randomized to control, lipopolysaccharide (LPS), methyl-β-cyclodextrin (MβCD)+LPS, ammonium pyrrolidinedithiocarbamate (PDTC)+LPS, ST2825+LPS small interfering (si) RNA TLR4+LPS treatment groups. Cell proliferation was quantified using...
<h3>Objectives:</h3> Cisplatin (CDDP) is a widely used and effective basic chemotherapeutic drug for the treatment of variety tumors, including ovarian cancer. However, adverse side effects acquired resistance are observed in clinical application CDDP. Identifying mode administration that can alleviate reduce has become promising strategy to solve this problem. <h3>Methods:</h3> In study, 3D printing technology was prepare CDDP-poly (lactic-co-glycolic acid) (CDDP-PLGA) polymer compound...
Endometriosis is a common gynecological disease characterized by the presence and growth of endometrial tissue outside uterus, including pelvis abdominal cavity. This condition causes various clinical symptoms, such as non-menstrual pelvic pain, dysmenorrhea infertility, seriously affecting health quality life women. To date, specific mechanism key molecules endometriosis remain uncertain. The purpose present study was to elucidate mechanisms involved in development persistence disease. A...
Pelvic organ prolapses (POP) notably reduces the quality of life in elderly populations due to bladder and bowel dysfunction, incontinence, coital problems. Extracellular matrix (ECM) disorder is a pivotal event progression POP, but date, its specific underlying mechanism remains unclear. The ligaments patients with POP healthy controls were collected compare expression Homeobox11 (HOXA11) transforming growth factor β (TGF‑β1) via immunohistochemical analysis. HOXA11 TGF‑β1 overexpressed or...
Ovarian cancer (OC) has the worst prognosis among all malignancy types in females worldwide according to epidemiological studies 2017. Although radiotherapy, chemotherapy and surgical treatment are most common methods, their curative effects not satisfactory. The present study aimed examine role of cluster differentiation 44 variant 6 (CD44v6) molecular mechanism proliferation tumorigenicity OC cells, provide a novel target for clinical OC. A total 46 samples were collected, including 24...
Cervical cancer is one of the most common types gynecological tumor, and thus identifying complementary or substitute treatment methods to treat cervical important. The present study aimed evaluate effect arsenic trioxide (ATO), a traditional Chinese medicine, on cells its underlying mechanism. MTT, colony formation Transwell assays were performed investigate effects different concentrations ATO cell proliferation invasion, respectively. Western blotting reverse transcription-quantitative...
Background. Epithelial ovarian cancer (EOC) is an extremely lethal gynecological malignancy and has the potential to benefit from immune checkpoint blockade (ICB) therapy, whose efficacy highly depends on complex tumor microenvironment (TME). Method Result. We comprehensively analyze landscape of TME its prognostic value through infiltration analysis, somatic mutation survival analysis. The results showed that high cells predicts favorable clinical outcomes in EOC. Then, detailed EOC had...
Abstract The INO80 complex, a SWI/SNF family chromatin remodeler, has regulatory effects on ESC self‐renewal, somatic cell reprogramming and blastocyst development. However, the role of in regulating trophoblast cells recurrent miscarriage (RM) remains elusive. To investigate vivo Ino80 embryo development, we disrupted C57 mice, which resulted embryonic lethality. Silencing led to decreased survival capacity, migration invasion trophoblasts. Furthermore, RNA high‐throughput sequencing...
Abstract In this study, a facile, efficient, and surfactant‐free method to synthesize silica nanosphere‐supported ultrafine silver nanoparticles (AgNPs) (~2.5 nm) was developed, their antibacterial effects were investigated. the synthesis process, hydrolysis of 3‐mercaptopropyltrimethoxysilane adopted provide thiol groups in situ reduce Ag + 0 for AgNPs formation on surface nanosphere. Electron microscopy characterization complex formed revealed that not agglomerated grow without any...
You have accessJournal of UrologyKidney Cancer: Basic Research & Pathophysiology II1 Apr 2016MP85-07 URINARY MIRNAS AS A PREDICTOR OF TUMOR RECURRENCE IN PATIENTS WITH CLEAR CELL RENAL CARCINOMA Rodolfo Borges Dos Reis, Xian Shu, Yuanqing Ye, Beatriz Sanchez Espiridion, Maosheng Huang, Mehrad Adibi, Leonardo Borregales, Lisly Chery, Jose Karam, Xifeng Wu, and Christopher Wood ReisRodolfo Reis More articles by this author , ShuXian Shu YeYuanqing Ye EspiridionBeatriz Espiridion HuangMaosheng...