A5112894501- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Plant Virus Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Domain Adaptation and Few-Shot Learning
- Respiratory viral infections research
- Multimodal Machine Learning Applications
- Data Visualization and Analytics
- Herpesvirus Infections and Treatments
- Bacteriophages and microbial interactions
- 3D Shape Modeling and Analysis
- COVID-19 diagnosis using AI
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS Research and Interventions
- RNA and protein synthesis mechanisms
- Extracellular vesicles in disease
- Machine Learning in Bioinformatics
- Text and Document Classification Technologies
- Cell Image Analysis Techniques
- Urban Green Space and Health
- Image Processing and 3D Reconstruction
Yangtze University
2025
Sichuan University
2025
Huazhong University of Science and Technology
2025
Wuhan University of Technology
2022-2025
West China Medical Center of Sichuan University
2025
Shanghai First Maternity and Infant Hospital
2023-2024
Central South University
2023-2024
ShanghaiTech University
2020-2024
Guangzhou Eighth People's Hospital
2023-2024
Guangzhou Medical University
2020-2024
Green city areas are crucial in mitigating the Urban Heat Island Effect (UHI). However, cooling effect of green can be influenced by surrounding complex urban spatial environment. This study focuses on Changsha, a subtropical China, where 40 were screened and analyzed. The aims to quantify specific impact morphology areas. Through statistical correlation regression analysis, this focused six indicators: building density (BD), floor area ratio (BFR), volume (BVD), evenness index (BEI),...
Fe–polyphenols coordination polymers have emerged as a versatile theranostic nanoplatform for biological applications owing to the appealing biocompatibility of precursors from nature. Incorporating bioactive molecules with is greatly significant take full advantages their superiorities advanced application. Herein, we show functional-protein-assisted fabrication Fe–gallic acid (GA) nanonetworks via mild and facile biomineralization photothermal therapy. Mild alkaline condition crucial...
We tackle the problem of novel class discovery, which aims to learn classes without supervision based on labeled data from known classes. A key challenge lies in transferring knowledge known-class learning Previous methods mainly focus building a shared representation space for transfer and often ignore modeling relations. To address this, we introduce relation predicted distribution model trained Empirically, find that such becomes less informative during typical discovery training. prevent...
The quality of Supervised Fine-Tuning (SFT) data plays a critical role in enhancing the conversational capabilities Large Language Models (LLMs). However, as LLMs become more advanced, availability high-quality human-annotated SFT has significant bottleneck, necessitating greater reliance on synthetic training data. In this work, we introduce Condor, novel two-stage generation framework that incorporates World Knowledge Tree and Self-Reflection Refinement to produce at scale. Our...
Abstract T-Cell-derived extracellular vesicles (TcEVs) play key roles in immune regulation and tumor microenvironment modulation. However, the heterogeneity of TcEV remains poorly understood due to technical limitations EV analysis lack comprehensive data. To address this, we constructed TcEVdb, a database that explores expression cluster by SEVtras method from T-cell single-cell RNA sequencing TcEVdb contains 277 265 droplets 51 types across 221 samples 21 projects, covering 9 tissue...
The high metabolism and excessive growth of tumor cells result in the development a microenvironment (TME) enhanced lysosomal activity within cells, which can eliminate chemotherapeutics. Consequently, design nanocarriers that respond to TME target cell lysosomes represents an optimal strategy enhance drug specificity utilization efficiency. Herein, inspired by protein immobilization, dual-responsive supramolecular nanomedicine FPA/DOX is developed for specifically targeting lysosomes. Upon...
Human adenovirus type 3 (HAdV-3) is a causative agent of acute respiratory disease, which prevalent throughout the world, especially in Asia. Here, complete genome sequences two field strains HAdV-3 (strains GZ1 and GZ2) isolated from children with infection southern China are reported (GenBank accession nos DQ099432 DQ105654, respectively). The genomes were 35 273 bp (GZ1) 269 (GZ2) both had G+C content 51 mol%. They shared 99 % nucleotide identity four early five late regions that...
Narrative visualization for scientific data explorations can help users better understand the domain knowledge, because narrative visualizations often present a sequence of facts and observations linked together by unifying theme or argument. in immersive environments provide with an intuitive experience to interactively explore data, brand new strategy interactive exploration. However, it is challenging develop environments. In this paper, we propose tool create customize ordinary little...
Respiratory syncytial virus (RSV) is the leading viral pathogen associated with bronchiolitis and lower respiratory tract disease in infants young children worldwide. The epithelium primary initiator of pulmonary inflammation RSV infections, which cause significant perturbations global gene expression controlling multiple cellular processes. In this study, differential display reverse transcription polymerase chain reaction amplification was performed to examine mRNA a human alveolar cell...
Classical swine fever virus (CSFV) is capable of counteracting innate cellular antiviral responses by inhibiting type I interferon (IFN)-alpha/beta induction. A function associated with CSFV N(pro), respect to the inhibition IFN-beta production, has been clearly elucidated. In this study, we explored role E(rns) in induction exogenous double-stranded (ds) RNA. Synthetic dsRNA (poly (IC)) was used as an stimulus trigger inhibited promoter-driven luciferase activity induced poly (IC) different...
Multiple chromatin modifiers associated with H3K9me3 play important roles in the transition from embryonic stem cells to 2-cell (2C)-like cells. However, it remains elusive how is remodeled and its association totipotency. Here, we integrated transcriptome profiles conduct a detailed comparison of 2C embryos 2C-like Globally, highly preserved dynamics within gene locus not expression change during transition. Promoter-deposited plays non-repressive activation genes In contrast, transposable...
A series of (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamide derivatives was synthesized and evaluated for inhibitory activity against monoamine oxidase (MAO)-A and-B, acetylcholine esterase (AChE), butyrylcholine (BChE). Four compounds (2i, 2p, 2t, 2v) showed good both MAO-A MAO-B, two (2d 2j) selective MAO-A, with IC50 values 1.38 2.48 µM, respectively. None the AChE; however, 12 BChE. active cytotoxicity L929cells. Molecular docking revealed several important interactions between...
To obtain and investigate the genetic characteristics of four HIV-1 near full-length genome sequences (NFLGs), aiming at a description novel circulating recombinant form (CRF) in Guangdong China. Plasma samples were collected from infected MSM patients Province who had no epidemiological association with each other. The NFLGs amplified two overlapping halves phylogenetic analyses performed using Mega V11.0.1. Recombination comprehensively screened jpHMM, RIP, BootScan analyses. Finally,...