A5020211114- Cardiac electrophysiology and arrhythmias
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Pain Management and Treatment
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- MicroRNA in disease regulation
- Gut microbiota and health
- Inflammatory Biomarkers in Disease Prognosis
- Diet and metabolism studies
- Cardiac Imaging and Diagnostics
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Atherosclerosis and Cardiovascular Diseases
- Ultrasound and Hyperthermia Applications
- Cancer, Lipids, and Metabolism
- Platelet Disorders and Treatments
- Autophagy in Disease and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Health and Risk Factors
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Dialysis and Renal Disease Management
- Quinazolinone synthesis and applications
Kunming Medical University
2012-2025
Second People's Hospital of Yunnan Province
2025
First Affiliated Hospital of Kunming Medical University
2011-2024
First People's Hospital of Yunnan Province
2023
Second Affiliated Hospital of Kunming Medical College
2012
Abstract Background Cardiac shock wave therapy (CSWT) improves cardiac function in patients with severe coronary artery disease (CAD). We aimed to evaluate the clinical outcomes of a new CSWT treatment regimen. Methods The 55 CAD were randomly divided into 3 groups. control group ( n = 14) received only medical therapy. In A 20), was performed times within months. B 21), underwent sessions/week, and 9 sessions completed 1 month. Primary outcome measurement 6-minute walk test (6MWT). Other...
Abstract Aim We aimed to explore the regulatory relationship among long noncoding RNA H19, micorRNA‐675 (miR‐675), vitamin D (VD) receptor (VDR), and early growth response protein 1 (EGR1) in pathogenesis of diabetic nephropathy (DN) patients with diabetes mellitus (DM). Methods Expression levels miR‐675, VDR, EGR or CIHP‐1/HEK 293 cells were measured via quantitative reverse‐transcription polymerase chain reaction western blot analysis. Computational analysis luciferase assays performed...
Abstract Background This study was undertaken to explore the predictive value of advanced lung cancer inflammation index (ALI) combined with geriatric nutritional risk (GNRI) for all-cause mortality in patients heart failure (HF). Methods and results We enrolled 1123 HF admitted our cardiology department from January 2017 October 2021. Patients were divided into four groups, according median ALI GNRI. From analysis relationship between GNRI, we concluded that there a mild positive linear...
Introduction: Luteolin inhibits platelet activation and thrombus formation, but the mechanisms are unclear. This study investigated effects of luteolin on GPVI-mediated in vitro explored effect thrombosis, coagulation, production vivo. Methods: Washed human platelets were used for aggregation, membrane protein expression, ATP, Ca2+, LDH release, adhesion/spreading, clot retraction experiments. to detect collagen convulxin-induced reactive oxygen species endogenous antioxidant effects....
Background Complex interconnections are evident among gut microbiota, circulating metabolites, inflammatory cytokines, and the pathogenesis of abdominal aortic aneurysms (AAA), with causal dynamics yet to be comprehensively elucidated. The primary objective this study was elucidate potential relationships involving microbiota-mediated plasma AAA.
Alcoholic cardiomyopathy (ACM) results from chronic alcohol misuse and primarily affects the working-age population (15-64 years). The global age-standardized rates (ASRs) of ACM disease burden declined slightly 1990 to 2021, but absolute cases increased, especially in high‒medium sociodemographic index (SDI) regions such as Eastern Europe. aim this study was inform strategies combat preventable yet escalating health issue. We calculated estimated annual percentage changes (EAPCs) quantify...
Abstract Background The goal of this study was to assess the effectiveness machine learning models and create an interpretable model that adequately explained 3-year all-cause mortality in patients with chronic heart failure. Methods data paper were selected from failure who hospitalized at First Affiliated Hospital Kunming Medical University, 2017 2019 cardiac function class III-IV. dataset explored using six different models, including logistic regression, naive Bayes, random forest...
Abstract Background Acute myocardial infarction (AMI) is indeed a significant cause of mortality and morbidity in individuals with coronary heart disease. Ferroptosis, an iron-dependent cell death, characterized by the accumulation intracellular lipid peroxides, which implicated cardiomyocyte injury. This study aims to identify biomarkers that are indicative ferroptosis context AMI, examine their potential roles immune infiltration. Methods Firstly, GSE59867 dataset was used differentially...
Non-alcoholic fatty liver disease (NAFLD) is associated with increased plasma homocysteine level, which caused by down-regulation of hepatic cystathionine beta-synthase (CBS) activity. CBS catalyzes the first step in transsulfuration to cysteine, contributes ∼50% cysteine required for biosynthesis glutathione (GSH), most abundant antioxidant cells. As glucagon-like peptide-1 (GLP-1) receptor agonists (e.g. exendin-4) effectively reverse steatosis, effect exendin-4 on both and redox status...
Ischemic heart disease is a major health threat, resulting in large number of mortalities annually worldwide. Oxidative stress one the main causes cell death during ischemia‑reperfusion (IR) injury. Cyclin dependent kinase inhibitor 1A (known as p21) important protecting tissues against IR injury, however mechanism remains unknown. In present study, oxygen‑glucose deprivation and subsequent reoxygenation (OGD/R) H9c2 heart‑derived myocytes was used model to study myocardial injury vitro....
Diabetic retinopathy (DR) is the most common microvascular complication in diabetic patients, and recent studies have shown that immune regulatory mechanisms are closely associated with retinal damage DR. Therefore, this study focused on exploring cells immune-related genes (IRGs) DR gaining insight into ceRNA by which IRGs regulate progression. Four datasets from human model tissues were obtained Gene Expression Omnibus (GEO) database. R software was first used to identify differentially...
Evodia rutaecarpa has multiple pharmacological effects and is widely used in the prevention treatment of migraine, diabetes, cardiovascular disease, cancer, other chronic diseases; however, its active compound evodiamine (Evo) have not been thoroughly investigated. The purpose this study was to investigate Evo on antiplatelet activation thrombosis. We discovered that effectively inhibited collagen-induced platelet but had no effect aggregation caused by activators such as thrombin, ADP,...
Septic cardiomyopathy (SCM) is a serious complication caused by sepsis that will further exacerbate the patient's prognosis. However, immune-related genes (IRGs) and their molecular mechanism during septic are largely unknown. Therefore, our study aims to explore hub (IRHGs) miRNA-mRNA pairs with potential biological regulation in SCM means of bioinformatics analysis experimental validation.Firstly, screen differentially expressed mRNAs (DE-mRNAs) from dataset GSE79962, construct PPI network...
The aim of this study was to investigate the effect cardiac resynchronization therapy (CRT) with right ventricular (RV) sense triggered left (LV) pacing for chronic heart failure (CHF).Thirty patients who were eligible Class I indication CRT enrolled and informed consents signed. Left ejection fraction (LVEF), diastolic mitral flow velocity time integral (VTI), regurgitation VTI, aortic valve VTI measured GE Vivid 7 (GE Medical, Milwaukee, WI, USA) before after CRT. echocardiographic...
<h3>Objectives</h3> To evaluate the security and efficiency of extracorporeal cardiac shock wave therapy (CSWT) for treatment coronary artery disease. <h3>Methods</h3> A total 45 patients with disease (CAD) were included in this study (Male 36, Female 9, mean age 67 years old). randomly divide into Shock group (25 treated energy, 200 shots/spot at 0.09 mJ/mm<sup>2</sup> 9 spots, amount to times within 3 month) control (20 not energy). The testing time points before (0 month), end nine (3...
<h3>Objectives</h3> To explore the effects of Cardiac Shock Wave Therapy (CSWT) on angiogenesis Related Cytokine CAD Patients. <h3>Methods</h3> A total 87 patients with old myocardial infarction (OMI) were enrolled in this study who received treatment Department Cardiology, 1<sup>st </sup>Affiliated Hospital Kunming Medical University from October 2008 to January 2011, 68 male and 19 female, aged 43 80 years (66.80 ± 8.41 years). The divided into different group, Group 32 cases (24 male, 8...
Little is known regarding the prognostic value of serum chloride in patients with chronic heart failure (CHF) different ejection fractions. We sought to determine postdischarge outcomes associated lower between CHF types.We reviewed medical records 1221 consecutive admitted First Affiliated Hospital Kunming Medical University from January 2017 October 2021. After excluding in-hospital death, missing follow-up data, level or dialysis therapy, 791 were included. Of these patients, 343 had...