A5102995581- Multiple Myeloma Research and Treatments
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Bone health and treatments
- Prostate Cancer Treatment and Research
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Sexual function and dysfunction studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Vector-Borne Animal Diseases
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Corneal surgery and disorders
- Veterinary medicine and infectious diseases
- Radiomics and Machine Learning in Medical Imaging
- Galectins and Cancer Biology
- Corneal Surgery and Treatments
- Adenosine and Purinergic Signaling
- Cancer-related gene regulation
- Radiopharmaceutical Chemistry and Applications
- Protein Degradation and Inhibitors
Shanghai Jiao Tong University
2013-2025
XinHua Hospital
2020-2025
University of Chinese Academy of Sciences
2024
Columbia University Irving Medical Center
2020-2023
Shanghai Chest Hospital
2014-2023
First Affiliated Hospital of Kunming Medical University
2022
Kunming Medical University
2020-2022
Shanghai Ninth People's Hospital
2013-2022
China Three Gorges University
2018-2021
Hudson Institute of Medical Research
2021
Primary intrathoracic liposarcoma is an extremely rare malignancy as well a histologic subtype of sarcoma. Relatively few reports appear in the world literatures. We explored clinicopathologic features and prognostic factors this tumor study.We retrospectively analyzed clinicopathological data 23 patients with primary who were treated Shanghai chest Hospital affiliated to Jiao Tong University, from January 2003 March 2013. These classified into three groups according distinct locations,...
No AccessJournal of UrologyUrological Survey: Abstracts: Renal Tumors, Retroperitoneum, Ureter, and Urinary Diversion Reconstruction1 Aug 1999Durability Complete Responses in Patients With Metastatic Cancer Treated High-Dose Interleukin-2. Identification the Antigens Mediating Response S.A. Rosenberg, J.C. Yang, D.E. White, S.M. Steinberg RosenbergS.A. Rosenberg More articles by this author , YangJ.C. Yang WhiteD.E. White SteinbergS.M. View All Author...
Recombinant adeno-associated virus (AAV) has attracted tremendous interest as a promising vector for gene delivery. In this study we have developed an HIV-1 vaccine, using AAV expressing env, tat, and rev genes (AAV-HIV vector). A single injection of the AAV-HIV induced strong production HIV-1-specific serum IgG fecal secretory IgA antibodies well MHC class I-restricted CTL activity in BALB/c mice. The titer remained stable 10 months. When was coadministered with AAV-IL2 vector, HIV-specific...
The study was undertaken to assess whether immunotherapy regimens with bolus high-dose interleukin-2 (IL-2) alone or lymphokine-activated killer (LAK) cells are active in previously treated, relapsed patients non-Hodgkin's lymphoma.Nineteen low- intermediate-grade lymphomas were treated IL-2 (11 patients) LAK (eight patients). administered by intravenous infusion at 720,000 IU/kg every 8 hours. Eight had low-grade histologies; 11 intermediate-grade. Eighteen received second- third-generation...
Keloids are a fibroproliferative disorder of the skin resulted from abnormal healing injured or irritated and characterized by ability to spread beyond original boundary wound. Here, we tested effect gallic acid (GA), plant polyphenol with selective growth inhibitory effects in cancer, on proliferation invasion keloid fibroblasts (KFs) isolated patients undergoing surgery. GA inhibited KF proliferation, migration, parallel downregulation matrix metalloproteinase-1 -3 upregulation tissue...
Abstract Multiple myeloma bone disease is characterized by the development of osteolytic lesions. Recent work identified matrix metalloproteinase 13 as a myeloma-derived fusogen that induces osteoclast activation independent its proteolytic activity. We now identify programmed death-1 homolog, PD-1H, bona fide MMP-13 receptor on osteoclasts. Silencing PD-1H or using Pd-1h -/ - marrow cells abrogates MMP-13-enhanced fusion and bone-resorptive Further, interacts with actin cytoskeleton plays...
Abstract Background To analyse the effects of local ( ex vivo ) or systemic in administration adenovirus type 5 encoding CTLA4Ig (AdCTLA4Ig) on its influence to prolong corneal allograft survival and study underlying mechanisms. Methods A MHC class I/II mismatched rat transplant model was used. Recipients were randomly assigned receive gene‐modified corneas expressing either CTLA4Ig, CTLA4Ig/IL‐10 a single intraperitoneal (i.p.) injection (1.0 × 10 9 1.0 infectious particles) AdCTLA4Ig 1 day...
Mucopolysaccharidosis type II (MPS II) is an X-linked lysosomal storage disorder caused by pathogenic variants in the IDS gene encoding iduronate-2-sulfatase (IDS), which hydrolyzes sulfate groups dermatan and heparan sulfate. The current treatment for MPS includes enzyme replacement therapy hematopoietic stem cell transplantation (HSCT). Both therapies have shown limited penetration through blood-brain barrier. Anecdotal cases been reported with HSCT benefit to treat neurological problems...
Abstract This report describes a giant pleural lipoma that arose from the pleura of 7th anterior intercostal space and occupied approximately 75% right cavity in 49-year-old woman. The tumor was completely excised by thoracotomy. complete histopathological investigation showed lipoma, we made review literature.
ABSTRACT. Adenovirus (Ad)–mediated gene transfer of immunoregulatory molecules prevents acute allograft rejection. It is here analyzed for the first time whether this approach may prevent development chronic renal injury in rats. Renal allografts (F344→Lewis rat) were <i>ex vivo</i> transduced group I with control Ad-construct, II three different therapeutic Ad-constructs expressing vIL-10, TNFRp55-Ig, and IL-12p40, III AdIFN-γ. Group IV served as untreated controls. Control grafts (IV)...
INTRODUCTION Helicobacter (H.) hepaticus infection causes chronic active hepatitis and induces hepatocellular tumours in A/JCr mice, but evidence of this humans is scarce.This study aimed to demonstrate the correlation between H. human primary carcinoma (HCC). MeThODsThe sera 50 patients with HCC were tested for presence anti-H.pylori anti-H.hepaticus immunoglobulin G (IgG) antibodies.The liver tissues who positive serum antibody analysed hepaticus-specific 16S rRNA, cdtB, pylori cagA, vacA...
Abstract Rationale: Insulin autoimmune syndrome (IAS) is a rare endocrine disease characterized by repeated fasting hypoglycemia or episodes of late after meals, elevated serum insulin, and positivity for insulin autoantibody (IAA) receptor antibody (IRA). We summarize the clinical manifestations treatment experiences 3 patients with IAS. Patient concerns: One patient >20-year history type 2 diabetes mellitus had irregular years insulin. Another 6-year presented 6 months Graves’ showed...
CX43 plays a critical role in tumor progression. Previous studies imply that AR pathway may be involved regulation of CX43. This study was focused on determining the relationship between and The result showed expression malignant cells higher than normal cells, nonmalignant not only is level different, but localization can also changed. After androgen stimulation inhibition pathway, Thus, an important prostate cancer cells. upstream signal
Septic cardiomyopathy (SCM) is a serious complication caused by sepsis that will further exacerbate the patient's prognosis. However, immune-related genes (IRGs) and their molecular mechanism during septic are largely unknown. Therefore, our study aims to explore hub (IRHGs) miRNA-mRNA pairs with potential biological regulation in SCM means of bioinformatics analysis experimental validation.Firstly, screen differentially expressed mRNAs (DE-mRNAs) from dataset GSE79962, construct PPI network...